Condition

Critical Illness clinical trials and research

• 181Clinical trials
• 52NIH research projects
• 8New in 30 days
• 47Countries

Newest Critical Illness clinical trials

All recruiting trials (newest 150 of 181)

• Predicting Extubation Problems With Machine Learning

  This study tests whether computer models can predict extubation failure in adults on ventilators in the ICU.

  Recruiting Universitas Indonesia · Jakarta, DKI Jakarta and 1 other locations · NCT07918924

• Levetiracetam Dosing in Critically Ill on CRRT

  This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07918833

• Respiratory Physiotherapy in Critically Ill Pneumonia Patients

  This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.

  Recruiting Hospital H+ Queretaro · Querétaro · NCT07909616

• Immersive VR for improving upper limb function in critically ill ICU patients

  This trial tests whether fully immersive virtual reality training added to standard ICU rehabilitation can help improve upper limb strength and coordination in adults with ICU-acquired weakness.

  Recruiting National and Kapodistrian University of Athens · Athens, Attica · NCT07901855

• Cycling with immersive VR for ICU patients recovering from critical illness

  In this crossover study, critically ill adults in the ICU will try three 10-minute cycling sessions to see if an immersive VR environment motivates them more than cycling with no visuals or cycling while watching a route on a TV.

  Recruiting KU Leuven · Leuven · NCT07894146

• Factors Influencing Outcomes in ECMO and Impella Patients

  This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT07885618

• Intravenous Fish Oil for Critically Ill Patients with High Inflammation

  This study tests whether giving IV fish oil at two different doses helps reduce inflammation in critically ill adults on breathing support.

  Recruiting Phase 2 University of Malaya · Kuala Lumpur, Kuala Lumpur · NCT07883447

• Continuous vs. Intermittent Enteral Feeding in Critically Ill Adults

  This study tests whether continuous or intermittent gastric feeding leads to different amounts of remaining stomach contents in critically ill adults.

  Recruiting Viet Duc University Hospital · Hà Nội · NCT07876141

• Ventilator Hyperinflation Plus Body Positioning to Improve Gas Exchange in VAP

  This study tests whether using ventilator hyperinflation together with different body positions can improve blood oxygen and other arterial blood gas measures in adults with ventilator-associated pneumonia.

  Recruiting Al-Zaytoonah University of Jordan · Cairo · NCT07854730

• Dynamic, non-invasive monitoring of breathing effort to guide weaning from mechanical ventilation

  This observational study tests whether daily non-invasive measurements of a patient’s breathing effort can predict when it’s safe to take them off invasive ventilation.

  Recruiting Fundació d'investigació Sanitària de les Illes Balears · Palma de Mallorca, Balearic Islands · NCT07839949

• Permissive lung-protective ventilation in invasively ventilated adults

  This study tests whether lowering the breathing rate during mechanical ventilation is better than standard lung-protective ventilation for adults in the ICU who need invasive ventilation.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, NL and 1 other locations · NCT07837128

• Intra-Abdominal Pressure Changes During CRRT in Critically Ill Adults

  This study tests how intra-abdominal pressure changes in critically ill adults on continuous renal replacement therapy using a bladder pressure measurement.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Bursa · NCT07823387

• How well beta-lactam antibiotics reach tissue in critically ill children

  This study tests whether three common beta-lactam antibiotics reach sufficient tissue levels in the muscles of critically ill children.

  Recruiting University Hospital, Ghent · Ghent · NCT07822243

• Single-beat TE-e' for estimating left atrial pressure in critically ill patients

  A noninvasive test using a single-beat TE-e' echocardiography measurement is being tried to see if it can reliably indicate elevated left atrial pressure in critically ill adults.

  Recruiting Queen Mary Hospital, Hong Kong · Hong Kong · NCT07820319

• Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

  This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT07802379

• Effects of a caregiver's physical contact on ICU patients

  This study tests whether brief physical contact from a patient’s primary caregiver can influence vital signs in adults in intensive care.

  Recruiting Universidad Autonoma del Estado de Mexico · Mexico City, Mexico City · NCT07761364

• Peripheral Perfusion Index trajectory to predict 28-day mortality in sepsis patients in the ICU

  This study tests whether changes in a finger-based perfusion index over the first 24 hours in the ICU can predict 28-day death among adults with sepsis or septic shock.

  Recruiting at 2 sites Trakya University · Edirne, Merkez and 1 other locations · NCT07740304

• Structured education for families of patients with tracheostomy in the ICU

  This trial tests whether giving a structured education session to family members of ICU patients with tracheostomies can reduce their state anxiety and improve well-being and satisfaction with care.

  Recruiting Giresun University · Giresun, Giresun · NCT07737353

• How depth of anesthesia with BIS affects heart rate and blood pressure during emergency RSI

  This study tests whether keeping BIS depth at 45-55 before laryngoscopy during rapid sequence intubation in adults in the emergency department reduces risky heart rate and blood pressure spikes.

  Recruiting Akdeniz University Hospital · Antalya · NCT07722897

• Humidification methods in trauma ICU patients on mechanical ventilation

  This study tests whether active heated humidifiers or passive heat-and-moisture exchangers work better in trauma ICU patients who need long-term mechanical ventilation.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT07713238

• Digital and Plasma Biomarkers for Delirium in the ICU

  This study tests whether digital biomarkers and blood biomarkers can help detect and predict delirium in older adults in the ICU.

  Recruiting Scripps Health · La Jolla, California and 1 other locations · NCT07694206

• Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

  Researchers will look at how γδ T cells behave in severely ill patients, including those with sepsis, to see how their metabolism and function change.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Outside of the US · NCT07680816

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• Norepinephrine Dose Reduction and Critical Closing Pressure in Distributive Shock

  This study tests how lowering norepinephrine in mechanically ventilated distributive shock patients affects critical closing pressure and related hemodynamic measures.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07653659

• Ventilation During Transport of Mechanically Ventilated Patients After Non-Cardiac Surgery

  This observational study looks at how patients who stay intubated after non-cardiac surgery are ventilated during the move from the operating room to the ICU.

  Recruiting Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva · Alessandria, Italy · NCT07646249

• Understanding how patients tolerate fluid removal during kidney support in the ICU

  This observational study tests how well critically ill adults with acute kidney injury tolerate net fluid removal during continuous renal replacement therapy.

  Recruiting at 3 sites Hospital Las Higueras · Salvador and 9 other locations · NCT07643597

• Fluorescent Probe for Real-Time Kidney Function in Critically Ill Adults

  Aging and illness can make kidney tests less reliable, so this study tests a new real-time kidney function device to see if it matches standard methods in critically ill adults.

  Recruiting Phase 4 University of Kentucky · Lexington, Kentucky · NCT07643467

• Subanesthetic Ketamine for Depressive Symptoms in ICU Patients

  This study tests whether a short course of low-dose ketamine can help reduce depressive symptoms in adults who are in the ICU.

  Recruiting at 2 sites Phase 2 Hospital Italiano de Buenos Aires · Jacksonville, Florida and 1 other locations · NCT07639359

• Does a CDT level at ICU admission predict short-term outcomes in critically ill adults?

  This study tests whether high carbohydrate-deficient transferrin levels at ICU admission can predict worse short-term outcomes for adults with critical illness from emergency department admissions.

  Recruiting Medical University of Vienna · Vienna · NCT07632716

• Protein dose and recovery in critically ill patients with acute kidney injury

  In this study, researchers look at whether giving more than 1.2 g/kg/day of protein to ICU patients with AKI affects how quickly kidney recovery happens.

  Recruiting at 4 sites Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires and 5 other locations · NCT07631221

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Pulse palpation vs arterial blood pressure in circulatory shock

  This study tests how well feeling for a pulse at typical sites matches the actual arterial blood pressure in adults with circulatory shock or risk of failure.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT07609095

• Structured telerehabilitation for cardiac patients after ICU care

  A remote, four-month cardiac rehabilitation program is being tested to see if it lowers readmissions and deaths and helps physical, cognitive, and emotional recovery after ICU stays for people with post-intensive care syndrome.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan, Milano · NCT07599306

• Virtual reality to help recovery after intensive care (PICS)

  This study will try whether immersive virtual-reality brain-training helps adults recovering from ICU-related memory and thinking problems improve more than the same games on a tablet or usual care.

  Recruiting University of Minho · Porto, Porto District · NCT07585500

• PROTECT-ICU: Training ICU staff to reduce post-ICU health problems

  This trial will test whether training ICU staff to use a standard or expanded care bundle helps adults who spend at least 48 hours in the ICU have fewer physical, thinking, or emotional problems three months after hospital discharge.

  Recruiting Spanish Society of Critical Care Medicine and Coronary Units · Orihuela, Alicante and 1 other locations · NCT07542613

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Ciprofol versus propofol for sedating adult ICU patients on noninvasive respiratory support

  See if ciprofol works better than propofol for sedating adults in the ICU who are receiving noninvasive ventilation, high-flow nasal cannula, or oxygen therapy.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07536750

• Using gut blood flow measurements to predict feeding intolerance in critically ill adults

  This study will test whether bedside ultrasound measurements of gastrointestinal blood flow can help predict which critically ill adults receiving enteral nutrition will develop feeding intolerance.

  Recruiting Ruijin Hospital · Shanghai · NCT07521111

• Deciphering why some patients stay a long time in the ICU using detailed clinical profiling

  This study will try to identify clinical patterns in adults who stay in the ICU five days or longer to better understand persistent critical illness.

  Recruiting at 6 sites Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa · Lisbon, Lisbon District and 6 other locations · NCT07510776

• Sodium bicarbonate for critically ill patients with metabolic acidosis and AKI

  This trial tests whether giving sodium bicarbonate helps reduce major kidney problems 90 days later in adults with septic or critical illness and kidney injury.

  Recruiting Phase 4 Universität Münster · Münster · NCT07464431

• Predicting post-surgery ICU outcomes using IL-6 and blood-count inflammation scores

  This study will test whether IL-6 levels and routine blood-count inflammation scores at ICU admission and 24 hours can help predict complications and in-hospital death for adults after surgery.

  Recruiting Trabzon Kanuni Education and Research Hospital · Trabzon · NCT07460141

• Delphi consensus to guide mechanical insufflation-exsufflation use in the ICU

  A panel of ICU and lung specialists will use a structured survey process to agree on best practices for using mechanical insufflation-exsufflation to help airway clearance in critically ill patients.

  Recruiting at 4 sites Medipol University · Naples and 3 other locations · NCT07420946

• Lemborexant to help Sleep and Delirium in older ICU patients

  This study tests whether lemborexant, a sleep medication, helps improve sleep and reduce delirium in adults 65 and older in the ICU.

  Recruiting Phase 4 Mahidol University · Bangkok · NCT07407400

• Life-sustaining care decisions in critically ill children

  This study looks at how decisions about withholding or withdrawing life-sustaining treatments are made for critically ill children in intensive care.

  Recruiting Göteborg University · Gothenburg · NCT07401420

• How short high-oxygen exposures affect brain blood flow during mechanical ventilation

  We will test whether brief, controlled increases in ventilator oxygen change brain blood flow in adults who are intubated and on mechanical ventilation in the ICU.

  Recruiting Erasme University Hospital · Brussels · NCT07377162

• Bedside EIT-guided respiratory physiotherapy for adults on long-term ventilators

  This trial will test whether using bedside electrical impedance tomography to guide respiratory physiotherapy helps adults who have been on a ventilator for 21 days or more get more days off the ventilator within the first 28 days.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT07372794

• Behavioral health collaborative care for people recovering after ICU

  This trial will test whether a coordinated behavioral health program using a digital app, coaching, and psychiatric support helps ICU survivors reduce anxiety, depression, and PTSD symptoms.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07372586

• Listening to music to prevent delirium in older adults in the ICU

  This trial will try whether personalized or relaxing music, played twice daily for a week, can prevent delirium and increase days alive and free of delirium or coma in adults 65 and older in the ICU.

  Recruiting Hospital Britanico de Buenos Aires · Buenos Aires, Buenos Aires F.D. · NCT07369258

• Ketone drink to see if it helps ICU delirium in adults

  A ketone supplement given by mouth or feeding tube is being tested to see if it can reduce delirium duration or occurrence in adults in the ICU compared with a placebo.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07364162

• MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Help ICU Patients Maintain Muscle Strength

  This trial tests whether adding daily 60-minute thigh electrical muscle stimulation to standard ICU care is safe and easy for adults with sepsis or critical illness to see if it slows ICU-acquired muscle weakness.

  Recruiting at 3 sites Health Discovery Labs · Rochester, Minnesota and 2 other locations · NCT07362862

• Immunological and inflammation markers linked to ICU patient outcomes

  This study will try to see if certain immune and inflammation markers taken from adults admitted to intensive care can predict one-year survival and the risk of hospital-acquired infections.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07345169

• Indirect calorimetry-guided nutrition in critically ill adults

  This study tests whether using indirect calorimetry to guide how much energy ICU patients receive improves quality of life three months after ICU stay.

  Recruiting at 3 sites University Hospital, Geneva · Geneva and 2 other locations · NCT07343440

• Metabolism and muscle recovery after an ICU stay

  We will test whether blood and muscle metabolic and inflammatory markers can help predict how well adults recover muscle strength over three months after an ICU stay or major abdominal surgery.

  Recruiting University of Liege · Liège · NCT07329530

• Real-time, algorithm-driven ventilation feedback to improve lung protection in ARDS

  This study tests whether a cloud-based, real-time ventilation feedback system helps doctors deliver more lung-protective ventilation to adults with ARDS on invasive mechanical ventilation.

  Recruiting Peking Union Medical College Hospital · Qujing, Yunnan · NCT07307066

• Predicting fluid responsiveness using PLR, PPV, and LVOT VTI in ICU patients

  In critically ill adults on ventilators, researchers test whether measuring LVOT VTI during a passive leg raise can help predict who will respond to fluid therapy.

  Recruiting Izmir Katip Celebi University · Izmir · NCT07304661

• How end-tidal CO2 changes during a leg raise help predict if fluids will help ICU patients

  This study checks if small increases in exhaled CO2 during a passive leg raise can tell doctors which critically ill, mechanically ventilated patients will respond to a fluid bolus.

  Recruiting Izmir Katip Celebi University · Izmir · NCT07304648

• Remifentanil dosing and clearance in low-weight ICU patients

  This study will test how remifentanil is processed in the body and how it affects blood pressure and sedation in low-body-weight adults on mechanical ventilation in the ICU.

  Recruiting Fudan University · Shanghai · NCT07301970

• Non-invasive forearm optical monitoring to predict fluid response in critically ill patients

  This study will try to see if a non-invasive optical sensor placed on the forearm can predict which critically ill patients will have their cardiac output increase after a passive leg-raising test.

  Recruiting Corporacion Parc Tauli · Sabadell, Spain/ Barcelona · NCT07298720

• Measure total energy use in ICU patients with a doubly labeled water test.

  This will test whether the doubly labeled water method can accurately measure daily calorie needs in adults who are critically ill in the ICU.

  Recruiting Maastricht University Medical Center · Hasselt, Limburg · NCT07256340

• Self-balancing exoskeleton to support rehabilitation after thoracic surgery

  This trial will test whether a wearable self-balancing exoskeleton (Atalante X) can help adults recovering from thoracic surgery stand and walk more safely in the ICU.

  Recruiting Phase 1/2 Wandercraft · Boston, Massachusetts · NCT07220733

• Lowering sodium and chloride in diluent and maintenance IV fluids for critically ill adults

  This trial will try using salt-free glucose for medication dilutions and a low-salt maintenance fluid to see if lowering sodium and chloride helps adults who need a prolonged stay in the ICU.

  Recruiting Phase 4 University Hospital, Antwerp · Antwerp and 3 other locations · NCT07189091

• Neuromuscular electrical stimulation for patients on invasive mechanical ventilation (MOVCARE)

  We will test whether adding neuromuscular electrical stimulation to usual physical therapy helps adults on invasive mechanical ventilation regain leg muscle strength faster.

  Recruiting Hospital Moinhos de Vento · Porto Alegre, Rio Grande do Sul · NCT07188350

• Low blood creatinine as a sign of longer ventilator use and a target for creatine supplements

  This project will test whether a low serum creatinine on admission predicts a longer need for mechanical ventilation and whether giving creatine supplements to post-ICU patients with low creatinine can shorten time on the ventilator.

  Recruiting at 2 sites University Hospital Ostrava · Brno and 1 other locations · NCT07177183

• Magnesium replacement targets for people in the ICU

  This trial will test whether keeping ICU patients' magnesium levels to a higher target versus a lower target leads to better 30-day survival and fewer episodes of atrial fibrillation.

  Recruiting at 6 sites Phase 4 Scarborough General Hospital · Ajax, Ontario and 5 other locations · NCT07173855

• Continuous versus daytime intermittent tube feeding for critically ill adults

  This trial tests whether daytime intermittent tube feeding, given as four one-hour portions between 8 am and 8 pm, leads to better blood sugar control and metabolic outcomes than continuous 24-hour tube feeding in critically ill adults on or expected to need mechanical ventilation.

  Recruiting at 5 sites Gelderse Vallei Hospital · Ede, Gelderland and 4 other locations · NCT07173504

• 6-month dietitian-guided nutrition program for patients recovering from critical illness

  This project will try giving ICU patients individualized nutrition care from a clinical dietitian during their hospital stay and for six months after to see if they consume more calories and protein than with usual care.

  Recruiting University Hospital of North Norway · Tromsø · NCT07149246

• Monocyte HLA-DR monitoring to detect immune weakness in severe intra-abdominal infections at risk for fungal invasion

  This will test whether measuring monocyte HLA-DR can reveal innate immune weakness in adult ICU patients with severe intra‑abdominal infections who are at risk for invasive Candida.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT07130799

• COPM-guided goal setting for children in the PICU

  This will try using the COPM tool with therapists and caregivers to set personalized rehabilitation goals for children aged 1–18 who are admitted to the PICU.

  Recruiting Samsung Medical Center · Seoul, Gangnam-gu and 1 other locations · NCT07128446

• Using diaphragm electrical signals (sEMG) to guide timing of breathing tube removal

  This study will test whether surface electrodes that record diaphragm muscle activity can help doctors decide if adult ICU patients on a ventilator for more than 72 hours are ready to have their breathing tube removed.

  Recruiting Cardiff and Vale University Health Board · Cardiff · NCT07110129

• Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

  We will see if surface diaphragm EMG, esophageal pressure, and oxygen use measured during a spontaneous breathing trial can predict who will fail to wean from the ventilator in the ICU.

  Recruiting Leiden University Medical Center · Leiden · NCT07109570

• Montelukast for critically ill premature infants developing bronchopulmonary dysplasia: pharmacokinetics, safety, and early efficacy

  This study gives once-daily montelukast to critically ill premature infants developing bronchopulmonary dysplasia to test how the drug moves through the body, whether it is safe, and whether it helps breathing.

  Recruiting at 5 sites Phase 1/2 Duke University · Little Rock, Arkansas and 4 other locations · NCT07101640

• Timing of supplemental parenteral nutrition in critically ill adults

  This trial will test whether starting supplemental parenteral (intravenous) nutrition on day 4 versus day 8 after ICU admission reduces 28-day death in critically ill adults who cannot meet calorie needs with enteral feeding.

  Recruiting The First Hospital of Jilin University · Changchun, Jilin and 1 other locations · NCT07085455

• Muscle wasting and swallowing problems in critically ill adults

  This project will try to see if wasting of mouth and throat muscles in adults in intensive care leads to problems with swallowing.

  Recruiting Barts & The London NHS Trust · London · NCT07076524

• Endogenous energy production in critically ill patients

  This study tests when critically ill, mechanically ventilated patients start responding normally to feeding by measuring how their own glucose, fat, and protein production changes over time.

  Recruiting Karolinska University Hospital · Stockholm · NCT07059988

• Non-invasive blood pressure monitoring in ICU with the DARE device

  This study tests whether the DARE non-invasive monitor can reliably measure blood pressure and other vital signs in adults in the ICU who have invasive arterial and urinary catheters.

  Recruiting Centre Hospitalier de Saint-Denis · Saint-Denis, France · NCT07052123

• Connected and disconnected consciousness after long ICU stays

  This project will see how often adult ICU survivors who were in a coma report near-death or out-of-body experiences and what factors are linked to those episodes.

  Recruiting University of Liege · Liège, Liège · NCT07048951

• Family involvement in treatment decisions for very old ICU patients

  This study observes how families and ICU teams communicate with patients 75 and older to see how family meetings affect planning and care.

  Recruiting St George's, University of London · London · NCT07035951

• Negative-pressure versus positive-pressure breathing after LVAD implantation

  The team will try a 15-minute period of extra-thoracic negative pressure ventilation versus standard positive-pressure ventilation in people right after durable LVAD implantation to see which better supports right ventricular function and hemodynamics.

  Recruiting Karlsburg Hospital · Karlsburg · NCT07034599

• Physical therapist agreement on muscle and nerve ultrasound for ICU patients

  This project will test whether trained physical therapists can consistently use bedside ultrasound and clinical scales to detect ICU-acquired weakness in adult ICU patients.

  Recruiting University of Chile · Santiago, Metropolitan Region · NCT07032870

• Ambulance-based mobile telemedicine for children with emergencies

  This will test whether linking ambulances to remote pediatric emergency doctors by audio-video during transport improves care and outcomes for critically ill children in Karachi.

  Recruiting at 2 sites Weill Medical College of Cornell University · Karachi, Sindh and 2 other locations · NCT07027813

• Choosing Wisely recommendations for care in the intensive care unit

  This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07013175

• Monitoring intestinal blood flow after feeding to predict gut injury in critically ill patients

  We will test whether bedside Doppler measurements of superior mesenteric artery blood flow after enteral feeding can predict acute gastrointestinal injury in adult ICU patients.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07001943

• Combining chest X-rays and arterial blood gas results to predict ventilator need in critically ill adults

  This project will test whether a computer model that uses chest X-rays and arterial blood gas results can predict which critically ill adults will need mechanical ventilation.

  Recruiting Zagazig University · Zagazig, Al Sharqia · NCT07001696

• Monitoring beta-lactam antibiotics and kidney clearance in ICU patients with acute brain injury

  This project tries to see if checking kidney clearance together with blood drug levels can quickly identify ICU patients with acute brain injury who need higher doses of beta-lactam antibiotics.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06999161

• Improving sedation practices for critically ill patients on mechanical ventilation

  This study is testing a new way to manage sedation for critically ill patients on ventilators in the ICU to see if it makes them more comfortable and reduces risks from too much sedation.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT06991777

• Evaluating how well fentanyl patches work in unstable ICU patients

  This study tests how well fentanyl patches work for pain relief in critically ill ICU patients who are either unstable and need extra support or stable and don’t.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv, Israel · NCT06966869

• Comparing two ventilation modes for ICU patients

  This study is trying to see which breathing support method, SIMV or MMV, works better for stable adult ICU patients by switching them between the two and monitoring their lung function.

  Recruiting Harran University · Sanliurfa · NCT06961227

• Finding the right amount of early rehabilitation for ICU patients

  This project will collect routine ICU data from adults to see if different amounts and types of early rehabilitation lead to better physical function and quality of life.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06960642

• High-dose inhaled nitric oxide for adults with severe pneumonia on ventilators

  This study will test whether short courses of high-dose inhaled nitric oxide help adults on ventilators with severe pneumonia recover and how the treatment affects methemoglobin levels.

  Recruiting Early Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT06950294

• Using advanced monitoring to improve fluid management in septic shock patients

  This study is testing a new monitoring device to see if it can help doctors manage fluids better for patients in septic shock and help them recover faster than standard care.

  Recruiting at 2 sites Mahidol University · Bangkok Noi, Bangkok and 2 other locations · NCT06937918

• VoiceLove app to improve communication, family engagement, and delirium in critically ill adults

  This trial will test whether the VoiceLove phone app helps families communicate with intubated adults in the medical or coronary ICU and whether it improves family engagement and reduces ICU delirium.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06923462

• Comparing high-protein and standard protein nutrition for critically ill patients at risk for refeeding syndrome

  This study is testing whether giving critically ill patients more protein in their nutrition can help them recover better and avoid serious complications while in the ICU.

  Recruiting Shahid Beheshti University · Tehran · NCT06825377

• Hyperinflammation and High Ferritin in Critically Ill Patients

  This study looks at critically ill patients with signs of high inflammation to see how their condition develops over time.

  Recruiting Charles University, Czech Republic · Pilsen, Czech Republic · NCT06820905

• Using breath analysis for quick diagnosis of respiratory diseases

  This study is testing a new way to quickly diagnose respiratory diseases by analyzing the breath of patients on ventilators to see if it can help detect problems earlier.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT06775106

• Evaluating outcomes in critically ill patients after brain surgery

  This study looks at adult patients who had brain surgery to see how well different scoring systems can predict their recovery and survival in the ICU.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing · NCT06762184

• Fasting versus continuing tube feeding before procedures for critically ill patients

  This trial will test whether stopping tube feeding before a procedure or continuing it affects recovery for adults in the ICU on mechanical ventilation.

  Recruiting at 13 sites Massachusetts General Hospital · Palo Alto, California and 18 other locations · NCT06751043

• Investigating the gut microbiome's role in sepsis and brain function in critically ill patients

  This study is trying to see how changes in gut bacteria from antibiotic use affect brain function and recovery in critically ill patients with severe infections or sepsis.

  Recruiting Jena University Hospital · Jena, Thuringia · NCT06749483

• Assessing pulse pressure to estimate stroke volume in critically ill patients

  This study is testing if measuring pulse pressure can help doctors better understand and manage blood flow in critically ill patients.

  Recruiting at 3 sites Pontificia Universidad Catolica de Chile · São Paulo and 2 other locations · NCT06737614

• Using ultrasound to assess body composition in critically ill patients

  This study is testing if ultrasound can help doctors see changes in body composition, like muscle loss and fluid shifts, in critically ill patients to improve their recovery.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT06728722

• Predicting mortality risk for people 75 and older admitted to the ICU.

  This project tries to use lab biomarker data to predict which people aged 75 and older admitted from the emergency department to the ICU are most likely to die.

  Recruiting at 12 sites Consorci Sanitari de l'Alt Penedès i Garraf · Badalona, Barcelona and 13 other locations · NCT06727903

• Comparing continuous and bolus protein delivery in critically ill children

  This study is testing whether giving protein to critically ill children in larger amounts at once helps them get better nutrition and maintain their body size better than giving it continuously over time.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06721923

• Higher versus standard protein by feeding tube to boost muscle protein synthesis in ICU patients

  This will test whether giving ventilated, critically ill adults more protein through a feeding tube (about 1.3 g/kg/day) helps their muscles make more protein over four days than standard protein (about 0.8 g/kg/day).

  Recruiting Maastricht University Medical Center · Hasselt, Limburg · NCT06714240

• Effects of High-Frequency Oscillatory Ventilation in ICU Patients

  This study is testing whether a new breathing treatment called Continuous High-Frequency Oscillatory Ventilation can improve lung function and comfort for awake ICU patients with collapsed lungs.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06702813

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Evaluating follow-up care for ICU survivors and their caregivers

  This study tests whether special follow-up care can help ICU survivors and their caregivers recover better than regular care.

  Recruiting Queen's University · Kingston, Ontario · NCT06681649

• Intensive care platform to test treatments for adults

  This project will test different commonly used treatments to see which help adults who are acutely admitted to the ICU.

  Recruiting at 17 sites Phase 4 Copenhagen University Hospital, Rigshospitalet · Vienna and 39 other locations · NCT06667999

• Ultrasound assessment of airway difficulties in critically ill preeclamptic patients

  This study tests if using two or five ultrasound views can better predict airway difficulties during cesarean sections for critically ill pregnant women with preeclampsia compared to standard methods.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT06651879

• Understanding how trauma affects the gut and bone marrow

  This study looks at how stress and inflammation after a major trauma affect the gut and bone marrow to see if they contribute to ongoing anemia and recovery issues in trauma survivors.

  Recruiting at 3 sites University of Florida · Gainesville, Florida and 2 other locations · NCT06606119

• Better ICU palliative support for older adults and their families

  This trial will test whether a mobile app called ICUconnect helps older adults in the ICU and their family caregivers get the palliative care support they need compared with usual care.

  Recruiting at 4 sites Duke University · Birmingham, Alabama and 3 other locations · NCT06588556

• Calibration of esophageal balloon catheter for patients on mechanical ventilation

  This study is testing how to better calibrate a special balloon used in the esophagus to measure pressure in patients on mechanical ventilation, to see if it helps improve their care.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06584604

• Understanding nutrition practices in critically ill adults

  This study looks at how critically ill adults in intensive care are fed to see what works best and how to improve nutrition care in hospitals.

  Recruiting Australian and New Zealand Intensive Care Research Centre · Melbourne, Victoria · NCT06576895

• Assessing the safety and effectiveness of remazolam besylate for sedation in critically ill patients on ventilators after surgery

  This study is testing if a new sedative called remazolam besylate is safe and effective for helping critically ill patients on ventilators after surgery, compared to a standard sedative.

  Recruiting Phase 4 Beijing Shijitan Hospital, Capital Medical University · Beijing, Beijing Municipality · NCT06575530

• Embedding palliative care in the medical ICU

  This study is testing whether having a palliative care specialist in the ICU can help critically ill patients get better care and improve their outcomes compared to those who don’t have this support.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06574672

• Using Vasopressin to Prevent Kidney Injury in ICU Patients

  This study is testing whether vasopressin can help prevent kidney injury in critically ill patients in the ICU.

  Recruiting Phase 2 Hospital do Coracao · São Paulo, São Paulo · NCT06547892

• Using echocardiography to manage critically ill newborns

  This study is testing if using ultrasound to check the hearts of critically ill newborns can help doctors make better treatment decisions and improve their chances of recovery.

  Recruiting Sohag University · Sohag · NCT06533787

• RECOMMEND platform testing interventions for adults receiving ECMO

  This platform tests whether different treatments, such as liberal versus restrictive red blood cell transfusion strategies, help adults on ECMO survive and need less organ support and hospital resources by day 28.

  Recruiting Phase 3 Australian and New Zealand Intensive Care Research Centre · Camperdown, New South Wales and 2 other locations · NCT06526533

• Optimizing Recovery in Trauma Patients with Enhanced Nutrition

  This trial tests whether adding extra protein nutrition shakes to standard care helps older adults with trauma recover better while in the hospital and for four weeks after leaving the hospital.

  Recruiting Duke University · Durham, North Carolina · NCT06521086

• Geriatric assessment for older patients after ICU discharge

  This study tests if giving older patients a check-up after leaving the ICU can help them recover better and improve their quality of life.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06513130

• Improving nutrition in critically ill patients with gastrointestinal issues

  This study tests if combining two types of nutrition methods can help critically ill patients with gut issues get the right amount of food they need to recover.

  Recruiting Romanian Society for Enteral and Parenteral Nutrition · Bucharest · NCT06510348

• Investigating sleep and circadian rhythm in critically ill children

  This study is testing if giving critically ill children in the PICU more light during the day and limiting their food to daytime hours can help improve their sleep patterns.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT06505447

• Improving care for critically ill children in Asia

  This study is trying to improve care for critically ill children in Asian hospitals by collecting data to find out what helps or harms their recovery and using that information to create tools that predict their outcomes.

  Recruiting at 2 sites KK Women's and Children's Hospital · Singapore and 1 other locations · NCT06481644

• Improving consent processes for legal representatives in critical care clinical trials

  This study is trying to understand how legal representatives feel about the process of getting consent for clinical trials involving critically ill patients, to make it easier for them to help with patient recruitment.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau · NCT06471400

• Combining sleep promotion and cognitive training to improve brain function in older ICU survivors

  This study is testing if helping older adults who survived ICU treatment sleep better and do brain exercises can improve their thinking skills.

  Recruiting University of Washington · Seattle, Washington · NCT06411561

• Using renal resistive index to predict acute kidney injury in high-risk patients

  This study is testing if measuring kidney blood flow using ultrasound can help doctors spot acute kidney injury earlier in high-risk patients in the intensive care unit.

  Recruiting Aswan University · Aswān, Aswan Governorate · NCT06386796

• Understanding consciousness episodes in emergency patients

  This study looks at how often patients in emergency care experience strange moments of consciousness after serious medical events and how these experiences affect their memory and overall well-being.

  Recruiting University of Liege · Liège · NCT06362525

• Improving mental health for survivors of acute respiratory failure

  This study is testing a new self-management program based on therapy to see if it can help reduce anxiety in patients recovering from acute respiratory failure in the ICU.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06341972

• Using Azithromycin to treat critical asthma in children

  This study is testing if the antibiotic Azithromycin can help children aged 3-17 with severe asthma feel better by reducing inflammation while they are in the hospital.

  Recruiting Phase 2/3 Johns Hopkins All Children's Hospital · St. Petersburg, Florida · NCT06223828

• Investigating ventilation practices in critically ill children

  This study looks at how doctors are using breathing machines for critically ill children in hospitals to see if different practices can improve their recovery and survival rates.

  Recruiting University Medical Center Groningen · Groningen · NCT06220825

• 'What Is Important to Us' communication program for families of children with severe neurological impairment in the ICU

  This intervention will try a photo‑narrative communication program with parents of children (6 months–25 years) who have severe neurological impairment in the pediatric ICU and their clinicians to see if it is feasible, acceptable, and helpful.

  Recruiting Phase 2 Seattle Children's Hospital · Seattle, Washington · NCT06208332

• Evaluating a new sedation protocol for critically ill patients on mechanical ventilation

  This study is testing a new way to provide sedation for critically ill patients on breathing machines to see if it helps them recover better than the usual method.

  Recruiting Siriraj Hospital · Bangkok, Bangkok · NCT06203405

• Evaluating muscle weakness in ICU survivors through exercise testing

  This study is trying to see how problems with blood flow after being in the ICU affect the strength and exercise ability of patients who survived serious illnesses like sepsis and shock.

  Recruiting at 2 sites University of Manitoba · Winnipeg, Manitoba and 1 other locations · NCT06193980

• Exhaled breath condensate analysis in mechanically ventilated ICU patients

  This project will collect small samples of exhaled breath condensate and blood from mechanically ventilated ICU patients to see if protein and molecular patterns can signal early lung or other organ problems.

  Recruiting at 2 sites The Institute of Molecular and Translational Medicine, Czech Republic · Olomouc and 1 other locations · NCT06189924

• Improving ICU care through behavioral strategies

  This study is testing two strategies to help ICU staff use better practices for caring for critically ill adults, especially those facing health challenges, to see if it can improve patient recovery and reduce complications.

  Recruiting at 3 sites University of Nebraska · Iowa City, Iowa and 2 other locations · NCT06184945

• Using medical honey to treat wounds in intensive care patients

  This study is trying to see if using medical honey can help heal wounds better than regular care for patients in intensive care.

  Recruiting University Hospital, Angers · Angers · NCT06150326

• Enhancing communication and support for families of critically ill patients

  This study is testing a new program to see if it can help families of critically ill patients in the ICU communicate better and feel more supported during a tough time.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT06039501

• Exploring ICU patients' experiences and end-of-life wishes

  This study is trying to understand how patients in intensive care feel about their treatment and what their wishes are for end-of-life care to help improve future ICU experiences.

  Recruiting University of Manchester · Manchester · NCT06027684

• Comparing standard and low-dose continuous renal replacement therapy for acute kidney injury

  This study tests whether using a standard dose or a lower dose of a kidney treatment can help critically ill patients with acute kidney injury recover better.

  Recruiting at 2 sites Universität Münster · Münster and 1 other locations · NCT06021288

• Evaluating the needs of older adults recovering from critical illness

  This study looks at the needs of older adults who have been in the ICU to see how their challenges after going home affect their recovery and what can help them do better.

  Recruiting Yale University · New Haven, Connecticut · NCT06006000

• Reversing muscle paralysis in critically ill patients

  This study is testing whether different medications can help critically ill patients recover faster from muscle paralysis after being intubated.

  Recruiting Seoul National University Hospital · Seoul, Jongno-gu · NCT05993390

• Monitoring microvascular function in critically ill patients using near-infrared spectroscopy

  This study is trying to see if a special light technology can safely check blood flow in the tiny blood vessels of critically ill patients in the ICU to help understand their health better.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT05985525

• Early vitamin D3 supplementation for critically ill patients

  This study tests if giving vitamin D3 early to critically ill patients with low levels can improve their health while they are in the ICU.

  Recruiting National Taiwan University Hospital · Taipei · NCT05937789

• Continuing nutrition during tracheostomy surgery

  This study tests if keeping critically ill patients on nutrition right up until their tracheostomy surgery helps them eat better afterward without increasing the risk of lung problems.

  Recruiting at 6 sites State University of New York at Buffalo · Danbury, Connecticut and 5 other locations · NCT05906472

• Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients

  This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT05883137

• Optimized nutritional therapy with early physiotherapy for long-stay ICU patients

  This program tests whether better-tailored nutrition combined with early physiotherapy helps adults on ventilators who are expected to stay in the ICU seven days or more leave the hospital with stronger muscles.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT05865314

• Individualized blood pressure targets for critically ill patients in shock

  This study is testing if setting personalized blood pressure goals for critically ill patients in shock can help them survive better and avoid serious kidney problems.

  Recruiting University of Newcastle, Australia · Newcastle, New South Wales · NCT05850962

• Using magnesium to prevent new atrial fibrillation in critically ill patients

  This study is testing if giving magnesium to critically ill patients in the ICU can help prevent new cases of atrial fibrillation.

  Recruiting Phase 4 Queen's University · Hamilton, Ontario and 3 other locations · NCT05829317

• Effects of testosterone gel on physical performance in critically ill patients

  This study tests if giving testosterone gel to critically ill patients on a ventilator can help improve their muscle strength and recovery compared to a placebo.

  Recruiting at 4 sites Phase 2 University Hospital, Clermont-Ferrand · Bordeaux and 4 other locations · NCT05825092

• Characterizing patients treated at internal medicine clinics

  This study looks at patients with serious health issues treated in internal medicine clinics to see how their different conditions affect their care and to find better ways to diagnose and treat them.

  Recruiting at 2 sites IRCCS San Raffaele · Milan and 1 other locations · NCT05780099

• Comparing non-invasive blood pressure measurements to invasive methods in critical care patients

  This study is testing a new non-invasive blood pressure device to see if it gives accurate readings compared to the standard invasive method in critical care patients of all ages.

  Recruiting at 3 sites Philips Clinical & Medical Affairs Global · Jacksonville, Florida and 4 other locations · NCT05673408

• Finding early biological signs of severe illness in ICU patients

  The study will collect blood, lung, and rectal samples from adults newly admitted to the ICU to see if early biological signs can help diagnose and personalize care for sepsis, ARDS, or other critical illnesses.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05591924

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (newest 40 of 52)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Glucocorticoids and critical illness outcomes in ICU patients

  A researcher team at Columbia University will study how glucocorticoids affect short- and long-term outcomes for people who survive critical illness, including mental health and recovery aspects.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11580346

• REPAIR-ICU: Understanding aging-like changes after critical illness to help ICU survivors

  This grant studies how surviving an ICU stay triggers aging-related changes in the body and tests interventions to help people recover.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11426690

• Understanding how individual responses to treatments vary in ARDS and sepsis

  This grant aims to help clinicians predict which patients with ARDS or sepsis will benefit most from specific treatments by using advanced computer approaches.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11403905

• Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis

  Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.

  NIH research University of Florida · Gainesville, United States · NIH-11399124

• Molecular rules of capillary leak in seriously ill kids

  A study looking at why blood vessels become leaky in severely ill children and how that leads to organ failure.

  NIH research Yale University · New Haven, United States · NIH-11393099

• Heme-Driven Immune Dysregulation in Critical Illness

  Researchers are studying how free heme from red blood cell breakdown affects the immune system in people with sepsis or chronic blood disorders, with the aim of guiding better treatments.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11378744

• Remotely Monitored HIIT After COVID-19 ICU Stay

  A home-based, high-intensity interval training program guided by wearable tech to help adults recover physical function after severe COVID-19 illness.

  NIH research Duke University · Durham, United States · NIH-11377206

• Antibiotic Dosing Personalization for Critically Ill Adults

  Aims to personalize antibiotic dosing in critically ill adults using real-time drug levels and patient factors to improve outcomes.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11360688

• Understanding Energy Use to Predict Immune Problems and Long-Term Trouble After Burn Injury

  Aims to understand how energy use in the body relates to immune problems and lasting illness after severe injuries like burns.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11334968

• Addressing What Older ICU Survivors Need to Recover Their Function

  A research project at Yale aims to understand and map the unmet needs of people aged 65 and older who have left the ICU, and how those needs relate to their ability to regain daily function after a critical illness.

  NIH research Yale University · New Haven, United States · NIH-11333004

• Precision medicine in sepsis with critical illness

  A patient-facing overview of a Stanford-led effort to tailor sepsis treatment by identifying subgroups of patients who may respond to specific therapies.

  NIH research Stanford University · Stanford, United States · NIH-11331391

• Extracellular miRNAs and immune signals in serious infections and heart injury

  Aimed at understanding how tiny RNA molecules outside cells and immune signals influence sepsis and heart attack outcomes to improve care for patients.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11328652

• How stress hormones affect recovery after severe illness

  This project looks at whether glucocorticoids (stress hormones) help people survive and recover mentally after severe illnesses like sepsis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11324599

• Muscle energy problems and recovery after critical illness

  This project looks at whether problems with the cell’s energy makers in muscles help explain why many ICU survivors, especially Veterans, have long-lasting weakness.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11316972

• Bedside molecular typing for adult ARDS

  A hospital-based computer tool that uses routine vital signs and lab tests to classify adults with ARDS into two biological subtypes to help match patients with better treatments.

  NIH research Washington University · Saint Louis, United States · NIH-11266195

• Anemia after severe burns

  Researchers are looking at how inflammation from severe burns causes anemia to find ways to reduce blood transfusions for burn patients.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11262815

• Selective modulation of neutrophils in critical illness

  A research program aims to better understand how neutrophils malfunction after severe shock and how to fix it to improve outcomes for critically ill patients with lung injury or bacterial infections.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11258973

• Better care for veterans after long stays in intensive care

  This project will compare different hospital and follow-up care approaches to find what helps veterans who spend many days in the ICU and their caregivers have a better quality of life.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11188960

• Recovering muscle strength and mobility after critical illness

  This research follows adults who survived critical illnesses like ARDS to learn how their muscles and movement recover during the first year after leaving the hospital.

  NIH research University of Kentucky · Lexington, United States · NIH-11172557

• Why tiny blood vessels leak in very sick children

  This project looks at how and why the tiny blood vessels in critically ill children leak and seeks ways to stop that leaking.

  NIH research Yale University · New Haven, United States · NIH-11166541

• Understanding Chronic Critical Illness After Severe Injury or Infection

  This work aims to better understand why some patients stay very sick for a long time after severe injuries or infections like sepsis.

  NIH research University of Washington · Seattle, United States · NIH-11144925

• Understanding the needs of older adults recovering from critical illness

  This study is looking at the challenges older adults face after spending time in the ICU, focusing on what they need to recover better, like support at home and help with rehabilitation, so we can create better ways to help them heal and avoid going back to the hospital.

  NIH research Yale University · New Haven, United States · NIH-11134754

• Personalized Care for Sepsis and Critical Illness

  This work aims to find different types of sepsis in patients to help doctors choose the best treatments for each person.

  NIH research Washington University · Saint Louis, United States · NIH-11126587

• Personalized Antibiotic Dosing for Critically Ill Patients

  This research aims to find the best way to give antibiotics to very sick patients, making sure they get the right amount for their individual needs.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11124876

• Investigating how glucocorticoids affect outcomes in critically ill patients

  This study is looking at how a type of steroid hormone called glucocorticoids can help improve recovery for people who have been very sick, especially focusing on how it affects their mental health and memory after sepsis, so we can make this treatment work better for them.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11121086

• Factors influencing long-term recovery in children after severe injuries

  This study looks at how different factors influence how well children recover after going through serious injuries or illnesses, with the hope of finding ways to help them heal better and faster.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11070321

• Identifying different types of critical illness in patients with acute respiratory distress syndrome and sepsis

  This study is looking at how to better understand and treat serious conditions like acute respiratory distress syndrome and sepsis by using smart technology to sort patients based on their unique symptoms, which could help doctors provide more personalized care right in the hospital.

  NIH research Washington University · Saint Louis, United States · NIH-11050900

• Investigating how mitochondrial dysfunction affects recovery after critical illness

  This study is looking at how problems with energy production in your muscles might affect the recovery of veterans who have survived serious illnesses, and it hopes to find ways to improve their rehabilitation.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11041032

• Investigating the role of extracellular miRNAs in immune response and heart injury during critical illnesses.

  This study is looking at tiny molecules in your blood that might play a role in how your body reacts to serious health issues like sepsis and heart attacks, with the goal of finding out how they affect inflammation and heart function, so we can better understand and help patients like you.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11026358

• Understanding how inflammation causes anemia in burn patients

  This study is looking at why people with severe burns often have anemia, especially how inflammation might be making it harder for their bodies to produce red blood cells, and it aims to find new ways to help reduce the need for blood transfusions during their recovery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11010769

• Using nutrition to enhance immune function in critically ill patients

  This study is looking at how special diets can help boost the immune system and recovery for patients who are very sick, by focusing on the good bacteria in their gut.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11010333

• Improving care for Veterans with long-term critical illness

  This study is looking for ways to help Veterans who have spent a long time in the ICU feel better and improve their quality of life after they leave the hospital, while also supporting their caregivers.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-10992466

• Understanding how blood vessel control affects critically ill patients

  This study is looking at how a specific protein called Angiopoietin-2 affects blood vessel responses during sepsis, a serious infection, to help doctors predict outcomes and improve care for patients in intensive care, while also exploring genetic factors that might help tailor treatments for individuals.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10983537

• Understanding genetic risks for serious illnesses in children

  This study is looking at how genes might play a role in serious illnesses in kids, helping doctors find out which children are at higher risk and how they might respond to treatments, so they can provide better care.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10933497

• Understanding muscle recovery after serious illness

  This study is looking at how people who have survived serious illnesses like sepsis and respiratory failure can get their strength and physical abilities back, so we can find ways to help everyone recover better after they leave the hospital.

  NIH research University of Kentucky · Lexington, United States · NIH-10930804

• Using immune profiles to prevent long-term illness in critically ill patients

  This study is looking at how the immune system can help patients who have been in the ICU avoid long-term health problems after their recovery, by analyzing their blood and immune responses to find ways to improve their healing.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10920365

• Home Exercise with Smartwatch Support for COVID-19 Recovery

  This project helps people who were very sick with COVID-19 recover their strength and balance at home using a special exercise program and a smartwatch.

  NIH research Duke University · Durham, United States · NIH-10919804

• Identifying cognitive impairment in older adults after critical illness

  This study is looking at how serious illnesses can affect thinking skills in older adults after they leave the ICU, and it aims to create a helpful program to spot any memory or thinking problems early so that patients and their families can get the right support and care.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10909938

• Understanding racial differences in recovery after critical illness

  This study is looking at how differences in race might impact the recovery of people who have survived serious illnesses, with the goal of making sure everyone gets the best care possible after leaving the hospital.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10901179

• Understanding immune responses in patients with chronic critical illness after severe trauma or sepsis

  This study is looking at how the immune system works in people who have survived serious injuries or infections and are dealing with ongoing health problems, like frequent infections and muscle weakness, to find better ways to help them feel better.

  NIH research University of Washington · Seattle, United States · NIH-10892795

Related topics

Quick answers

How many Critical Illness clinical trials are recruiting right now?

181, as of November 12, 2026. 8 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 47 countries. The most sites are in United States (39 trials), China (14 trials), Canada (10 trials), Turkey (Türkiye) (10 trials), France (10 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 9, Phase 2: 7, Phase 3: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →