Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Measure total energy use in ICU patients with a doubly labeled water test.

Official title: Measuring Total Energy Expenditure in Critically Ill Patients Using the Doubly Labelled Water Method

Run by Maastricht University Medical Center · NCT07256340 · Data updated 2026-11-12

This will test whether the doubly labeled water method can accurately measure daily calorie needs in adults who are critically ill in the ICU.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorMaastricht University Medical Center
Academic / other
Locations1 site (Hasselt, Limburg)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedJuly 2026
Study endsSeptember 2026
Registry record updatedDecember 10, 2025
Trial IDNCT07256340 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age ≥18) admitted to the ICU at Jessa Hospital with an expected ICU stay of five days or more and not receiving dialysis are the intended participants.

Probably not a fit

Patients on dialysis, those expected to be in the ICU for fewer than five days, or people admitted to other hospitals are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study applies the doubly labeled water (DLW) technique to directly measure total energy expenditure (TEE) in adult intensive care patients. Enrolled patients at Jessa Hospital will receive DLW dosing and have metabolic measurements collected over several days to capture true energy use during critical illness. Measured TEE will be compared against common predictive equations and, where available, indirect calorimetry. Findings aim to determine whether DLW can improve precision in prescribing nutrition for ICU patients.

Why it matters

Potential benefit: If successful, this could enable more accurate, personalized nutrition plans in the ICU that reduce malnutrition and improve recovery.

How similar studies have gone: DLW is the gold-standard for measuring TEE in ambulatory populations and has produced accurate results in some critically ill cohorts, but it is less commonly tested and implemented in routine ICU nutrition management.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Admitted to the ICU of Jessa Hospital
* Male and female sexes
* Age: \> 18 years old
* Expected ICU stay of 5 days or more

Exclusion Criteria:

* Dialysis

Where it's running

  • Jessa Hospital Campus Virga Jesse
    Hasselt, Limburg, Belgium
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.