Comparing two ventilation modes for ICU patients
Comparative Analysis of Ventilation Distribution in Intensive Care: Mandatory Minute Ventilation Versus Synchronized Intermittent Mandatory Ventilation Using Electrical Impedance Tomography"
This study is trying to see which breathing support method, SIMV or MMV, works better for stable adult ICU patients by switching them between the two and monitoring their lung function.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Harran University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Sanliurfa) |
| Trial ID | NCT06961227 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the effectiveness of two mechanical ventilation modes, Synchronized Intermittent Mandatory Ventilation (SIMV) and Mandatory Minute Ventilation (MMV), in adult ICU patients who are hemodynamically stable. The study utilizes Electrical Impedance Tomography (EIT) to monitor lung ventilation and perfusion in real-time, allowing for a detailed comparison of the physiological impacts of each ventilation mode. Patients will switch between SIMV and MMV to assess which mode provides better respiratory support without the need for investigational interventions.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are intubated, hemodynamically stable, and require mechanical ventilation without neuromuscular blockade.
Not a fit: Patients who are pregnant, have neuromuscular diseases, unstable hemodynamics, or require high PEEP may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve mechanical ventilation strategies, leading to better respiratory outcomes for critically ill patients.
How similar studies have performed: Previous studies have shown the effectiveness of similar ventilation approaches, but this specific comparison using EIT is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years Intubated and receiving invasive mechanical ventilation Hemodynamically stable (no vasopressor support) FiO₂ ≤ 60% PEEP ≤ 8 cmH₂O Not receiving neuromuscular blocking agents Able to tolerate switching between SIMV and MMV modes Exclusion Criteria: Pregnant or breastfeeding patients Patients with neuromuscular diseases affecting respiratory drive Unstable hemodynamics or ongoing need for vasopressors Patients requiring high PEEP (\>8 cmH₂O) Patients with DNR (do not resuscitate) status Participation in another interventional study \-
Where this trial is running
Sanliurfa
- Harran University Faculty of Medicine, Department of Anesthesiology and Reanimation — Sanliurfa, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: MELAHAT YALÇIN SOLAK, Medical Doctor
- Email: melosyalcin@gmail.com
- Phone: +905326479195
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.