Early vitamin D3 supplementation for critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effects of early vitamin D3 supplementation on critically ill patients with low calcidiol levels. Conducted in Taiwan, it aims to enroll 240 patients who will receive varying doses of vitamin D to maintain serum calcidiol levels above 30 ng/mL within 30 days of ICU admission. The study measures serum calcidiol and PTH levels at multiple time points to assess the impact of supplementation on patient outcomes. The findings will help establish guidelines for vitamin D treatment in critically ill patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18-year-old critically ill patient.
* ICU admission \< 24 hours.
* Baseline 25(OH)D levels within 24 hours of ICU admission \< 20 ng/mL.
* Expected ICU length of stay ≥ 72 hours.

Exclusion Criteria:

* Hypercalcemia (ie. total serum calcium levels \> 2.6 mmol/L).
* Disorders affecting serum 25(OH)D levels, calcium metabolism, or bone metabolism (eg, parathyroid disease, rickets, or severe cirrhosis \[Child C\]).
* Having received high-dose vitamin D3 therapy (ie. \> 2,000 IU daily or a single dose of ≥ 10,000 IU) within the past four weeks.
* Active COVID-19 at ICU admission.
* Organ transplant.
* Having had tuberculosis, sarcoidosis or kidney stones within the past year.
* Having renal dialysis, continuous kidney replacement therapy (CKRT), acute kidney injury (AKI).
* Having ICU admission within the past three months.
* Non-native-speaking patients and their families
* Pregnant women.

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Yin Yi Han, doctor
• Email: noviahan@gmail.com
• Phone: 886972651405

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.