Protein dose and recovery in critically ill patients with acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses a target trial emulation approach to compare higher versus standard/lower protein intake on day five of ICU admission in adults with AKI or worsening CKD. Participants receive exclusive enteral or parenteral nutrition and are followed for kidney recovery outcomes and related health measures. The study leverages existing clinical data from three Buenos Aires hospitals to explore potential associations between protein dose and AKI duration. Although prior trials have suggested potential benefits or harms of high protein, this analysis focuses on the AKI population under real-world critical care conditions. No interventions are assigned by the researchers; exposure is defined by the protein dose recorded in medical records.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years or older admitted to the ICU.
* Patients receiving exclusive enteral or parenteral nutrition
* Acute kidney injury or exacerbated chronic kidney disease according to KDIGO criteria (increase in creatinine greater than 0.3 mg/dL in less than 48 hours or a 1.5-fold increase in baseline creatinine in 7 days)

Exclusion Criteria:

* Patients diagnosed with chronic kidney disease with a creatinine clearance of less than 30 ml/min/m2 or on dialysis at admission.
* Patients with a history of kidney transplantation
* Patients with severe liver disease (Child-Pugh score \>7 points)
* Patients with acute kidney injury undergoing renal replacement therapy at T0
* BMI\> 30

Where it's running

• Hospital Italiano de Buenos Aires
  Buenos Aires, Buenos Aires F.D., Argentina Recruiting
• Hospital Privado Universitario de Córdoba
  Córdoba, Córdoba Province, Argentina Recruiting
• Hospital Universitario Austral
  Buenos Aires, Pilar, Argentina Recruiting
• Hospital Italiano sede San Justo Agustín Rocca
  Buenos Aires, San Justo, Argentina Recruiting
• Clinica Bazterrica
  Buenos Aires, Buenos Aires, Argentina Not yet recruiting
• Hospital Alemán
  Buenos Aires, Buenos Aires F.D., Argentina Not yet recruiting

Study contacts

• Study coordinator: Ivan Alfredo Huespe, MS
• Email: ivan.huespe@hospitalitaliano.org.ar
• Phone: +54949590200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting Extubation Problems With Machine Learning

  This study tests whether computer models can predict extubation failure in adults on ventilators in the ICU.

  Recruiting Universitas Indonesia · Jakarta, DKI Jakarta and 1 other locations · NCT07918924

• Levetiracetam Dosing in Critically Ill on CRRT

  This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07918833

• Respiratory Physiotherapy in Critically Ill Pneumonia Patients

  This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.

  Recruiting Hospital H+ Queretaro · Querétaro · NCT07909616

• Immersive VR for improving upper limb function in critically ill ICU patients

  This trial tests whether fully immersive virtual reality training added to standard ICU rehabilitation can help improve upper limb strength and coordination in adults with ICU-acquired weakness.

  Recruiting National and Kapodistrian University of Athens · Athens, Attica · NCT07901855

• Cycling with immersive VR for ICU patients recovering from critical illness

  In this crossover study, critically ill adults in the ICU will try three 10-minute cycling sessions to see if an immersive VR environment motivates them more than cycling with no visuals or cycling while watching a route on a TV.

  Recruiting KU Leuven · Leuven · NCT07894146

• Factors Influencing Outcomes in ECMO and Impella Patients

  This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT07885618

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.