Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares γδ T cells from healthy individuals, non-septic critically ill patients, and septic critically ill patients. It uses flow cytometry, mitochondrial function assays, and gene-expression data to explore how these immune cells adapt metabolically and functionally during critical illness. The work builds on initial transcriptomic findings showing changes in cytotoxic genes and mitochondrial pathways, aiming to map links between metabolism and cytotoxic potential. Results may clarify how γδ T cells contribute to early antimicrobial defense in sepsis and critical illness. The study is conducted at Union Hospital in Wuhan, with no external collaborators listed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Healthy Control Group (NHC):

   * Age ≥ 18 years.
   * No acute or chronic major diseases.
   * Provide written informed consent.
2. Non-septic Critical Illness Group (CI-NS):

   * Age ≥ 18 years.
   * Admitted to the ICU and meeting the definition of critical illness.
   * Excluded from sepsis according to the Sepsis-3 criteria (infection + ΔSOFA ≥ 2 points).
   * Written informed consent provided by the participant or legally authorized representative.
3. Septic Critical Illness Group (CI-Sep):

   * Age ≥ 18 years.
   * Admitted to the ICU and meeting the Sepsis-3 criteria (infection + ΔSOFA ≥ 2 points).
   * Written informed consent provided by the participant or legally authorized representative.

Exclusion Criteria:

* Age \< 18 years.
* Known immunodeficiency, HIV infection, active hematologic malignancy, or history of hematopoietic stem cell or solid organ transplantation within the past 3 months.
* Receipt of T-cell-targeted immunosuppressive therapy (e.g., antithymocyte globulin, calcineurin inhibitors, mycophenolate mofetil, methotrexate, or high-dose corticosteroids \>1 mg/kg/day prednisone equivalent) before ICU admission or within 24 hours after ICU admission.
* Use of immune checkpoint inhibitors (e.g., anti-PD-1/PD-L1/CTLA-4 antibodies) within the past 6 weeks.
* Expected ICU stay \< 24 hours or imminent risk of death (moribund state).
* Pregnancy or breastfeeding.
* Active major bleeding.
* Inability to obtain informed consent.

Where it's running

• Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Outside of the US, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.