Optimized nutritional therapy with early physiotherapy for long-stay ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Conducted at the Geneva University Hospital adult ICU, the study compares an optimized nutritional protocol plus early in-ICU and post-ICU mobilization to standard care for patients hospitalized seven days or longer. Eligible adults are mechanically ventilated and require enteral or parenteral nutrition, while patients with preexisting neuromuscular deficits or those unable to complete follow-up are excluded. The multidisciplinary intervention focuses on individualized caloric and protein targets, close monitoring of nutrition delivery, and progressive physiotherapy starting during the ICU stay and continuing after discharge. The primary outcome is muscle function at hospital discharge, with additional measures of functional status and rehabilitation needs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Any patient admitted to the adult ICU :

* ≥18 years old
* On mechanical ventilation with an expected length of stay ≥ 7 days
* Requiring artificial nutrition (enteral and/or parenteral nutrition)

Exclusion Criteria:

Therapeutic withdrawal Pregnant or breastfeeding patients

Neurological disorders with motor deficits:

* New or pre-existing neuromuscular or nervous system disease
* Spinal cord injury Severe polytrauma of the lower limbs (amputation etc.) Non-independent ambulation (including walking aids) before ICU admission

For organizational reasons not allowing follow-up :

* Transfer to another ICU
* Patient living abroad from Switzerland
* Patient living in nursing homes preceding to ICU admission
* Incarcerated patients
* Intellectual/cognitive disabilities or language barrier, limiting ability to follow the instructions

Where it's running

• Service of Intensive Care, Geneva University Hospital,
  Geneva, Canton of Geneva, Switzerland Recruiting

Study contacts

• Principal investigator: Claudia Heidegger, MD — University Hospital, Geneva
• Study coordinator: Claudia Heidegger, MD
• Email: claudia.heidegger@hcuge.ch
• Phone: + 41 22 37 27 440

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.