Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Improving sedation practices for critically ill patients on mechanical ventilation

Official title: Feasibility Study: Precision Sedation in Intensive Care Using Neurophysiologic and Respiratory Targets.

Run by Oslo University Hospital · NCT06991777 · Data updated 2026-11-12

This study is testing a new way to manage sedation for critically ill patients on ventilators in the ICU to see if it makes them more comfortable and reduces risks from too much sedation.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorOslo University Hospital
Academic / other
Locations1 site (Oslo, Oslo)
StatusRecruiting
StartedDecember 1, 2024
Main results expectedDecember 31, 2025
Study endsMay 31, 2026
Registry record updatedMay 28, 2025
Trial IDNCT06991777 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are critically ill patients admitted to the ICU who are expected to require sedation for more than 24 hours.

Probably not a fit

Patients admitted for palliative care or those with restrictions on ventilator treatment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This initiative aims to enhance sedation practices for patients in intensive care units (ICUs) who require mechanical ventilation. By utilizing neurophysiological and respiratory targets, the study seeks to optimize sedation levels, reducing the risks associated with oversedation and improving patient comfort. The approach involves a collaborative effort among healthcare providers at Oslo University Hospital to establish a more objective and effective sedation strategy. The goal is to minimize variability in sedation practices and improve overall patient outcomes in critical care settings.

Why it matters

Potential benefit: If successful, this approach could lead to improved patient comfort and reduced complications associated with prolonged mechanical ventilation.

How similar studies have gone: While there is ongoing research in sedation practices, this specific approach utilizing neurophysiological targets is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Admitted to ICU
* Estimated need for sedation \> 24 hours

Exclusion Criteria:

* Patients admitted for palliative care
* Patients admitted with restrictions in care (no ventilator treatment)
* Contraindication for daily interruption of sedation

Where it's running

  • Oslo University Hospital
    Oslo, Oslo, Norway
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.