Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Choosing Wisely recommendations for care in the intensive care unit

Official title: WIse CHoices in the Intensive Care Unit, a Cluster Randomized Registry Based Clinical Trial

Run by Karolinska Institutet · NCT07013175 · Data updated 2026-11-12

This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment10000 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations2 sites (Stockholm and 1 other locations)
StatusRecruiting
StartedNovember 3, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2027
Registry record updatedDecember 2, 2025
Trial IDNCT07013175 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 years or older who are treated in participating Swedish intensive care units are the intended participants.

Probably not a fit

Patients under 18 years old, and people cared for outside the participating Swedish ICUs, are not eligible and would not benefit from participating.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter interventional implementation of a Choosing Wisely protocol across Swedish intensive care units led by Karolinska Institutet. Adult patients (18+) admitted to participating ICUs will be managed according to lists of tests and interventions to question, with clinicians prompted to avoid low-value testing where appropriate. The trial will track clinical outcomes (for example mortality, duration of mechanical ventilation, need for dialysis, acute kidney injury, and length of stay), as well as use of diagnostic tests and related costs. The primary emphasis is on ensuring that reductions in testing do not produce harm to critically ill patients.

Why it matters

Potential benefit: If successful, the effort could reduce unnecessary tests and interventions, lower costs, and reduce harms from iatrogenic treatments for ICU patients.

How similar studies have gone: Choosing Wisely initiatives have reduced low-value testing and costs in several healthcare settings and some ICU reports, but high-quality data on safety and patient outcomes specifically in ICU populations remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients 18 years or older, treated in Swedish ICU's

Exclusion Criteria:

* Patients under the age of 18 years

Where it's running

  • Karolinska University Hospital
    Stockholm, Sweden
    Recruiting
  • Karolinska Institutet
    Stockholm, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.