Levetiracetam Dosing in Critically Ill on CRRT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will collect blood, CRRT effluent, and urine samples from critically ill adults receiving CRRT while they are given levetiracetam. A population pharmacokinetic model will be built using the samples, and modeling plus Monte Carlo simulations will estimate dosing regimens that achieve target drug exposure. The goal is to identify dosing strategies that maintain seizure control without overdosing in this specific patient group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older.
* Patients admitted to any ICUs.
* Patients receiving CRRT for at least 24 hours.
* Hemodynamically stable patients, defined as having a SBP of at least 90 mmHg or a MAP of at least 60 mmHg, with the norepinephrine dose remaining stable or increasing by no more than 0.1 mcg/kg/min during the preceding 6 hours.
* Patients receiving intravenous or oral levetiracetam while receiving CRRT.

Exclusion Criteria:

* Pregnant patients
* Patients who are breastfeeding.
* Patients with a known hypersensitivity to levetiracetam or who develop a hypersensitivity reaction requiring discontinuation of levetiracetam during the study.
* Patients with cirrhosis classified as Child-Pugh-Turcotte class C.
* Patients receiving extracorporeal membrane oxygenation (ECMO).
* Patients who, or whose legally authorized representatives, do not provide informed consent for study participation.
* Patients with an expected survival of less than 24 hours, as assessed by the attending physician.

Where it's running

• King Chulalongkorn Memorial Hospital
  Pathum Wan, Bangkok, Thailand Recruiting

Study contacts

• Study coordinator: Supanat Khueankaew, PharmD
• Email: supanat.khnat@gmail.com
• Phone: +6622188403

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.