Does a CDT level at ICU admission predict short-term outcomes in critically ill adults?
Official title: IMPACT - Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin A Prospective Single-center Cohort Study
Run by Medical University of Vienna · NCT07632716 · Data updated 2026-11-12
This study tests whether high carbohydrate-deficient transferrin levels at ICU admission can predict worse short-term outcomes for adults with critical illness from emergency department admissions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Status | Recruiting |
| Started | July 2, 2026 |
| Main results expected | June 2028 |
| Study ends | July 2028 |
| Registry record updated | July 6, 2026 |
| Trial ID | NCT07632716 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) admitted to the ED and then transferred to the in-house ICU are eligible.
✕Probably not a fit
Patients with direct ICU admission bypassing the ED, those with hepatic cirrhosis, pregnancy, no vascular access, or transfer to other departments early may not benefit from the study insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will measure carbohydrate-deficient transferrin (CDT) levels in adults admitted to the ICU from the emergency department. Researchers will track outcomes such as mortality, duration of mechanical ventilation, delirium, ICU length of stay, need for renal replacement therapy, and ICU readmissions during hospitalization and follow-up. The goal is to see if elevated CDT, an objective marker of hazardous alcohol use, is associated with worse clinical outcomes in non-traumatic ICU patients. Data will be analyzed to identify potential associations between CDT levels at ICU admission and subsequent patient trajectories. The study is conducted at a single center, the Medical University of Vienna, and does not involve an interventional treatment.
Why it matters
Potential benefit: If CDT at ICU admission predicts worse outcomes, clinicians could use it to identify high-risk patients and tailor monitoring or support strategies accordingly.
How similar studies have gone: Previous research has linked alcohol-use markers with adverse outcomes in critical illness, but this exact CDT-at-ICU-admission approach is relatively novel and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients ≥ 18 admitted to the Department of Emergency Medicine and subsequently transferred to an in-house intensive care unit (ICU) Exclusion Criteria: * Patients transferred to other hospital departments prior to completion of intensive care * Patients admitted directly to the ICU without passing the ED * Patients admitted to intermediate care units * Patients with pre-existing or newly diagnosed hepatic cirrhosis * Patients with known or obvious pregnancy will be excluded. * Patients with no vascular access
Where it's running
-
Medical University of Vienna
Vienna, Austria Recruiting
Study contacts
- Study coordinator: Juergen Grafeneder, MD, PhD MSc
- Email: juergen.grafeneder@meduniwien.ac.at
- Phone: +43 1 4040019640
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Permissive lung-protective ventilation in invasively ventilated adults
This study tests whether lowering the breathing rate during mechanical ventilation is better than standard lung-protective ventilation for adults in the ICU who need invasive ventilation.
-
Predicting Extubation Problems With Machine Learning
This study tests whether computer models can predict extubation failure in adults on ventilators in the ICU.
-
Levetiracetam Dosing in Critically Ill on CRRT
This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.
-
Respiratory Physiotherapy in Critically Ill Pneumonia Patients
This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.
-
Immersive VR for improving upper limb function in critically ill ICU patients
This trial tests whether fully immersive virtual reality training added to standard ICU rehabilitation can help improve upper limb strength and coordination in adults with ICU-acquired weakness.
-
Cycling with immersive VR for ICU patients recovering from critical illness
In this crossover study, critically ill adults in the ICU will try three 10-minute cycling sessions to see if an immersive VR environment motivates them more than cycling with no visuals or cycling while watching a route on a TV.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.