Selective modulation of neutrophils in critical illness
Funded at Rhode Island Hospital · NIH-11258973 · Data updated 2026-11-12
A research program aims to better understand how neutrophils malfunction after severe shock and how to fix it to improve outcomes for critically ill patients with lung injury or bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 5, 2017 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $422,722 |
| NIH project number | 5R35GM124911-09 |
| Project ID | NIH-11258973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for acute lung injury or severe infections in critical care settings, where neutrophil dysfunction is suspected to play a role.
✕Less likely to help
Patients without critical illness or immune dysfunction related to hemorrhagic shock are unlikely to benefit.
What this research studies
This project looks at how hemorrhagic shock changes neutrophil behavior and contributes to acute lung injury in critically ill patients. Researchers study when neutrophils become primed, how they move through the body, and how well they fight infections, with the goal of identifying targets to restore proper immune function. The work combines biological analysis and animal models to reveal mechanisms that could guide new therapies beyond supportive care and antibiotics. The ultimate aim is to reduce organ damage and mortality in ICU patients by correcting neutrophil dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent lung injury and improve survival for critically ill patients with severe infections.
How similar studies have gone: Previous research has linked neutrophil dysfunction to worse outcomes in critical illness, and this program extends those findings toward therapeutic targets.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Lefort, Craig Thomas — Rhode Island Hospital
- Study coordinator: Lefort, Craig Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.