Investigating ventilation practices in critically ill children
Official title: PRactice of VENTilation in Critically Ill PEDiatric Patients (PRoVENT-PED) - an International Multicenter Observational Study
Run by University Medical Center Groningen · NCT06220825 · Data updated 2026-11-12
This study looks at how doctors are using breathing machines for critically ill children in hospitals to see if different practices can improve their recovery and survival rates.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | April 1, 2034 |
| Study ends | April 1, 2034 |
| Registry record updated | February 7, 2025 |
| Trial ID | NCT06220825 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are critically ill pediatric patients aged 0-18 who require ventilatory support for more than 12 hours.
✕Probably not a fit
Patients who are premature infants or do not require prolonged ventilatory support will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This international observational study aims to explore current ventilation practices in critically ill pediatric patients across various pediatric intensive care units. It will collect detailed data on ventilatory support, including duration, ICU stay, and mortality rates, over a span of 10 years. The study seeks to identify modifiable factors related to ventilation that may influence patient outcomes, addressing a significant gap in knowledge as much of the existing data is derived from adult patient experiences. Data will be gathered during specific 4-week periods each year, with flexibility for centers to opt out as needed.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies and better outcomes for critically ill pediatric patients.
How similar studies have gone: While studies on adult ventilation practices have shown success, this approach in pediatric patients is relatively novel and underexplored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Expected use of (non-)invasive respiratory support for at least 12 hrs Exclusion Criteria: * premature infants (i.e., postconceptional age corrected for gestational age \< 40 weeks)
Where it's running
-
UMC Groningen
Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Martin CJ Kneyber, MD PhD — University Medical Center Groningen
- Study coordinator: Relin Van Vliet, MSc
- Email: r.vanvliet@amsterdamumc.nl
- Phone: 0031627560257
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.