Comparing standard and low-dose continuous renal replacement therapy for acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of standard dose continuous renal replacement therapy (CRRT) versus low-dose CRRT in critically ill patients suffering from acute kidney injury (AKI). The research aims to determine if a controlled level of azotaemia can lead to improved renal recovery in these patients. By enrolling adult patients who require CRRT, the study will assess the outcomes associated with different dosing strategies of CRRT. The findings could provide insights into optimizing treatment protocols for AKI in critical care settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age ≥18 years)
* Critically ill patients with AKI + in need of CRRT
* Written informed consent

Exclusion Criteria:

* Chronic dialysis dependency
* Chronic kidney disease with estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73m²
* severe liver cirrhosis (Child-pugh C)
* severe acidosis (pH \< 7,20 at study enrolment)
* severe hyperkalaemia (\> 6mmol/l)
* Pregnancy or breastfeeding
* persons held in an institution by legal or official order
* Dependency on the investigator or center

Where it's running

• University Hospital Münster
  Münster, Germany Recruiting
• Universitätsklinikum Tübingen; Universitätsklinik für Anästhesiologie und Intensivmedizin
  Tübingen, Germany Recruiting

Study contacts

• Study coordinator: Alexander Zarbock, MD
• Email: aki@anit.uni-muenster.de
• Phone: +492518347255

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding how patients tolerate fluid removal during kidney support in the ICU

  This observational study tests how well critically ill adults with acute kidney injury tolerate net fluid removal during continuous renal replacement therapy.

  Recruiting at 3 sites Hospital Las Higueras · Salvador and 9 other locations · NCT07643597

• Sodium bicarbonate for critically ill patients with metabolic acidosis and AKI

  This trial tests whether giving sodium bicarbonate helps reduce major kidney problems 90 days later in adults with septic or critical illness and kidney injury.

  Recruiting Phase 4 Universität Münster · Münster · NCT07464431

• Choosing Wisely recommendations for care in the intensive care unit

  This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07013175

• Using renal resistive index to predict acute kidney injury in high-risk patients

  This study is testing if measuring kidney blood flow using ultrasound can help doctors spot acute kidney injury earlier in high-risk patients in the intensive care unit.

  Recruiting Aswan University · Aswān, Aswan Governorate · NCT06386796

• Understanding brain health in ICU patients with kidney injury

  This study looks at how kidney injury affects brain health in critically ill adults in the ICU to see if measuring brain oxygen levels can help predict long-term thinking and memory problems.

  Recruiting Queen's University · Kingston, Ontario · NCT04722939

• Using albumin to improve recovery in critically ill patients with acute kidney injury

  This study is testing whether giving critically ill patients with acute kidney injury a special type of albumin instead of regular saline can help them recover better and need less kidney treatment.

  Recruiting at 9 sites Phase 4 Ottawa Hospital Research Institute · Calgary, Alberta and 15 other locations · NCT04705896

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.