Understanding genetic risks for serious illnesses in children
Genetic Risk Underlying Pediatric Critical Illness
This study is looking at how genes might play a role in serious illnesses in kids, helping doctors find out which children are at higher risk and how they might respond to treatments, so they can provide better care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10933497 on NIH RePORTER |
What this research studies
This research investigates how genetic factors contribute to unexpected critical illnesses in children. By analyzing both single gene and multiple gene influences, as well as how genetics affect drug responses, the study aims to identify specific risk groups among pediatric patients. The approach includes innovative gene-network discovery methods and extensive genetic sequencing to uncover these risks. Ultimately, the findings could lead to better-targeted therapies and improved clinical management for critically ill children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are experiencing or at risk for critical illnesses, particularly those related to respiratory failure and acute kidney injury.
Not a fit: Patients outside the age range of 0-11 years or those not experiencing critical illnesses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and personalized care for critically ill children based on their genetic profiles.
How similar studies have performed: Other research has shown promise in identifying genetic risks for critical illnesses, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Motelow, Joshua Ethan — Columbia University Health Sciences
- Study coordinator: Motelow, Joshua Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.