Understanding genetic risks for serious illnesses in children
Official title: Genetic Risk Underlying Pediatric Critical Illness
Funded at Columbia University Health Sciences · NIH-10933497 · Data updated 2026-11-12
This study is looking at how genes might play a role in serious illnesses in kids, helping doctors find out which children are at higher risk and how they might respond to treatments, so they can provide better care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $254,727 |
| NIH project number | 5K08HG012374-02 |
| Project ID | NIH-10933497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are experiencing or at risk for critical illnesses, particularly those related to respiratory failure and acute kidney injury.
✕Less likely to help
Patients outside the age range of 0-11 years or those not experiencing critical illnesses may not benefit from this research.
What this research studies
This research investigates how genetic factors contribute to unexpected critical illnesses in children. By analyzing both single gene and multiple gene influences, as well as how genetics affect drug responses, the study aims to identify specific risk groups among pediatric patients. The approach includes innovative gene-network discovery methods and extensive genetic sequencing to uncover these risks. Ultimately, the findings could lead to better-targeted therapies and improved clinical management for critically ill children.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and personalized care for critically ill children based on their genetic profiles.
How similar studies have gone: Other research has shown promise in identifying genetic risks for critical illnesses, suggesting that this approach could yield significant insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Motelow, Joshua Ethan — Columbia University Health Sciences
- Study coordinator: Motelow, Joshua Ethan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.