Using breath analysis for quick diagnosis of respiratory diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to validate a novel technique using mass spectrometry to analyze exhaled breath from non-COVID ICU patients on ventilation. The study will employ Orbitrap and MALDI mass spectrometry to capture and analyze proteins in breath samples, correlating these findings with existing clinical data to enhance early detection of pulmonary diseases. By focusing on ventilator-dependent patients, the study seeks to establish a rapid diagnostic tool that could be utilized in non-ICU settings for respiratory pathogen detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non-COVID-19 adult consented patients (\>18yo) on ventilatory support in the ICU at OHSU

Exclusion Criteria:

* Patients with "severe respiratory distress" as defined by arterial pO2 of \<60 mmHg on maximal FiO2 \& optimal ventilator settings
* Patient with severe hemodynamic instability as defined by (a) receiving IV infusion of 2 or more pressors or inotropic medications (Levophed, vasopressin, phenylephrine, or epinephrine) \& (b) MAP of \<60 mmHg or SB \<80 mmHg

Where it's running

• Oregon Health and Science University
  Portland, Oregon, United States Recruiting

Study contacts

• Study coordinator: Laura H Nguyen, B.S.
• Email: nguyelau@ohsu.edu
• Phone: 503-418-4733

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.