Low blood creatinine as a sign of longer ventilator use and a target for creatine supplements
Official title: Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
Run by University Hospital Ostrava · NCT07177183 · Data updated 2026-11-12
This project will test whether a low serum creatinine on admission predicts a longer need for mechanical ventilation and whether giving creatine supplements to post-ICU patients with low creatinine can shorten time on the ventilator.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 492 (estimated) |
| Sponsor | University Hospital Ostrava Academic / other |
| Locations | 2 sites (Brno and 1 other locations) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | February 2, 2028 |
| Registry record updated | February 5, 2026 |
| Trial ID | NCT07177183 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients admitted to post-ICU care units at the participating Chronicare locations who have subnormal serum creatinine on admission and do not have chronic liver or kidney disease are the ideal candidates.
✕Probably not a fit
Patients with advanced malignancy, a survival prognosis under three months, chronic kidney or liver disease, supranormal creatinine, those unlikely to be weaned, or patients in palliative care are unlikely to benefit from the interventions tested.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will measure serum creatinine at admission to post-ICU care units and identify patients with subnormal values. Patients with low creatinine will be allocated to receive oral creatine supplementation, a placebo, or no intervention and followed for duration of ventilatory support and weaning outcomes. Key exclusions include chronic kidney or liver disease, supranormal creatinine, patients unlikely to be weaned, or those in palliative care. The primary focus is on whether admission creatinine predicts prolonged mechanical ventilation and whether creatine intake shortens ventilation time and improves weaning success.
Why it matters
Potential benefit: If successful, the approach could help identify patients at risk of prolonged ventilation and shorten ventilator time using a low-cost supplement.
How similar studies have gone: Prior work links serum creatinine to muscle mass and there is limited evidence on creatine supplementation in critical illness, so the predictive idea has supportive rationale but the supplementation approach is relatively novel in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \<18 years of age * Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months Exclusion Criteria: * Patients who are unlikely to be weaned from ventilatory support. * Patients in palliative care or with a survival probability of \<3 months * Patients with advanced malignancy * Patients with a history of chronic kidney disease * Patients with a history of chronic liver disease * Patients with supranormal serum creatinine on admission to the post-ICU care unit * Patients who refused to sign the Informed Consent with participation in the study.
Where it's running
-
Chronicare Mund s.r.o.
Brno, Czechia Recruiting -
Chronicare s.r.o.
Milovice, Czechia Recruiting
Study contacts
- Study coordinator: Jiří Hynčica
- Email: jiri.hyncica@fno.cz
- Phone: 0042059737
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.