Condition

Respiratory Failure clinical trials and research

• 56Clinical trials
• 60NIH research projects
• 2New in 30 days
• 26Countries

Newest Respiratory Failure clinical trials

All recruiting trials (56)

• HFNC During Bronchoscopy for Respiratory Failure

  This study tests whether using high-flow nasal oxygen during fiber-optic bronchoscopy is safe and helpful for patients with respiratory failure.

  Recruiting Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07880964

• Respiratory progression in adults with Duchenne muscular dystrophy: a long-term observational study

  This study tests how respiratory function changes over three years in adults with genetically confirmed Duchenne muscular dystrophy.

  Recruiting at 13 sites Istituto Giannina Gaslini · Bologna and 12 other locations · NCT07879989

• Epidural spinal cord stimulation to help breathing after cervical spinal cord injury

  This trial tests whether adding epidural spinal cord stimulation to standard care can improve breathing in adults with cervical spinal cord injury and respiratory failure.

  Recruiting at 2 sites Zhongda Hospital · Nanjing, Jiangsu and 1 other locations · NCT07722130

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Ciprofol versus propofol for sedating adult ICU patients on noninvasive respiratory support

  See if ciprofol works better than propofol for sedating adults in the ICU who are receiving noninvasive ventilation, high-flow nasal cannula, or oxygen therapy.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07536750

• Using EEG to monitor sleep quality in ICU patients with respiratory failure

  We will test whether continuous EEG monitoring can better track sleep quality than nurse observations in conscious adults hospitalized in the ICU for acute respiratory failure.

  Recruiting University Hospital, Rouen · Rouen · NCT07522450

• High-flow nasal oxygen combined with noninvasive ventilation for acute respiratory failure

  This test will try alternating high-flow nasal oxygen and noninvasive ventilation to see if it helps adults with acute respiratory failure breathe better than noninvasive ventilation alone.

  Recruiting Minia University · Minya, Minya Governorate · NCT07521254

• Heart Rate Variability as a Marker to Guide High-Flow Nasal Cannula Therapy

  We’re testing whether heart rate variability can help decide the right flow rate for high-flow nasal cannula in adults with respiratory failure.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07518862

• PEEP levels and breathing effort during assisted mechanical ventilation

  This trial tests whether changing PEEP levels can reduce excessive breathing effort in adults receiving assisted mechanical ventilation in the ICU.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07437846

• Supraglottic airway to support breathing in premature infants born at 29–33 weeks

  We will try using a supraglottic airway to give positive-pressure breaths right after birth to premature infants born at 29 0/7–33 6/7 weeks who need help breathing.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07419438

• Bedside EIT-guided respiratory physiotherapy for adults on long-term ventilators

  This trial will test whether using bedside electrical impedance tomography to guide respiratory physiotherapy helps adults who have been on a ventilator for 21 days or more get more days off the ventilator within the first 28 days.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT07372794

• Personalized PEEP using esophageal pressure for adults with obesity on a ventilator

  This test checks whether using esophageal pressure to set PEEP helps adults with obesity who are on a mechanical ventilator.

  Recruiting at 2 sites Phase 2 University of Alberta · Edmonton, Alberta and 1 other locations · NCT07359261

• Platelet population changes during ECMO circulatory support

  This will test whether the proportions of different platelet types change during ECMO in adults with cardiac or respiratory failure.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07334457

• Real-time, algorithm-driven ventilation feedback to improve lung protection in ARDS

  This study tests whether a cloud-based, real-time ventilation feedback system helps doctors deliver more lung-protective ventilation to adults with ARDS on invasive mechanical ventilation.

  Recruiting Peking Union Medical College Hospital · Qujing, Yunnan · NCT07307066

• AI to improve telephone triage for emergency calls at CCUE Andalucía

  This project tests AI tools to help emergency call operators spot life-threatening problems like cardiac arrest, stroke, severe breathing trouble, and chest pain.

  Recruiting Centro de Emergencias Sanitarias 061 Andalucía · Málaga, Málaga · NCT07247669

• Impact of Low vs High PEEP on Diaphragm and Lung Function in Mechanically Ventilated Patients

  This study tests whether different levels of PEEP (low, medium, high) change diaphragm effort and ventilation effectiveness in adults on pressure-support ventilation in the ICU.

  Recruiting Vastra Gotaland Region · Gothenburg, Västra Götaland County and 1 other locations · NCT07188038

• Low-flow ECCO2R for ICU patients with respiratory failure: safety and outcomes

  This review looks back at adults in the ICU who received low-flow ECCO2R to see if the treatment was safe and helped people with respiratory failure, including ARDS and severe asthma.

  Recruiting Hong Kong University · Hong Kong · NCT07161271

• Community- or home-based exercise for adults with weakened heart or lungs

  This test will see if an eight-week, community- or home-based exercise program can improve heart and lung function in adults 18–85 with reduced cardiopulmonary fitness.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT07154355

• Beacons for ICU: extra clinician alerts in ICU sub-units

  This study tests whether adding the ICU Beacon clinician awareness system to standard ICU care improves outcomes for adults with respiratory or circulatory failure compared with standard care alone.

  Recruiting ETH Zurich · Bern · NCT07119411

• Pressure-support versus T-piece breathing test for overweight and obese adults on ventilators

  This test will see if a one-hour pressure-support or T-piece breathing trial helps overweight and obese adults on a ventilator be successfully extubated without needing reintubation within 72 hours.

  Recruiting Taipei Medical University Hospital · Taipei · NCT07114289

• Readiness for EXtubation (REXs) score for patients on invasive mechanical ventilation

  This will test the Readiness for EXtubation (REXs) score to see if it can predict which ICU patients on invasive mechanical ventilation can be safely extubated.

  Recruiting at 7 sites Medipol University · Punta Arenas and 6 other locations · NCT07098611

• Monitoring lung changes from prone positioning in ARDS with 3D electrical impedance tomography

  This will see if turning adults on ventilators with ARDS onto their stomachs changes lung air distribution and blood flow as measured by 3D electrical impedance tomography, and it will compare 3D to 2D EIT for monitoring.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07083973

• Combining chest X-rays and arterial blood gas results to predict ventilator need in critically ill adults

  This project will test whether a computer model that uses chest X-rays and arterial blood gas results can predict which critically ill adults will need mechanical ventilation.

  Recruiting Zagazig University · Zagazig, Al Sharqia · NCT07001696

• Using a diaphragm ultrasound index (DPSI) to set high-flow nasal oxygen flow

  This will test whether a diaphragm ultrasound score (DPSI) can help doctors set the best high-flow nasal cannula (HFNC) flow for adults with acute respiratory failure.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang and 1 other locations · NCT06996665

• High-flow oxygen therapy for patients weaning off mechanical ventilation

  This study tests if high-flow oxygen therapy can help patients with tracheostomies breathe easier and clear mucus better while they are transitioning off mechanical ventilation.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06776939

• Investigating Biomarkers in Acute Respiratory Distress Syndrome

  This study is trying to see if certain markers in the blood can help us understand how Acute Respiratory Distress Syndrome affects the lungs and how severe the condition is in patients.

  Recruiting University of Padova · Padova, PD · NCT06774534

• Evaluating ultrasound-guided pleural drainage in ICU patients with respiratory failure

  This study is testing if using ultrasound to help drain fluid from the lungs can improve the health of adults in the ICU who are struggling to breathe.

  Recruiting at 4 sites Aalborg University Hospital · Aalborg and 5 other locations · NCT06709456

• High-flow nasal cannula versus noninvasive ventilation after extubation in people with systolic heart failure

  This pilot will test whether high-flow nasal cannula or noninvasive ventilation after extubation better prevents reintubation in adults with systolic heart failure who were on a ventilator.

  Recruiting Yale University · New Haven, Connecticut · NCT06671015

• How different oxygen targets and interfaces affect oxygen flow in patients needing supplemental oxygen

  This study tests how the oxygen delivery interface (nasal cannula at various flow rates, open mask, or simple mask) and SpO2 target settings influence the amount of oxygen flow patients require.

  Recruiting Laval University · Québec, Quebec · NCT06646991

• Routine versus on-demand ECMO during lung transplant

  This trial tests whether using ECMO routinely during lung transplant or only when needed leads to fewer complications for people having a lung transplant.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Edmonton, Alberta and 3 other locations · NCT06615492

• Personalized diaphragm pacing to improve outcomes in ventilated patients

  This study is testing if a personalized diaphragm pacing treatment can help critically ill patients on ventilators recover better and get off the machines more easily.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06609577

• Music therapy during pediatric extubation.

  See if adding music therapy during extubation helps stabilize vital signs and heart rate variability in children coming off mechanical ventilation.

  Recruiting at 2 sites Sanitas University · Bogotá, Bogota D.C. and 1 other locations · NCT06591533

• Effect of phosphocreatine on patients treated by medical emergency teams

  This study tests if giving phosphocreatine to hospitalized patients with serious conditions can help them recover faster and shorten their hospital stays compared to those who receive a placebo.

  Recruiting Phase 3 Università Vita-Salute San Raffaele · Milan · NCT06503016

• Evaluating the effects of light and magnetic therapy in patients on mechanical ventilation

  This study is testing whether a combination of light and magnetic therapy can help adults on mechanical ventilation recover faster and improve their breathing muscle strength compared to a placebo treatment.

  Recruiting University of Nove de Julho · Porto Alegre, Rio Grande do Sul · NCT06454006

• Effect of Traditional Chinese Medicine on Organ Failure in Critically Ill Patients

  This study is testing whether traditional Chinese medicine can help critically ill patients with organ failure in the ICU feel better and recover faster.

  Recruiting China Medical University Hospital · Taichung · NCT06452966

• Comparing two suction methods for intubated infants

  This study is testing whether a new suction device is better for preterm and term infants on breathing machines than the standard suction method by looking at how it affects their heart rate and oxygen levels.

  Recruiting Columbia University · New York, New York · NCT06443970

• Caffeine citrate loading dose before extubation in preterm infants

  This study tests if giving a dose of caffeine to preterm babies before they are taken off the ventilator can help them breathe better and stay off the machine successfully.

  Recruiting at 2 sites Phase 4 Semmelweis University · Budapest and 1 other locations · NCT06401083

• Using a closed-loop oxygen controller for high flow oxygen treatment in critically ill adults

  This study is testing a new system that automatically adjusts oxygen levels for critically ill adults with breathing problems to see if it helps them breathe better than the usual method.

  Recruiting at 2 sites Başakşehir Çam & Sakura City Hospital · Istanbul and 1 other locations · NCT06374589

• Improving mental health for survivors of acute respiratory failure

  This study is testing a new self-management program based on therapy to see if it can help reduce anxiety in patients recovering from acute respiratory failure in the ICU.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06341972

• High-flow oxygen treatment after spinal cord injury

  This study will test whether giving high-flow oxygen for 10 days helps people with recent neck or upper-back (C4–T4) spinal cord injuries avoid breathing complications.

  Recruiting Cardiff and Vale University Health Board · Cardiff · NCT06244160

• Investigating ventilation practices in critically ill children

  This study looks at how doctors are using breathing machines for critically ill children in hospitals to see if different practices can improve their recovery and survival rates.

  Recruiting University Medical Center Groningen · Groningen · NCT06220825

• Evaluating a new sedation protocol for critically ill patients on mechanical ventilation

  This study is testing a new way to provide sedation for critically ill patients on breathing machines to see if it helps them recover better than the usual method.

  Recruiting Siriraj Hospital · Bangkok, Bangkok · NCT06203405

• Comparing different oximeters for measuring oxygen levels in ICU patients

  This study is testing how accurately different oximeters measure oxygen levels in ICU patients to see which ones give the best readings.

  Recruiting at 2 sites Laval University · Montreal, Quebec and 4 other locations · NCT06102499

• Comparing precision ventilation to standard care for ARDS

  This study tests if a personalized breathing method can help people with Acute Respiratory Distress Syndrome survive better than the usual care they receive.

  Recruiting at 30 sites Phase 3 Beth Israel Deaconess Medical Center · Tucson, Arizona and 32 other locations · NCT06066502

• Enhancing communication and support for families of critically ill patients

  This study is testing a new program to see if it can help families of critically ill patients in the ICU communicate better and feel more supported during a tough time.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT06039501

• Using awake prone positioning to improve respiratory failure treatment

  This study is testing if having patients with breathing problems lie on their stomach while awake can help them breathe better and reduce the need for a breathing tube.

  Recruiting Vilnius University · Kaunas and 3 other locations · NCT05990101

• Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients

  This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT05883137

• Pain management approach for trauma patients on mechanical ventilation

  This study tests whether a new pain management approach for trauma patients on breathing machines can help them feel more comfortable and reduce the time they need on the ventilator compared to the usual method.

  Recruiting MemorialCare Health System · Long Beach, California · NCT05751863

• Comparing oxygen targets with different oximeters for better oxygen flow management

  This study tests whether using different types of oximeters can help manage oxygen flow better for patients recovering from heart surgery.

  Recruiting Laval University · Québec, Quebec · NCT05590130

• How diaphragm strength changes during and after mechanical ventilation

  This project will try to see how quickly the diaphragm weakens in ICU patients on mechanical ventilation and whether it recovers after they are taken off the ventilator.

  Recruiting RWTH Aachen University · Aachen · NCT05211661

• Comparing helmet ventilation, CPAP, and high-flow oxygen for respiratory failure

  This study is testing whether helmet ventilation, CPAP, or high-flow oxygen can help people with serious breathing problems avoid needing a breathing tube.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT05089695

• Using noradrenaline to prevent cardiovascular collapse during tracheal intubation

  This study is testing if giving critically ill adults noradrenaline before tracheal intubation can help prevent serious drops in blood pressure and heart problems during the procedure.

  Recruiting at 3 sites Phase 3 University of Turin, Italy · Nantes and 5 other locations · NCT05014581

• Understanding quality of life in patients with chronic respiratory failure

  This study looks at how different treatments for chronic respiratory failure, like non-invasive ventilation, affect the daily lives and well-being of patients.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT04236726

• Evaluating the safety and performance of the MOBYBOX System for heart and lung support

  This study is testing how safe and effective the MOBYBOX system is for helping patients with heart and lung failure.

  Recruiting at 4 sites Hemovent GmbH · Hanover, Lower Saxony and 3 other locations · NCT04183660

• Observing recovery from weakness after severe respiratory and cardiac failure

  This study looks at how people who had severe breathing and heart problems recover from weakness after being in intensive care and on a special life-support machine, to see what helps or hinders their recovery.

  Recruiting Barts & The London NHS Trust · London · NCT03753412

• Understanding diaphragm changes in patients awaiting lung transplants

  This study looks at how different breathing support methods affect the diaphragm in patients waiting for lung transplants to find ways to reduce diaphragm damage.

  Recruiting University Health Network, Toronto · Toronto · NCT03667027

NIH-funded research (newest 40 of 60)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using a simple breathing test to check lung function after kids’ acute respiratory failure

  A study will test a child-friendly breathing method (oscillometry) to check how well lungs work after severe respiratory illness in kids.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11530755

• Financial hardship in acute respiratory failure patients and their family caregivers

  This grant studies how money worries affect patients with acute respiratory failure and their family caregivers, aiming to improve outcomes for both sides.

  NIH research University of Washington · Seattle, United States · NIH-11411238

• Imaging how belly fat affects lung collapse in severe breathing failure

  A hospital-based study will use CT scans and AI tools to understand how truncal fat distribution changes lung collapse and treatment response in patients with acute hypoxemic respiratory failure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11408601

• Understanding how to apply sepsis care guidelines in ICU patients with respiratory failure

  A patient-friendly look at how hospitals can best use sepsis care bundles to save lives for people with breathing problems in the ICU.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11393914

• Kindergarten readiness after early brain injury and ICU sedation

  This study follows preschool-age children who had critical illness as babies or toddlers to see how early ICU sedation may relate to later school-readiness using kindergarten readiness scores.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11373835

• Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis

  A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11372276

• Combination therapy with a helmet-style negative pressure system for acute breathing failure

  A new approach tests using high-flow oxygen together with a modern negative pressure device to help adults with acute hypoxemic breathing failure avoid invasive ventilation.

  NIH research New York University School of Medicine · New York, United States · NIH-11351229

• Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure

  Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11348199

• Using a simple breathing test to check how kids recover lung function after severe lung illness

  A study will test a quick, noninvasive breathing test called oscillometry to see how well children who survived dangerous lung problems recover over time.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11324603

• Breathing effort and ventilator safety in severe respiratory failure

  This research looks at how a person's own breathing effort affects lung and diaphragm injury for adults on ventilators for acute respiratory failure.

  NIH research New York University School of Medicine · New York, United States · NIH-11258593

• A mass-producible biomimetic artificial lung to help people with severe respiratory failure

  A new, easier-to-manufacture microfluidic oxygenator is being developed to support adults with severe respiratory failure such as ARDS as an alternative to standard ECMO devices.

  NIH research Biomembretics, INC. · Scituate, United States · NIH-11239378

• Helping survivors of acute respiratory failure manage anxiety

  This study is looking to help adults who have recovered from serious breathing problems feel less anxious by trying out a new self-help program, and it will start by talking to patients in the hospital to make sure the program meets their needs before testing it against regular care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11201357

• Financial strain for adults with acute respiratory failure and their family caregivers

  This project looks at how medical bills, lost income, and money worries affect adults with acute respiratory failure and the family members who care for them.

  NIH research University of Washington · Seattle, United States · NIH-11171365

• Recovery expectations after acute breathing failure for survivors and their caregivers

  This project looks at how adults who survive sudden respiratory failure and their family or unpaid caregivers think about recovery and how those expectations affect coping and mental health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11167560

• Why low-oxygen episodes in very premature babies can cause memory problems

  This work explores whether a brief low-oxygen event around birth changes how hippocampus cells mature and leads to lasting learning and memory problems in babies born very early.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11166447

• Understanding how care decisions affect outcomes for patients with breathing problems and sepsis

  This project looks at hospital records to understand how decisions about where patients with severe breathing issues and sepsis receive care affect their recovery.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11160556

• Azithromycin for RSV-induced Respiratory Failure in Children

  This project looks at whether azithromycin can help children with severe breathing problems caused by RSV.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11145744

• Understanding Fragmented Care for Acute Respiratory Failure

  This project looks at how different doctors caring for patients with acute respiratory failure might affect their recovery and what hospitals can do to help.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11136885

• Improving sepsis care for patients with breathing failure

  This project tries new ways to help hospitals deliver sepsis treatments faster for people with sepsis or acute respiratory failure.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11136405

• Evaluating lung function in children after severe respiratory illness

  This study is looking at how to check lung health in young kids under 6 who have recovered from serious breathing problems, like those caused by pneumonia or asthma, using a gentle method that doesn't require them to do any tricky breathing exercises, so we can better understand how these issues affect their lungs in t

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11117616

• Understanding the risks of acute respiratory failure in patients with hospital-onset sepsis

  This study looks at how patients with hospital-onset sepsis might face different chances of developing breathing problems, and it aims to find better ways to treat those at higher risk so they can get the care they need to feel better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11082526

• Respiratory drive and ventilator care in acute respiratory failure

  A study at NYU School of Medicine will explore how a patient’s own breathing effort affects lung injury during invasive ventilation in adults with acute respiratory failure.

  NIH research New York University School of Medicine · New York, United States · NIH-11082204

• Understanding aspiration risks in survivors of acute respiratory failure

  This study is looking at how to spot patients who might have trouble swallowing safely after they’ve been on a breathing machine, so we can help prevent serious problems like pneumonia and make their recovery easier.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11080989

• Improving care for patients with acute respiratory failure at the end of life

  This study is looking at ways to improve care for patients with severe breathing problems, especially those who are close to the end of their lives, by trying out short-term treatment plans that help everyone involved—patients, families, and doctors—make better decisions together about what care is best for them.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11077805

• Improving ICU care for people with respiratory failure

  This project aims to change ICU practices to help Hispanic patients with respiratory failure survive and recover better.

  NIH research New York University · New York, United States · NIH-11073082

• A model to predict respiratory failure in COVID-19 patients

  This study is creating a smart tool that uses health data to help doctors predict if COVID-19 patients might need breathing support within the next day, so they can act quickly and improve care.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11046630

• Examining opioid use in patients with acute respiratory failure on ventilators

  This study looks at how doctors prescribe pain medications called opioids to patients who are on breathing machines due to serious lung problems, and it aims to understand how these medications affect their recovery and overall health in the long run, so we can improve pain management for people in critical care.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11027460

• Understanding why critically ill patients with respiratory failure and sepsis face health disparities.

  This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11018640

• Improving early respiratory care for ALS patients at risk of respiratory failure

  This study is looking to improve breathing care for people with ALS who might face serious breathing problems, by finding out who could benefit from early help and listening to their thoughts on treatments, so we can better support their needs.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11012778

• Helping survivors of acute respiratory failure manage anxiety

  This study is looking to help adults who have recovered from serious breathing problems and are dealing with anxiety by testing a new program that teaches them how to manage their feelings better, so they can feel less anxious and improve their overall well-being.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11012252

• Understanding uncertainty and expectations in survivors of acute respiratory failure

  This study is looking at how people who have survived serious breathing problems feel about their health and recovery, and how this uncertainty affects their daily lives, so we can find better ways to support them after their hospital stay.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10998341

• Improving decision-making for patients with severe breathing problems

  This study is all about helping doctors and patients with acute respiratory failure make better choices about treatment that match what patients really want, especially when it comes to end-of-life care, by improving communication and understanding between families and healthcare providers.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10984300

• Improving outcomes for survivors of acute respiratory failure through family-centered care

  This study is looking at a new way to help people recover better after they’ve had serious breathing problems by involving their families in the care process, and it’s designed for patients and their loved ones to work together for better health outcomes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10984281

• Understanding how lung immune cells affect COVID-19 lung damage

  This study is looking at how certain immune cells might be hurting the lungs of people with severe COVID-19, and it's for anyone interested in understanding more about the virus and finding better ways to help patients breathe easier.

  NIH research Cornell University · Ithaca, United States · NIH-10979157

• Understanding how low oxygen affects memory in preterm infants

  This study looks at how low oxygen levels can affect memory and brain development in preterm babies who have had serious breathing problems, using a mouse model to help understand the long-term impacts on learning and memory.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10939062

• Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis

  This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10918227

• Using Ganciclovir to Prevent Cytomegalovirus Reactivation in Patients with Severe Respiratory Issues

  This study is looking at whether the antiviral medication ganciclovir can help prevent the reactivation of cytomegalovirus (CMV) in adults with severe respiratory failure caused by sepsis, to see if it can improve their recovery and reduce the time they spend on a ventilator and in the ICU.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10916408

• Identifying biomarkers to predict respiratory failure after blood cell transplants

  This study is looking at certain markers in the blood to see if they can help doctors predict which patients who have had a stem cell transplant might be at risk for breathing problems, so they can take action before any serious issues arise.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10915039

• Using ganciclovir to stop cytomegalovirus from reactivating in patients with severe respiratory failure and sepsis

  This study is looking at whether the antiviral drug ganciclovir can help prevent a virus called cytomegalovirus (CMV) from coming back in adults who are seriously ill with respiratory failure from sepsis, and it’s for people who want to help improve treatment options for patients in critical condition.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10914214

• Understanding health expectations after surviving acute respiratory failure

  This study is looking at how patients who have recovered from serious breathing problems and their caregivers think about recovery, and it aims to understand the challenges they face together so that better support can be created for both groups.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10912017

Related topics

Quick answers

How many Respiratory Failure clinical trials are recruiting right now?

56, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (8 trials), China (8 trials), Canada (7 trials), Italy (6 trials), United Kingdom (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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