Condition

Critical Care clinical trials and research

• 21Clinical trials
• 87NIH research projects
• 2New in 30 days
• 13Countries

Newest Critical Care clinical trials

All recruiting trials (21)

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Deciphering why some patients stay a long time in the ICU using detailed clinical profiling

  This study will try to identify clinical patterns in adults who stay in the ICU five days or longer to better understand persistent critical illness.

  Recruiting at 6 sites Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa · Lisbon, Lisbon District and 6 other locations · NCT07510776

• Delphi consensus to guide mechanical insufflation-exsufflation use in the ICU

  A panel of ICU and lung specialists will use a structured survey process to agree on best practices for using mechanical insufflation-exsufflation to help airway clearance in critically ill patients.

  Recruiting at 4 sites Medipol University · Naples and 3 other locations · NCT07420946

• ICU rehabilitation for adults on invasive mechanical ventilation

  This project will look at rehabilitation approaches used in ICUs worldwide to see if they relate to outcomes for adults who have been on invasive mechanical ventilation for at least 48 hours.

  Recruiting Universita degli Studi di Genova · Genova, Italy · NCT07093125

• Focused ultrasound spleen stimulation for septic shock in adults

  This trial tests whether non-invasive ultrasound aimed at the spleen can help reduce inflammation in adults with septic shock.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT06990295

• Assessing breathing effort with nasal pressure during different oxygen treatments

  This study is testing if measuring nasal pressure can help doctors understand how hard patients with breathing problems are working to breathe when using different types of oxygen therapy.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT06970990

• Impact of lower vasopressor use on survival in patients with heart failure on ECMO

  This study is testing if using less vasopressor medication can help adults with heart failure on ECMO survive better over 30 days.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT06862700

• Atrial strain measurement in people with septic shock.

  This project tests whether two echocardiography software packages and an AutoStrain tool give similar left and right atrial strain results using past heart ultrasound scans from adults treated for septic shock.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT06832436

• Comparing high-flow tracheal oxygen and T-piece for breathing trials

  This study is testing whether a new type of high-flow oxygen or a standard T-piece helps patients who are coming off mechanical ventilation breathe better during trials.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT06816706

• Comparing two insulin infusion protocols for diabetic patients in ICU

  This study is testing two different insulin delivery methods to see which one helps critically ill diabetic patients in the ICU better control their blood sugar levels.

  Recruiting Suez Canal University · Ismailia · NCT06810596

• Testing different methods for setting ventilator support in ICU patients

  This study is testing two different ways to set up breathing support for ICU patients with severe breathing problems to see which one works better.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT06769360

• Using AI to Enhance Family Communication in Intensive Care

  This study is testing if using AI can help doctors in the ICU communicate better with families of patients by making it easier to summarize important conversations.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland and 1 other locations · NCT06756542

• Program to Enhance Hope in ICU Patients After Discharge

  This study is testing a follow-up program to see if talking about hope can help ICU patients feel more hopeful after they leave the hospital.

  Recruiting Oslo University Hospital · Drammen, Akershus and 2 other locations · NCT06569901

• Inspiratory-effort–targeted pressure support for adults on ventilators

  This study will test whether using inspiratory effort measured by the pressure muscle index to set pressure support helps adults with acute hypoxic respiratory failure on ventilators have better outcomes than the usual tidal volume and respiratory rate approach.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT06526598

• Monitoring glucose levels in critically ill patients

  This study looks at how often critically ill patients in the ICU experience low blood sugar and how using continuous glucose monitors can help improve their care.

  Recruiting Universidad Europea de Madrid · Madrid · NCT06234787

• Registry for patients undergoing anesthesia and critical care

  This study is collecting information from around 300,000 patients who are having anesthesia or critical care to see how their treatment affects their health and satisfaction over time.

  Recruiting Università Vita-Salute San Raffaele · Milan, MI · NCT06033404

• Measuring family engagement in intensive care units

  This study is trying to create a new tool to see how involved families are in the care of their loved ones in intensive care units and how that affects patient outcomes.

  Recruiting at 3 sites Lady Davis Institute · Calgary, Alberta and 5 other locations · NCT05659485

• Assessment of treatment strategies for stroke patients

  This study looks at different treatment methods for people who have had a stroke to see which ones help them recover better and live longer.

  Recruiting University of Giessen · Giessen, Hesse · NCT05295862

• Study on muscle weakness after surgery in intensive care patients

  This study is testing if changes in blood and muscle samples from surgical patients can help us understand and find markers for muscle weakness that happens after being in intensive care.

  Recruiting Technical University of Munich · Vienna, State of Vienna and 2 other locations · NCT03810768

• Registry of patients in the medical intensive care unit

  This study is tracking patients who stay in the medical intensive care unit to see how they recover and what their long-term health looks like after they leave the hospital.

  Recruiting Seoul National University Hospital · Seoul · NCT03216785

NIH-funded research (newest 40 of 87)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Collaborative Pediatric Critical Care Clinical Site (CPCCRN)

  A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11565056

• Collaborative Pediatric Critical Care Research Network: personalized care for septic kids

  A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.

  NIH research Children's Research Institute · Washington, United States · NIH-11564141

• Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care

  A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11564121

• Personalized care for septic children through immunomodulation in MODS

  This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11564076

• Personalized immune-based care for septic kids with organ failure

  A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11563902

• Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care

  A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11563565

• Collaborative Pediatric Critical Care Network study

  A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11562837

• Collaborative Pediatric Critical Care Network: Clinical Site

  A nationwide network study aims to tailor sepsis treatment for children with organ failure based on each child’s immune profile.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11561444

• Personalized immunomodulation for septic children in the ICU

  A pediatric critical care network is testing a personalized treatment approach for kids with sepsis-related organ failure to improve outcomes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11560824

• Collaborative Pediatric Critical Care Network: Clinical Site Supplemental

  A nationwide pediatric critical care network is testing personalized care strategies for septic children to improve outcomes.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11559170

• Personalized immune care for critically ill children with sepsis

  A multi-center effort uses rapid immune-phenotype tests to tailor treatments for children with sepsis-related organ failure.

  NIH research Central Michigan University · Mount Pleasant, United States · NIH-11557270

• Personalized immunomodulation for septic children in critical care

  A national network is testing tailored treatments for kids with sepsis-related organ failure to see if personalized care improves outcomes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11553794

• Distributional Balancing for Causal Inference in Critical Care

  A study to develop new ways to draw reliable conclusions from complex critical care data by balancing patient characteristics across treatments.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11536503

• Predictors of widespread pain after cardiac surgery

  A clinician-scientist at UNC Chapel Hill is studying why some patients develop widespread, nociplastic-like pain after heart surgery and ICU stay, to improve prevention and care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11452390

• BEACON: AI language tool to help caregivers understand what’s happening with an older family member in critical care

  A bilingual AI tool helps family caregivers of older adults in critical care understand their loved one’s medical course, using clear summaries of the hospital data in English and Spanish.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11447349

• AI-powered tools to optimize critical care pharmacist work and prevent adverse drug events

  A patient-relevant project to use artificial intelligence to help critical care pharmacists identify and prevent adverse drug events in the ICU.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11423413

• Prescriptive AI for ICU shock care: a patient-facing decision support system

  A hospital-based project aims to help ICU doctors make faster, safer decisions for patients in shock using a smart AI tool.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11393886

• Measuring ICU workload to improve safety and nurse well‑being

  A project using electronic health record data to build a real-time, multi-level model of ICU nursing workload to improve patient safety and support nurses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11347022

• MUSIC Consortium: A pathway to precision care for ARDS and critical illness

  A large, multi-site study will profile biological signals in adults with ARDS and related critical illnesses to guide personalized care.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11321096

• Metabolic testing to improve care for sepsis and ARDS

  This work uses blood metabolic testing to find patterns that could help doctors predict outcomes and tailor care for adults with sepsis and ARDS.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11263712

• Fairer ICU life-support decisions during crises using neighborhood disadvantage scores

  A new method uses neighborhood disadvantage scores to help hospitals decide which adults receive scarce ICU life-support during crises like COVID-19.

  NIH research University of Chicago · Chicago, United States · NIH-11259583

• AI to help ICU pharmacists prevent medication harms

  Using AI to predict which critically ill patients may have medication-related harms so pharmacists can intervene sooner.

  NIH research University of Georgia · Athens, United States · NIH-11187104

• Improving Care for Critically Ill Children

  This project brings together hospitals to find better ways to care for very sick children, especially those with severe infections like sepsis.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11182715

• Improving care for children with severe breathing problems

  This network brings together experts to find better ways to care for critically ill children, especially those with severe lung conditions.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11182646

• Improving Care for Critically Ill Children

  This project brings together hospitals to find better ways to care for children who are very sick or injured, especially those with serious conditions like sepsis or lung problems.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11182549

• Improving Care for Critically Ill Children

  The University of Minnesota is joining a national network to help improve care for critically ill children.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11182483

• Improving Care for Critically Ill Children

  This effort brings together medical centers to offer cutting-edge care and studies for children who are very sick.

  NIH research Duke University · Durham, United States · NIH-11181001

• Advancing Care for Critically Ill Children

  This network helps develop and test new treatments for children who are seriously ill or injured.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11180302

• Understanding Sepsis in Critically Ill Children

  This project helps us learn more about how to treat children who get very sick with infections, especially sepsis, to help them recover better.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11180282

• Improving Care for Critically Ill Children

  This project helps a network of children's hospitals work together to find better ways to care for very sick children.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11180245

• Improving Care for Critically Ill Children

  This program helps improve care for very sick children by allowing Children's Hospital of Michigan to continue participating in a national network dedicated to pediatric critical care.

  NIH research Central Michigan University · Mount Pleasant, United States · NIH-11180197

• Children's National pediatric critical care network site

  This project tests new treatments and care approaches to help critically ill children (ages 0–11), especially those with sepsis and multiple organ failure.

  NIH research Children's Research Institute · Washington, United States · NIH-11179468

• Improving Care for Critically Ill Children

  This program helps doctors at Children's Hospital of Philadelphia work together to find better ways to care for very sick children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11179178

• Improving care for children with severe infections and organ problems

  This project aims to find better ways to treat children who get very sick from infections, leading to organ problems.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11176722

• Improving Care for Seriously Ill and Injured Children

  This project brings together hospitals to find better ways to care for children who are critically ill or injured.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170743

• Improving Care for Critically Ill Children

  This project brings together many hospitals to find better ways to help children who are very sick in the intensive care unit.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170740

• Helping children with severe infections in critical care

  This effort aims to understand and improve how children fight severe infections, called sepsis, in the hospital.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170738

• Improving Care for Critically Ill Children in the ICU

  This project brings together leading children's hospitals to discover new and better ways to care for very sick children in the intensive care unit.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170735

• Improving care for critically ill children

  This project helps children who are very sick by joining a network of hospitals that work together to improve critical care.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170732

• Improving Care for Critically Ill Children

  This project helps a group of children's hospitals work together to find better ways to care for very sick children, including those with severe infections.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11170729

Related topics

Quick answers

How many Critical Care clinical trials are recruiting right now?

21, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (8 trials), Italy (3 trials), Germany (2 trials), Spain (2 trials), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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