Condition

Delirium clinical trials and research

• 50Clinical trials
• 89NIH research projects
• 17Countries

Newest Delirium clinical trials

All recruiting trials (50)

• Can citicoline help prevent cognitive decline after delirium in older adults with hip fracture?

  This study tests whether taking citicoline for 6 months after discharge helps prevent cognitive decline in adults 65 and older who had delirium during hospitalization for hip fracture.

  Recruiting Phase 2 University of Milano Bicocca · Monza, Monza E Brianza · NCT07804498

• Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults

  This pilot observational study tests whether circadian-light factors influence delirium risk in adults recovering in critical care.

  Recruiting King's College Hospital NHS Trust · London · NCT07791472

• VR-based cognitive games to help prevent delirium after big surgery

  A VR-based cognitive stimulation game is being tested to see if it can help prevent delirium in adults 65 and older after major surgery.

  Recruiting at 2 sites The Methodist Hospital Research Institute · Houston, Texas and 1 other locations · NCT07641153

• Computer-assisted cognitive stimulation for delirium in older adults

  This will try adding tablet-based cognitive exercises to sleep and mobility support to see if they reduce delirium in people aged 60 and older in subacute care.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Reus, Tarragona · NCT07563244

• Letting patients drink clear fluids until called to the operating room to shorten pre-surgery fasting

  This project will try letting elective procedure patients drink clear liquids until they're called to the operating room to see if fasting times, comfort, and perioperative outcomes improve.

  Recruiting University of Giessen · Giessen · NCT07488468

• Lemborexant to help Sleep and Delirium in older ICU patients

  This study tests whether lemborexant, a sleep medication, helps improve sleep and reduce delirium in adults 65 and older in the ICU.

  Recruiting Phase 4 Mahidol University · Bangkok · NCT07407400

• Listening to music to prevent delirium in older adults in the ICU

  This trial will try whether personalized or relaxing music, played twice daily for a week, can prevent delirium and increase days alive and free of delirium or coma in adults 65 and older in the ICU.

  Recruiting Hospital Britanico de Buenos Aires · Buenos Aires, Buenos Aires F.D. · NCT07369258

• Fecal microbiota transplant to treat ICU delirium

  This trial will test whether transferring healthy gut bacteria (fecal microbiota transplantation) can help adults in the ICU who have delirium.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07348471

• VoiceLove recorded-family-voice therapy for ICU delirium

  This study will try playing recorded messages from a loved one at the bedside to see if adults in the surgical ICU at risk for delirium can tolerate 20–25 minute sessions and find them acceptable.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT07218484

• Personalized music therapy to help prevent hospital delirium in people with Alzheimer’s, Parkinson’s, and related conditions.

  This pilot tests whether up to five personalized music therapy sessions can help prevent confusion (delirium) in hospitalized people with Alzheimer's, Parkinson's, or similar brain diseases.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT07137949

• Computer-vision detection of delirium from ICU patients' facial expressions

  This project tests whether a smartphone app using computer vision can detect delirium from facial expressions in adult neurocritical care patients.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07136207

• Delirium and cognitive changes in older adults in hospital isolation

  This study tests whether older patients kept in isolation on hospital wards have more delirium or cognitive decline than similar patients not in isolation.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07114458

• Fluvoxamine to reduce delirium after non-cardiac surgery

  This study will test whether giving fluvoxamine around the time of elective non-cardiac, non-intracranial surgery can help reduce postoperative delirium in older adults who will stay in the hospital at least two days.

  Recruiting Phase 3 Washington University School of Medicine · St Louis, Missouri · NCT06969287

• Virtual reality to improve comfort for adults in the surgical ICU

  This trial will try immersive virtual reality (HypnoVR) sessions to reduce discomfort for adults who stay at least 48 hours in the surgical intensive care unit after major cardiothoracic or abdominal surgery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06830369

• Improving hospital environments to reduce delirium in older adults

  This study is testing if improving the hospital environment to help older adults sleep better can reduce the chances of them developing delirium while they're hospitalized.

  Recruiting at 5 sites The Methodist Hospital Research Institute · Baytown, Texas and 4 other locations · NCT06736951

• Monitoring brain activity in ICU patients with sedation and delirium

  This study is testing a new brain monitoring device to see if it can help doctors better understand sedation and delirium in patients who are intubated and sedated in the ICU.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06718764

• Using melatonin to prevent delirium in hospitalized older patients

  This study is testing if melatonin can help prevent delirium in older patients aged 65 and up who are in the hospital.

  Recruiting Phase 2/3 Sultan Qaboos University · Muscat and 1 other locations · NCT06509191

• Using brain stimulation to reduce delirium in ICU patients

  This study is testing if a type of brain stimulation can help ICU patients recover from delirium faster.

  Recruiting Kuopio University Hospital · Kuopio · NCT06460363

• Combining sleep promotion and cognitive training to improve brain function in older ICU survivors

  This study is testing if helping older adults who survived ICU treatment sleep better and do brain exercises can improve their thinking skills.

  Recruiting University of Washington · Seattle, Washington · NCT06411561

• Identifying delirium in older patients with dementia in the emergency department

  This study is testing a wrist sensor to see if it can help doctors better identify delirium in older patients with dementia who come to the emergency room.

  Recruiting Ohio State University · Columbus, Ohio · NCT06326424

• Transcranial electrical stimulation for treating delirium

  This study is testing if a new type of brain stimulation can help people with delirium feel better and improve their brain activity.

  Recruiting at 2 sites UMC Utrecht · Nijmegen, Gelderland and 1 other locations · NCT06285721

• Comparing light and deep anesthesia effects on postoperative delirium and cognition in older adults

  This study is testing if using lighter anesthesia during major surgery can help older adults avoid confusion and memory problems afterward.

  Recruiting at 2 sites Auckland City Hospital · Grafton, Auckland and 2 other locations · NCT06268080

• Monitoring anticoagulation and inflammation in patients after heart and vascular surgery

  This study is trying to find the best ways to monitor blood thinning treatments in patients after major heart and vascular surgeries to improve safety and outcomes.

  Recruiting Medical University Innsbruck · Innsbruck, Tyrol · NCT06222866

• Reducing ICU Delirium with Dexmedetomidine Sleep

  This study is testing if a sleep-inducing medication called dexmedetomidine can help older patients recover better and avoid confusion after heart surgery in the ICU.

  Recruiting at 13 sites Phase 3 Massachusetts General Hospital · Los Angeles, California and 13 other locations · NCT06192615

• Improving ICU care through behavioral strategies

  This study is testing two strategies to help ICU staff use better practices for caring for critically ill adults, especially those facing health challenges, to see if it can improve patient recovery and reduce complications.

  Recruiting at 3 sites University of Nebraska · Iowa City, Iowa and 2 other locations · NCT06184945

• Automating the assessment of delirium severity in ICU patients

  This study is testing a new way to measure how severe delirium is in ICU patients over 50 by using bedside cameras and comparing it to traditional methods.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06172491

• Exploring blood markers related to delirium after heart surgery

  This study is trying to see if certain blood markers can help predict or explain delirium in patients after heart surgery.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT06007755

• Comparing two approaches to prevent delirium in hospitalized older adults

  This study tests whether involving family members in care can help prevent delirium in older adults during hospital stays better than the standard Hospital Elder Life Program alone.

  Recruiting at 7 sites University of Michigan · Orange, California and 6 other locations · NCT05929703

• Daily nurse screening for delirium in hospitalized older adults

  This study is testing if daily screenings for delirium by nurses can help improve care and outcomes for older adults in hospitals.

  Recruiting at 2 sites Penn State University · Boston, Massachusetts and 1 other locations · NCT05915377

• Evaluation of delirium data from previous patients at a clinic

  This study looks at past patient records to see what factors might cause delirium after surgery, especially in older adults and how it might differ between men and women.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT05913531

• Understanding delirium in adult and pediatric ICU patients in the Czech Republic

  This study looks at how often delirium happens and how it's managed in adult and child patients in intensive care units in the Czech Republic to see if current methods are effective.

  Recruiting Masaryk University · Brno · NCT05891873

• Using melatonin to treat delirium in critically ill adults

  This study is testing if giving melatonin to critically ill adults can help reduce the time they experience delirium while in the ICU.

  Recruiting Phase 2 Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT05713877

• Exploring brain blood flow and function in stroke, depression, dementia, and delirium

  This study is trying to see how different imaging techniques can help us understand blood flow in the brain of people with stroke, depression, dementia, and delirium, as well as healthy individuals.

  Recruiting University of Leicester · Leicester, Leicestershire and 1 other locations · NCT05649800

• Using virtual reality to reduce delirium in ICU patients

  This study is testing if using virtual reality to connect ICU patients with their families can help reduce confusion and improve their recovery while they are on a ventilator.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05525702

• Using nerve blocks to reduce pain and improve recovery in older adults after spinal surgery

  This study is testing if a special nerve block can help older adults feel less pain and recover better after spinal surgery.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT05461092

• Managing agitated delirium in cancer patients with neuroleptics and anti-epileptics

  This study is testing if certain medications can help calm down cancer patients who are experiencing agitation and confusion while in the hospital.

  Recruiting Phase 2/3 M.D. Anderson Cancer Center · Houston, Texas · NCT05431595

• Study on complications and long-term outcomes after high-risk surgeries

  This study is trying to see how well we can predict and identify complications in patients having high-risk surgeries by monitoring them closely after their operations.

  Recruiting UMC Utrecht · Utrecht · NCT05331118

• Using Dexmedetomidine to Reduce Delirium After Awake Brain Surgery

  This study is testing if a medication called dexmedetomidine can help prevent confusion after brain surgery in patients who are awake during the procedure.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05195034

• Using AI and sensors to monitor critically ill patients in the ICU

  This study is testing whether using AI and sensors can help doctors better monitor and understand the health of critically ill patients in the ICU.

  Recruiting University of Florida · Gainesville, Florida · NCT05127265

• A program to reduce postoperative delirium in older surgical patients

  This study is testing a program to see if special education and care can help prevent confusion after surgery in older patients aged 60 and above.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05114876

• Analyzing cerebrospinal fluid in patients with delirium

  This study is trying to find out if certain markers in the spinal fluid of people with delirium, especially those who have had hip fractures, can help us understand how delirium is connected to dementia.

  Recruiting Oslo University Hospital · Oslo, Other · NCT05060614

• Collecting data on delirium using EEG monitoring

  This study is trying to see how EEG monitoring can help track and understand different types of delirium in patients in the Intensive Care Unit.

  Recruiting Ceribell Inc. · Stanford, California and 6 other locations · NCT04962815

• Monitoring brain activity to understand delirium after heart surgery

  This study tests how monitoring brain activity can help us understand and predict delirium in patients with normal thinking skills after heart surgery.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT04832568

• Understanding brain health in ICU patients with kidney injury

  This study looks at how kidney injury affects brain health in critically ill adults in the ICU to see if measuring brain oxygen levels can help predict long-term thinking and memory problems.

  Recruiting Queen's University · Kingston, Ontario · NCT04722939

• Combining cycling and cognitive training for ICU survivors

  This study is testing whether a 12-week program that combines cycling and brain exercises can help improve thinking skills and quality of life for middle-aged people who have survived an ICU stay with delirium.

  Recruiting University of Missouri, Kansas City · Kansas City, Missouri · NCT04556227

• Effects of Remimazolam on outcomes after bladder cancer surgery

  This study tests whether a new anesthesia called remimazolam can improve recovery and reduce complications for patients having surgery for bladder cancer compared to traditional anesthetics.

  Recruiting at 6 sites Phase 4 Peking University First Hospital · Beijing, Beijing Municipality and 5 other locations · NCT04532606

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

• Monitoring brain activity to understand delirium in children after surgery

  This study is testing how brain activity can help us understand and predict delirium in children under 16 after they have surgery.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT04091724

• Monitoring nocturnal oxygen levels in older patients after hip surgery

  This study is testing if monitoring oxygen levels at night can help understand and possibly prevent confusion in older patients after hip surgery.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT04007432

• Understanding brain activity and postoperative delirium in older patients

  This study is trying to see how brain activity before surgery affects the chances of older patients developing confusion after major surgery.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT03124303

NIH-funded research (newest 40 of 89)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• READI-SET-GO: Improving Delirium Screening for Hospitalized Older Adults

  A hospital-based program tests how well routine nurse delirium screening using UB-CAM works when integrated into the electronic health record to improve outcomes for older patients.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11570146

• Continuous wearable monitor with AI to prevent agitation and delirium in hospitalized older adults

  A wearable sensor and AI system will continuously track agitation in older hospital patients to help prevent delirium and protect brain health.

  NIH research Healthy Design, LTD. Co. · Rutland, United States · NIH-11530759

• Low brain changes from anesthesia may signal early Alzheimer's risk

  A study at Stanford will look at whether brain responses to anesthesia during surgery reveal early brain changes linked to Alzheimer’s disease and delirium risk in people aged 65 and up.

  NIH research Stanford University · Stanford, United States · NIH-11528116

• Why dementia and sudden confusion (delirium) often happen together

  This project looks at brain electrical signals and chemical changes to find why people with dementia sometimes develop sudden confusion called delirium.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11480981

• AKI-related delirium after heart surgery

  This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.

  NIH research University of Iowa · Iowa City, United States · NIH-11477480

• Lipocalin-2 and delirium after surgery in Alzheimer’s disease and related dementias

  A study at Duke University looks at how an inflammatory protein called lipocalin-2 may trigger delirium after surgery, especially in people at risk for Alzheimer’s and related dementias.

  NIH research Duke University · Durham, United States · NIH-11464607

• Digital marker to measure delirium severity in ICU patients

  A Mayo Clinic-led study will test a passive digital tool to measure how severe delirium is in adults in the ICU, with the goal of helping clinicians intervene earlier.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11445921

• Post-Stroke Delirium: How it Behaves and What It Means for Recovery

  This project looks at delirium that happens after a stroke and how different symptoms and illness courses relate to recovery and long-term outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11425377

• Commercialization of an EEG-guided anesthesia system to reduce delirium in older adults and those at risk for Alzheimer’s

  A new wireless EEG-guided anesthesia system aims to reduce postoperative delirium in seniors and people with or at risk for Alzheimer’s by personalizing brain monitoring during surgery.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11419843

• Brain circuits behind confusion after surgery in early Alzheimer's

  This project looks at whether activating two tiny brain centers can prevent or shorten sudden confusion after anesthesia in people with early Alzheimer's.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11401193

• Serum drug levels and metabolism to shorten delirium and protect memory in older adults

  This research tests whether measuring serum levels of psychotropic drugs and how people metabolize them can help shorten delirium and protect long-term thinking in adults aged 65 and older who are hospitalized.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11400417

• Delirium after surgery and its link to Alzheimer's and related dementias

  This project looks at why older adults and people with or at risk for Alzheimer's can get delirium after surgery and how that might increase later dementia risk.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11395067

• Fluvoxamine to prevent delirium after non‑cardiac surgery

  Seeing if taking the antidepressant fluvoxamine around non‑cardiac surgery can lower inflammation and reduce the chance or severity of postoperative delirium in adults, including those with Alzheimer‑type dementia.

  NIH research Washington University · Saint Louis, United States · NIH-11383660

• Emergency delirium recovery in older surgical patients treated with collaborative care

  A program tests a team-based care approach to help older patients recover from delirium after emergency general surgery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11382959

• Intraoperative EEG-Guided Anesthesia to Reduce Delirium in Older Adults and Those with Alzheimer’s or Related Dementias

  A new system uses brainwave monitoring during surgery to tailor anesthesia and reduce delirium risk in older patients and those with Alzheimer’s disease or related dementias.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11382203

• Postoperative recovery: how pain, delirium, and brain inflammation are linked

  A study exploring how immune cells in the body and brain influence recovery after surgery, especially pain and delirium, to help patients recover faster.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11377422

• Understanding how blood biomarkers link delirium after surgery to Alzheimer’s disease

  This study tests whether blood markers of Alzheimer's disease can predict and explain delirium after surgery in older adults.

  NIH research Duke University · Durham, United States · NIH-11374271

• READI-SET-GO: Faster delirium detection to support geriatric care

  Aimed at older adults, this project tests a quick screening approach to find delirium early in hospitals to help prevent harm and improve outcomes.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11373018

• Neuroinflammation, Protective Brain Scaffolds, and Delirium After Surgery

  This project looks at why older people often get delirium after surgery and how brain tissues called perineural nets might influence this, with the goal of improving outcomes for people at risk of Alzheimer’s-related conditions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11345862

• Machine learning to detect and predict delirium in hospitalized older adults

  A doctors and researchers team will use computer models to spot delirium in older adults in the hospital and predict who might develop it, helping prevent problems.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11341647

• Integrated Brain State Monitor to Help Personalize Anesthesia and Prevent Delirium in Older Adults

  A new, brain-monitoring system aims to personalize anesthesia care for older adults and people at risk for Alzheimer's, with the goal of reducing postoperative delirium.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11333063

• VoiceLove: A patient-facing app to reduce ICU delirium and boost family engagement for people with Alzheimer's and related dementias

  A patient-facing app helps families and ICU teams work together to prevent delirium in people with Alzheimer’s and related dementias.

  NIH research Voicelove INC. · Scarsdale, United States · NIH-11330598

• DNA markers to predict delirium and lasting memory problems after surgery in older adults with dementia

  This project looks for DNA-based signals that might help identify older adults with Alzheimer’s or dementia who are likely to get delirium or long-term thinking problems after surgery.

  NIH research Stanford University · Stanford, United States · NIH-11321269

• Improving medication plans after hospital delirium for people with Alzheimer's and related dementias

  This project will build data-driven tools to help clinicians safely stop or tailor antipsychotic medicines after a hospital episode of delirium in people with Alzheimer's and related dementias.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11320818

• Tailoring blood pressure to protect brain blood flow during and after heart surgery

  Aims to see if monitoring each person's brain blood-flow limits and personalizing blood-pressure targets during and after heart surgery reduces delirium and longer-term memory and thinking problems.

  NIH research Stanford University · Stanford, United States · NIH-11310140

• Spinal fluid and blood tests to understand delirium and thinking problems after surgery

  This project looks at spinal fluid and blood markers from adults having surgery to learn why some develop delirium and longer-term thinking problems.

  NIH research Stanford University · Stanford, United States · NIH-11309642

• Preventing confusion after heart surgery with acetaminophen

  This project is looking at whether giving older patients acetaminophen regularly after heart surgery can help prevent confusion and disorientation.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11302871

• How surgery-related inflammation affects brain blood vessels in people with dementia

  This project aims to find how inflammation from surgery harms the brain's blood vessels and leads to sudden delirium in older adults with dementia.

  NIH research Duke University · Durham, United States · NIH-11297670

• From Cells to Society: Epigenetics and Brain Vulnerability to Delirium and Cognitive Decline

  Researchers will study how DNA methylation patterns (epigenetics) relate to a “vulnerable brain” that could lead to delirium and cognitive decline, especially after major surgery.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11275332

• Monitoring brain activity to improve anesthesia for elderly patients at risk of delirium

  This study is working on a new system that helps doctors give safer anesthesia to older patients, especially those at risk for Alzheimer's and similar conditions, by keeping an eye on their brain activity to lower the chances of confusion after surgery.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11273457

• Why delirium comes and goes in older adults

  Researchers will use continuous sleep and activity monitoring in hospitalized older adults to find patterns that link sleep-wake and circadian disturbances with episodes of delirium.

  NIH research Northwestern University · Chicago, United States · NIH-11263746

• How delirium and dementia overlap in the brain

  This project looks at brain electrical signals and chemicals to understand why people with dementia sometimes develop sudden confusion called delirium.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11241121

• How brain immune cells and amyloid contribute to delirium in dementia

  This project uses a gentle, noninvasive vagus nerve stimulation to try to reduce brain inflammation and amyloid buildup after surgery in people with Alzheimer’s-type dementia.

  NIH research Duke University · Durham, United States · NIH-11239019

• Proteomic signatures linking delirium, aging, and Alzheimer's risk

  The team looks for blood protein patterns that predict which older adults may get sudden confusion after surgery and which people later have lasting memory decline or dementia.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11238069

• How genes and inflammation may raise risk for delirium and Alzheimer's in older adults

  This project looks at whether older adults with higher genetic risk for Alzheimer's plus inflammation from events like surgery or infection are more likely to get delirium, faster memory decline, or dementia.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11237979

• An app to improve communication and family engagement for critically ill patients with delirium

  This study is testing a new app called VoiceLove that helps families communicate better with healthcare providers about loved ones in the ICU, especially those with Alzheimer's and related dementias, to reduce confusion and improve their care.

  NIH research Voicelove LLC · Scarsdale, United States · NIH-11222806

• Fluvoxamine to reduce delirium after non-cardiac surgery

  This project gives fluvoxamine around non-cardiac surgery to adults with Alzheimer-type or related dementias to try to lower the chance or severity of postoperative delirium.

  NIH research Washington University · Saint Louis, United States · NIH-11189815

• Gut bacteria that may protect older adults' brains from confusion after surgery

  This project looks at whether certain gut bacteria and the compound they make (indole-3-propionic acid, IPA) help protect older adults from confusion after surgery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11177632

• Understanding how epigenetics affects delirium and cognitive decline in elderly patients with dementia

  This study is looking at how changes in our genes might help us understand the risk of confusion and memory problems after surgery in older adults with dementia, so we can find better ways to spot and help those who might be at risk.

  NIH research Stanford University · Stanford, United States · NIH-11174306

• Investigating the link between brain inflammation and postoperative delirium in older adults

  This study is looking at how inflammation in the brain during surgery might lead to confusion and memory problems afterward, especially in older adults, and it will check how certain brain structures are affected to help understand these changes better.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11158613

Related topics

Quick answers

How many Delirium clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (19 trials), China (8 trials), Canada (4 trials), Germany (3 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2/3: 2, Phase 3: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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