Metabolism and muscle recovery after an ICU stay

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center study recruits adults who survived a critical illness with an anticipated ICU stay of seven days or more and elective major abdominal surgery patients as a comparison group. Investigators will collect blood samples for inflammation markers, nucleosomes, erythrocyte membrane fatty acids, and myokines, and measure resting energy expenditure. Muscle performance will be measured at discharge and followed over three months, with muscle biopsies, bioelectrical impedance, and indirect calorimetry used when feasible. The goal is to link metabolic and neuroendocrine profiles to trajectories of muscle function after ICU discharge.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Critical illness:
* anticipated ICU stay \>= 7 days
* Major abdominal surgery
* elective surgery

Exclusion Criteria:

* Active malignancy
* Inherited metabolic disorder
* Known muscle disease
* Pregnancy
* Patient refusal
* Patient unable to express informed consent (dementia, confusion)
* Known coagulation disorder (cirrhosis, genetic coagulopathy) or thrombocytopenia \< 100,000/mm³ on the day of biopsy, anemia with hemoglobin \< 9 g/dL on the day of biopsy, or treatment with anticoagulant agents (contraindication to muscle biopsies only)
* Pacemaker or other implanted electronic device (contraindication to bioelectrical impedance analysis only)
* Oxygen therapy (contraindication to indirect calorimetry during spontaneous ventilation)

Where it's running

• CHU Sart Tilman
  Liège, Belgium Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.