Characterizing patients treated at internal medicine clinics

Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics

IRCCS San Raffaele · NCT05780099

This study looks at patients with serious health issues treated in internal medicine clinics to see how their different conditions affect their care and to find better ways to diagnose and treat them.

Quick facts

Study typeObservational
Enrollment50000 (estimated)
Ages18 Years and up
SexAll
SponsorIRCCS San Raffaele (other)
Locations2 sites (Milan and 1 other locations)
Trial IDNCT05780099 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify demographic, clinical, laboratory, and radiological markers of disease severity and activity in patients with various conditions treated at internal medicine wards. It focuses on complex and fragile patients suffering from respiratory, cardiovascular, infectious, immunological diseases, and critical illnesses. The study seeks to improve diagnosis, monitoring, and treatment processes by optimizing management strategies tailored to specific diseases. By analyzing the coexistence of these conditions, the research aims to establish more effective diagnostic and therapeutic algorithms.

Who should consider this trial

Good fit: Ideal candidates include patients receiving treatment for respiratory, cardiovascular, infectious, immunological diseases, or those classified as frail at San Raffaele Hospital.

Not a fit: Patients who refuse to participate or are enrolled in other interventional studies may not benefit from this research.

Why it matters

Potential benefit: If successful, this study could lead to improved management and treatment outcomes for patients with complex internal medicine conditions.

How similar studies have performed: While similar studies have been conducted, this approach focuses on a comprehensive characterization of multiple overlapping conditions, making it a novel endeavor.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Receving treatment at internal medicine departments (inpatient, outopatient, day hospital) of San Raffaele Hospital
* at least one suspected or confirmed diagnosis among:

  1. immune mediated disorder
  2. respiratory disorder
  3. metabolic disorder
  4. sepsis
  5. rare disorder (according to Italian Ministry of Health list)
  6. pregnancy-related disorder
  7. frailty defined as: either ≥2 CIRS (Cumulative Illness Rating Scale) Severity Index 10 or ≤70% Karnofsky scale

Exclusion Criteria:

* refusal to participate
* enrolment in other intervantional study

Where this trial is running

Milan and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Respiratory Disease, Cardiovascular Diseases, Infectious Disease, Critical Illness, Immunological Disease, Pregnancy Disease, Metabolic Syndrome, Chronic Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.