Evaluating muscle weakness in ICU survivors through exercise testing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the impact of sepsis and shock on microcirculation in ICU patients, which can lead to long-term muscle weakness known as ICU-acquired weakness (ICU-AW). It involves four follow-up assessments after ICU discharge at 7 days, 3 months, 6 months, and 12 months to evaluate microvascular function using high-resolution near-infrared spectroscopy (NIRS). The study aims to characterize how microvascular dysfunction affects exercise limitations in survivors of intensive care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.

Exclusion Criteria:

* Unable to provide consent
* Trajectory of health expected to be significantly limited in the upcoming 12 months
* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity
* have significant orthopedic or musculoskeletal impairment affecting mobility
* have a medical history of neuromuscular disease
* ongoing respiratory limitations (i.e., supplemental oxygen)
* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)
* a body mass index (BMI) of ≥ 40 kg/m2 (impacting NIRS signal due to adipose tissue thickness)
* if participant's primary residence is a significant distance from the participating study site

Where it's running

• St. Boniface General Hospital
  Winnipeg, Manitoba, Canada Recruiting
• Health Sciences Centre Winnipeg
  Winnipeg, Manitoba, Canada Recruiting

Study contacts

• Principal investigator: Asher Mendelson, MD PhD — University of Manitoba
• Study coordinator: Asher Mendelson, MD PhD
• Email: Asher.Mendelson@umanitoba.ca
• Phone: 204-787-1634

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.