Negative-pressure versus positive-pressure breathing after LVAD implantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Stable patients who have just received a durable left ventricular assist device and are monitored with a pulmonary artery catheter undergo two ventilation modes: 15 minutes of extra-thoracic negative pressure ventilation and usual intrathoracic positive-pressure ventilation. Hemodynamic parameters including right ventricular function, pulmonary artery pressures, and cardiac output are recorded via the pulmonary artery catheter and compared between the two modes. Patients with intraoperative complications, unstable circulation or ventilation, inability to fit the cuirass, or unavailable investigators are excluded. The protocol aims to determine immediate hemodynamic effects of changing intrathoracic pressure support in the early postoperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients after implantation of a durable left ventricular assist device

Exclusion Criteria:

* Complication during surgery like bleeding, emergency, inability to fit the cuirass, unavailability of an investigator, unstable condition regarding circulation or ventilation

Where it's running

• Klinikum Karlsburg
  Karlsburg, Germany Recruiting

Study contacts

• Study coordinator: Matthias Heringlake, Prof. Dr. med.
• Email: Heringlake@drguth.de
• Phone: 038355 70-2500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.