Using Vasopressin to Prevent Kidney Injury in ICU Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study is a multicenter, placebo-controlled, double-blind, randomized clinical trial aimed at evaluating the feasibility of using vasopressin to prevent acute kidney injury in critically ill patients admitted to intensive care units (ICUs). The study will include 60 adult patients across 3 to 4 Brazilian hospitals, focusing on those at high risk for renal dysfunction. By assessing adherence to the protocol and monitoring potential adverse effects, the study seeks to provide insights that could lead to larger trials and improved renal outcomes in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years old);
* Admitted to intensive care units;
* Predicted risk of acute kidney injury calculated based on clinical and laboratory data at ICU admission and is considered eligible if the value in the calculator is equal or greater than 5 points;

Exclusion Criteria:

* Time since admission to the ICU greater than 24 hours;
* Use of vasopressors at the time of inclusion;
* MAP \>90 mmHg;
* Hyponatremia (\<130 mmol/L);
* Severe TBI with Glasgow Coma Scale \< 8;
* Elective surgeries;
* Dialysis chronic kidney disease or acute kidney injury who received renal replacement therapy upon admission or are expected to receive renal replacement therapy within the next 24 hours;
* Suspected or confirmed acute mesenteric ischemia;
* Prospect of death in less than 24 hours;
* Medical team not committed to full investment at the time of inclusion;
* Prior inclusion in the study;
* Pregnancy.

Where it's running

• Matheus Liguori Feliciano da Silva
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Matheus Silva — Hospital do Coracao
• Study coordinator: Matheus Silva
• Email: matheus_liguori@hotmail.com
• Phone: +55 11 98282-3920

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.