Fluorescent Probe for Real-Time Kidney Function in Critically Ill Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional phase 4 study evaluates the tGFR device, Relmapirazin, Iohexol, and the Medibeacon tGFR monitor against traditional urine collection and creatinine-based methods. It aims to determine how well the real-time transdermal GFR measurement aligns with accepted kidney function assessments in hospitalized, acutely ill patients. Participants are adults 18-65 who are critically or acutely ill and admitted to the ICU, with stable renal function. The study explores whether real-time kidney monitoring can improve dosing of renally eliminated medications in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-65 years old
* critically ill or acutely ill hospitalized patients admitted to the intensive care unit
* Stable/normal renal function

Exclusion Criteria:

* Prisoners
* Pregnant women
* Laboratory evidence of unstable kidney function (KDIGO AKI stage 1-3--This includes subjects with Scr \> 1.5x baseline)

Where it's running

• UKHealthCare/University of Kentucky
  Lexington, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Aaron M Cook, PharmD — University of Kentucky College of Pharmacy, Department of Pharmacy Practice & Science
• Study coordinator: Aaron Cook, PharmD
• Email: amcook0@uky.edu
• Phone: 18592578444

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.