Condition

Cardiogenic Shock clinical trials and research

• 72Clinical trials
• 3NIH research projects
• 1New in 30 days
• 26Countries

Newest Cardiogenic Shock clinical trials

All recruiting trials (72)

• Factors Influencing Outcomes in ECMO and Impella Patients

  This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT07885618

• Evaluating a noninvasive tissue sensor to detect cardiogenic shock earlier in heart patients

  This pilot, noninvasive study tests whether the NIRSense wearable can help detect deterioration in adults with cardiogenic shock risk due to heart attack or heart failure.

  Recruiting NIRSense Inc. · Weston, Florida · NCT07825363

• Safety and Efficacy of an Extracorporeal Ventricular Assist System for Cardiogenic Shock

  This study tests whether an extracorporeal ventricular assist device can safely provide short-term heart support and help patients with cardiogenic shock or trouble weaning from bypass.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07769528

• Left Ventricular Support and Advanced Monitoring in AMI–Cardiogenic Shock: Immediate Impella Use and PAC/Monitoring vs Standard Care

  In adults with heart attack-related cardiogenic shock, this trial tests whether using an Impella left ventricular assist device and/or protocolized pulmonary artery catheter monitoring improves survival compared with standard care.

  Recruiting Leipzig Heart Science gGmbH · Leipzig, Saxony · NCT07762560

• CRP Apheresis for infarct-related cardiogenic shock

  This study tests whether selectively removing C-reactive protein with apheresis, in addition to standard care, helps people with cardiogenic shock after a heart attack.

  Recruiting Leipzig Heart Science gGmbH · Leipzig, Saxony · NCT07687017

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• BEAT-SHOCK: Baseline Registry for Acute Cardiogenic Shock at Basel

  This registry collects and shares data on adults with cardiogenic shock admitted to University Hospital Basel to help understand how these patients are treated and how they fare.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07643610

• Optimizing Impella 5.5 Outcomes With Advanced Data Science

  This study tests whether real-world data from Impella 5.5 patients with cardiogenic shock can help predict heart recovery and prevent complications, using advanced data science.

  Recruiting Medical University of Vienna · Vienna · NCT07619144

• Cardiogenic Shock Outcomes Registry (COR-SHOCK): how patients fare over time

  This observational registry tests how outcomes and management of cardiogenic shock have changed over the years in adults receiving routine care.

  Recruiting Hospital de Santa Cruz, Portugal · Carnaxide, Lisbon District · NCT07597291

• Istaroxime for Stabilization in Acute Heart Failure with Cardiogenic Shock

  A randomized trial tests whether istaroxime helps adults with cardiogenic shock from acute heart failure more than a placebo, and whether it is safe to use.

  Recruiting Phase 2/3 Seismic Pharmaceuticals Operations LLC · Yerevan · NCT07583446

• Norepinephrine vs Dopamine as the First Vasoactive Drug in Cardiogenic Shock

  This trial tests whether norepinephrine or dopamine works better and is safer as the first drug given to adults with cardiogenic shock.

  Recruiting Chonnam National University Hospital · Gwangju, Jeollanam-do · NCT07562932

• Left ventricular unloading with a micro-axial pump after heart surgery for post-cardiotomy cardiogenic shock

  This trial tests the SynFlow Duro left ventricular support device in adults who cannot be weaned from bypass or have severe shock after heart surgery.

  Recruiting at 2 sites ForQaly Medical (Shanghai) Co., Ltd · Fuzhou, Fujian and 1 other locations · NCT07560085

• Prolonged nasogastric ketone infusion for decompensated heart failure

  This will test whether a continuous nasogastric infusion of a ketone (D‑beta‑hydroxybutyrate) can safely reach target blood levels in adults with severely reduced ejection fraction admitted for acute decompensated heart failure or cardiogenic shock.

  Recruiting Phase 4 Institute for Clinical and Experimental Medicine · Prague, Prague · NCT07527156

• Multimodal profiling of adults hospitalized with acute heart failure and cardiogenic shock

  This project will test whether combining routine hospital data with extra blood and urine samples can help doctors identify types of cardiogenic shock and predict 30-day outcomes in adults hospitalized with acute heart failure.

  Recruiting at 4 sites University Heart Center Freiburg - Bad Krozingen · Bad Krozingen and 3 other locations · NCT07515508

• Characterizing phenotypes of acute heart failure

  This project will try to see if heart function measures, imaging features (radiomics), and blood biomarkers can predict outcomes for adults hospitalized with acute heart failure, including cardiogenic shock.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07508891

• Ventilation settings and acid-base balance after cardiac arrest or cardiogenic shock

  This study tests how different initial ventilator settings align with a decision-support algorithm to see if acid-base imbalances can be reduced in adults with cardiac arrest or cardiogenic shock on mechanical ventilation.

  Recruiting Laval University · Québec, Quebec · NCT07484828

• Routine versus provisional distal perfusion catheter placement during mechanical circulatory support

  This study tests whether placing a distal perfusion catheter routinely or only provisionally improves limb outcomes in patients needing femoral artery support for mechanical circulatory support.

  Recruiting Samsung Medical Center · Changwon and 5 other locations · NCT07482865

• Arterial compliance and response to intra-aortic balloon counterpulsation in cardiogenic shock

  This project will see if baseline arterial compliance (stroke volume/pulse pressure) predicts which adults in cardiogenic shock benefit from intra-aortic balloon counterpulsation.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07402018

• On-scene extracorporeal CPR (ECPR) in Ostrava

  This tests doing ECMO (ECPR) at the scene for people ≤70 with witnessed out-of-hospital cardiac arrest who received bystander CPR to see if starting ECMO faster helps them survive with good brain function.

  Recruiting at 2 sites University Hospital Ostrava · Ostrava, Moravian-Silesian Region and 1 other locations · NCT07374289

• Personalized mean arterial pressure targets guided by central venous pressure for adults with cardiogenic shock

  This will test whether setting each adult cardiogenic shock patient's blood pressure target based on their central venous pressure helps organs recover and improves survival compared with standard MAP targets.

  Recruiting at 2 sites CMC Ambroise Paré · Amiens and 10 other locations · NCT07345559

• Pre-emptive LAVA-ECMO support for complex, high-risk TAVR

  The team will try pre-emptive left atrial veno-arterial ECMO to stabilize adults with severe aortic stenosis undergoing complex, high-risk TAVR who are unstable or at risk of instability.

  Recruiting at 2 sites Atlantic Health System · Detroit, Michigan and 1 other locations · NCT07309029

• Magenta Elevate™ device for cardiogenic shock

  This trial tries the Magenta Elevate™ device to see if it can safely support people with cardiogenic shock caused by left ventricular failure.

  Recruiting at 8 sites Magenta Medical Ltd. · Tbilisi and 7 other locations · NCT07293923

• Life after hospital for cardiogenic shock survivors

  This project follows adults who survived cardiogenic shock after hospital discharge to see how they recover and what care they need.

  Recruiting Mackay Memorial Hospital · Taipei · NCT07266675

• Temporary heart support with the iVAC 2L device during high-risk coronary procedures

  This trial will try the iVAC 2L temporary heart‑support device during high‑risk PCI to help people with severe coronary artery disease stay hemodynamically stable through the procedure.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT07149714

• Empagliflozin’s Microcirculation Effects in Cardiogenic Shock

  This ancillary pilot study tests whether empagliflozin given to patients in the ICU with cardiogenic shock can improve the tiny blood vessels’ flow, as measured in real time.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07141355

• Hemodynamic resuscitation with a Swan-Ganz catheter in cardiogenic shock.

  This will try using a Swan‑Ganz (pulmonary artery) catheter to guide medicines and fluids in adults who have cardiogenic shock after a heart attack.

  Recruiting Bach Mai Hospital · Hanoi · NCT07062744

• Co-designed pain and sedation protocol for adults on ECMO

  This project will test a co-designed pain and sedation plan to see if it's acceptable for adults receiving ECMO and similar ventilated ICU patients.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT07032987

• Initiation and Titration of GDMT with Impella 5.5 in Heart Failure with Cardiogenic Shock

  This study tests a device-plus-drug strategy using the Impella 5.5 alongside optimized guideline-directed medical therapy to see if heart recovery improves in adults with decompensated heart failure and cardiogenic shock.

  Recruiting at 2 sites Abiomed Inc. · Tampa, Florida and 16 other locations · NCT06965504

• Efferon CT hemoadsorption for cardiogenic shock after a heart attack

  This trial will test whether using the Efferon CT blood‑filtering device in patients who develop cardiogenic shock within hours of a heart attack can lower harmful inflammation and help prevent organ failure.

  Recruiting Efferon JSC · Tomsk · NCT06955936

• Impact of lower vasopressor use on survival in patients with heart failure on ECMO

  This study is testing if using less vasopressor medication can help adults with heart failure on ECMO survive better over 30 days.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT06862700

• Understanding cardiogenic shock in patients admitted to intensive care

  This study looks at how common cardiogenic shock is in patients in intensive care and what happens to them based on their age, sex, and the cause of their condition.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06827314

• Using cangrelor to improve outcomes in patients with cardiogenic shock on ECMO

  This study is testing if adding a medication called cangrelor can help patients in cardiogenic shock on ECMO have better outcomes while reducing bleeding risks during their treatment.

  Recruiting Phase 2 IRCCS San Raffaele · Milan, Italy · NCT06792643

• Registry of diagnostics and treatment outcomes in patients with cardiogenic shock in Poland

  This study is collecting information on how patients with cardiogenic shock are diagnosed and treated in Poland to see how well current treatments work and where improvements can be made.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship and 1 other locations · NCT06697093

• Early versus standard continuous dialysis for adults with cardiogenic shock on VA‑ECMO

  We will test whether starting continuous dialysis earlier helps adults with cardiogenic shock and moderate-to-severe acute kidney injury who are on veno-arterial ECMO, compared with the usual timing.

  Recruiting Phase 4 Samsung Medical Center · Seoul and 1 other locations · NCT06696235

• Evaluating the Rockwood Clinical Frailty Score in patients with cardiogenic shock

  This study is testing if the Rockwood Clinical Frailty Score can help doctors better predict outcomes for adults in the ICU who are experiencing cardiogenic shock.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06692855

• Early transcatheter aortic valve replacement for critical aortic stenosis with cardiogenic shock

  This study will test whether doing a transcatheter aortic valve implantation within 12 hours helps people with critical aortic stenosis and cardiogenic shock survive and recover better than stabilizing them first and treating later.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen O · NCT06638268

• Rehabilitation for patients recovering from cardiogenic shock

  This study is testing how well cardiac rehabilitation helps people recover and improve their quality of life after experiencing cardiogenic shock.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan · NCT06572826

• Examining outcomes in STEMI patients with cardiogenic shock in Abu Dhabi

  This study looks at the health outcomes of patients in Abu Dhabi who had a serious heart attack complicated by shock to see how different treatments and patient factors affect their recovery.

  Recruiting at 2 sites Abu Dhabi Health Services Company · Abu Dhabi, Abu Dhabi Emirate and 1 other locations · NCT06535503

• Italian pilot program to speed referral and care for cardiogenic shock patients

  This program will try a shared hub-and-spoke cardiogenic shock protocol to see if faster referral to specialized centers lowers 30-day deaths for adults with AMI-related cardiogenic shock (SCAI B–D).

  Recruiting at 16 sites Fondazione GISE Onlus · Chivasso and 15 other locations · NCT06475456

• Evaluating cardiac output measurement methods in critically ill patients on life support

  This study is testing if a method that measures energy use can accurately estimate heart function in critically ill patients on life support.

  Recruiting Universität Münster · Münster · NCT06369818

• Comparing VA ECMO with and without left ventricular unloading in cardiogenic shock patients

  This study is testing if adding a device to help the heart pump better while on a life-support machine can improve recovery for people in cardiogenic shock.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT06336655

• Observational study on cardiac output measurement in patients with cardiogenic shock

  This study is testing new ways to measure how well the heart is pumping in critically ill patients using special devices to see if it can help improve their care.

  Recruiting Abiomed Inc. · Aachen, North Rhine-Westphalia and 3 other locations · NCT06308055

• Assessing muscle thickness changes in heart failure patients

  This study is testing how muscle thickness changes in heart failure patients receiving advanced treatments like heart transplants or assist devices to see how it affects their recovery.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT06253104

• Registry of patients with acute cardiovascular diseases in Naples

  This study looks at how patients with serious heart problems are treated and what happens to them while they are in the hospital and after they go home.

  Recruiting Federico II University · Naples · NCT06162247

• Registry of patients with acute cardiovascular disease in a cardiac intensive care unit

  This study is looking at patients with serious heart conditions in the Cardiac Intensive Care Unit to see how they do during and after their hospital stay.

  Recruiting University Hospital, Ioannina · Ioannina, Epirus · NCT06081205

• Cardiohelp ECMO support for children with severe cardiac failure

  This study will test the Cardiohelp VA-ECMO system for up to 30 days and try heparin versus bivalirudin as anticoagulants in children (0–16 years) with severe heart failure who need VA-ECMO.

  Recruiting at 5 sites Phase 2 Stanford University · Palo Alto, California and 4 other locations · NCT06080074

• Using a pulmonary artery catheter and early carvedilol treatment for cardiogenic shock in heart failure patients

  This study is testing if using a special heart monitor along with early treatment with carvedilol can help heart failure patients in cardiogenic shock live longer and need less medication.

  Recruiting Asan Medical Center · Seoul · NCT06078436

• Effects of left ventricular unloading during VA ECMO support

  This study is testing whether using an intra-aortic balloon pump along with VA ECMO support can help patients with heart failure recover better than just using VA ECMO alone.

  Recruiting at 7 sites Erasmus Medical Center · Bruges and 13 other locations · NCT05913622

• Early use of Empagliflozin in patients with cardiogenic shock

  This study tests if starting a diabetes medication called Empagliflozin early can help people in cardiogenic shock feel better and improve their chances of recovery.

  Recruiting at 5 sites Phase 3 Central Hospital, Nancy, France · Ars-Laquenexy and 7 other locations · NCT05879276

• Observing the course of cardiogenic shock in critical care patients

  This study looks at patients in critical care with cardiogenic shock to see how their heart function changes and how it affects their chances of recovery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05752383

• Understanding genetic factors in cardiogenic shock outcomes

  This study is trying to see how genetic differences affect recovery and treatment success in patients with cardiogenic shock after a heart attack.

  Recruiting Barts & The London NHS Trust · London · NCT05728359

• Assessing Cardiac Function in Heart Failure Patients

  This study is testing if a heart medication called milrinone can improve heart function and outcomes for people with heart failure who need advanced treatments.

  Recruiting Early Phase 1 University of Chicago · Chicago, Illinois · NCT05700617

• Comparing individualized and conventional blood transfusion strategies during ECMO for heart failure

  This study is testing whether a personalized blood transfusion approach during heart support treatment can help patients use less blood and have better outcomes compared to the standard method.

  Recruiting at 4 sites Phase 1 University Hospital, Lille · Lille, NORD and 3 other locations · NCT05699005

• Comparing revascularization strategies for heart attack patients with cardiogenic shock

  This study is testing whether treating multiple blocked heart arteries right away helps heart attack patients in shock feel better compared to just fixing the main blockage.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT05527717

• Using a Pulmonary Artery Catheter to Improve Outcomes in Cardiogenic Shock

  This study is testing if using a special heart monitoring device early on can help people with severe heart failure feel better and survive their hospital stay.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT05485376

• Improving outcomes for patients with cardiogenic shock in Lower Silesia

  This study is trying to improve treatment for people in Lower Silesia who are experiencing cardiogenic shock by using a new system to decide who needs to be transferred to a specialized hospital for better care.

  Recruiting Wroclaw Medical University · Wroclaw · NCT05465200

• Understanding outcomes in patients with cardiogenic shock

  This study looks at how different treatments and support devices can help people with cardiogenic shock feel better and improve their chances of recovery.

  Recruiting Yonsei University · Seoul · NCT05415332

• Evaluating early implantation of a heart pump in patients with severe heart issues

  This study is testing if putting in a heart pump early can help people with severe heart problems from a heart attack feel better and live longer compared to just standard treatment.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille, Bouche DU Rhone · NCT05366452

• Repairing the mitral valve in patients with cardiogenic shock

  This study tests if a new heart procedure called TEER can help patients in cardiogenic shock with leaky mitral valves feel better compared to standard treatments.

  Recruiting at 2 sites Ottawa Heart Institute Research Corporation · Rochester, Minnesota and 3 other locations · NCT05298124

• Collaborative effort to improve care for patients with cardiogenic shock

  This study is trying to gather information on how to better care for patients with cardiogenic shock caused by heart problems to help improve their treatment and outcomes.

  Recruiting at 3 sites University of Utah · Weston, Florida and 2 other locations · NCT05185492

• Lowering blood pressure target to reduce noradrenaline use in cardiogenic shock patients

  This study is testing if aiming for a lower blood pressure target can help patients in cardiogenic shock use less medication and improve their chances of survival and kidney health.

  Recruiting Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT05168462

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

• Registry for patients with cardiogenic shock

  This study is gathering health information from patients with cardiogenic shock at different hospitals to help improve treatment and understanding of this serious condition.

  Recruiting at 16 sites Tufts Medical Center · Weston, Florida and 15 other locations · NCT04682483

• Monitoring heart function to prevent complications after cardiogenic shock

  This study tests if using a special device to monitor heart pressure can help people who have had cardiogenic shock recover better after their hospital stay.

  Recruiting Inova Health Care Services · Falls Church, Virginia · NCT04419480

• Analyzing outcomes of extracorporeal life support after cardiac surgery

  This study looks at how extracorporeal life support helps patients with heart failure after heart surgery to see what factors affect their chances of recovery.

  Recruiting University of Florence · Florence · NCT04330651

• Registry for patients with cardiogenic shock

  This study is collecting information on patients with cardiogenic shock in the hospital to better understand their causes and outcomes, so we can improve their care in the future.

  Recruiting Niguarda Hospital · Milan · NCT04295252

• Using VA-ECMO to treat cardiogenic shock in heart attack patients

  This study is testing if using a special heart support machine along with another device can help heart attack patients in severe shock feel better compared to just standard treatment.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04184635

• Registry of extracorporeal life support cases in China

  This study collects information on patients using extracorporeal life support (ECLS) in China to see how well it helps with heart and lung problems over time.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT04158479

• Registry for patients receiving ECMO or Impella devices

  This study is gathering information from patients who are receiving ECMO or Impella devices to see how well these treatments work for heart problems.

  Recruiting at 5 sites Insel Gruppe AG, University Hospital Bern · Basel and 4 other locations · NCT04117230

• Using levosimendan to treat cardiogenic shock

  This study is testing if giving levosimendan early can help adults with cardiogenic shock feel better and improve their chances of survival compared to a placebo.

  Recruiting at 24 sites Phase 3 Central Hospital, Nancy, France · Strasbourg, Bas-Rhin and 27 other locations · NCT04020263

• Registry for patients with cardiogenic shock at Inova Heart and Vascular Institute

  This study looks at how well a special team helps patients with cardiogenic shock, including those with severe heart failure or heart attacks, by comparing survival rates and treatments before and after the team was formed in 2017.

  Recruiting Inova Health Care Services · Falls Church, Virginia · NCT03378739

• Investigating treatment outcomes for patients with cardiogenic shock

  This study looks at how different treatments for cardiogenic shock work for patients to see which ones are most effective and what side effects they might have.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT03313687

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Predicting Risk and Treatment Effects in Cardiogenic Shock after Heart Attack

  This grant backs a patient-focused effort to use modern methods to understand how to best use life-saving devices in people who have a heart attack with severe heart pump failure.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11397533

• How ECMO affects the left side of the heart during severe cardiogenic shock

  This project looks at how veno-arterial ECMO (a heart–lung support machine) changes left-heart function in people with cardiogenic shock.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11142616

• Effects of ECMO support on heart function during severe heart failure

  This study is looking at how a special heart support machine called VA-ECMO helps people with severe heart failure, especially focusing on how it affects the heart's left ventricle, to better understand its benefits and any possible issues for patients in critical condition.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10898923

Related topics

Quick answers

How many Cardiogenic Shock clinical trials are recruiting right now?

72, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (15 trials), France (9 trials), Italy (9 trials), Germany (8 trials), South Korea (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 3, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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