Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis
Official title: Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention of Chronic Critical Illness after Sepsis
Funded at University of Florida · NIH-11399124 · Data updated 2026-11-12
Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $422,125 |
| NIH project number | 5R35GM160352-02 |
| Project ID | NIH-11399124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Surgical sepsis patients at risk of or currently experiencing chronic critical illness who are open to immune profiling and targeted interventions.
✕Less likely to help
Patients without sepsis or those not at risk for chronic critical illness are unlikely to benefit.
What this research studies
This project focuses on sepsis patients who suffer ongoing organ dysfunction and nutrition/immune problems. It aims to identify immune endotypes by studying specific immune cells and pathways, including myeloid-derived suppressor cells and DNA methylation patterns. The goal is to find personalized intervention strategies that could help prevent chronic critical illness and improve recovery after sepsis.
Why it matters
Potential benefit: If successful, patients who survive sepsis could recover more fully and regain function sooner through personalized immune-targeted therapies.
How similar studies have gone: Previous work shows immune profiling can reveal patient subgroups, but endotyping sepsis remains challenging and this project aims to refine approaches.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Cai, Guoshuai — University of Florida
- Study coordinator: Cai, Guoshuai
Related research
Other NIH-funded projects on the same topics.
-
Precision medicine in sepsis with critical illness
A patient-facing overview of a Stanford-led effort to tailor sepsis treatment by identifying subgroups of patients who may respond to specific therapies.
-
Understanding Chronic Critical Illness After Severe Injury or Infection
This work aims to better understand why some patients stay very sick for a long time after severe injuries or infections like sepsis.
-
Personalized Care for Sepsis and Critical Illness
This work aims to find different types of sepsis in patients to help doctors choose the best treatments for each person.
-
Understanding immune responses in patients with chronic critical illness after severe trauma or sepsis
This study is looking at how the immune system works in people who have survived serious injuries or infections and are dealing with ongoing health problems, like frequent infections and muscle weakness, to find better ways to help them feel better.
-
Understanding how different biological responses affect sepsis treatment
This study is looking at different ways sepsis affects people based on their immune responses, so we can find better treatments that fit each person's needs and improve care for those dealing with this serious condition.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.