Personalized Antibiotic Dosing for Critically Ill Patients
Official title: Antibiotic Model-Informed Precision Dosing in Critical Illness
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11124876 · Data updated 2026-11-12
This research aims to find the best way to give antibiotics to very sick patients, making sure they get the right amount for their individual needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $397,500 |
| NIH project number | 5R35GM146701-04 |
| Project ID | NIH-11124876 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is focused on adult patients who are critically ill and require antibiotic treatment.
✕Less likely to help
Patients who are not critically ill or do not require antibiotics would not directly benefit from this specific dosing approach.
What this research studies
When you are critically ill, your body can process medications differently, which means a standard antibiotic dose might not be effective or could even be harmful. This project seeks to develop a more personalized approach to antibiotic dosing, moving away from a "one-size-fits-all" method. By using real-time drug levels and individual patient information, we hope to ensure that critically ill patients receive the precise amount of antibiotics needed to fight infection effectively while avoiding side effects. This personalized dosing could lead to better treatment outcomes and safer care.
Why it matters
Potential benefit: If successful, this approach could lead to more effective antibiotic treatments and fewer side effects for critically ill patients, potentially improving their recovery and survival.
How similar studies have gone: While the current "one-size-fits-all" approach has shown risks, emerging data supports the need for personalized dosing, and model-informed precision dosing has shown promise in other areas of medicine.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Tang Girdwood, Sonya C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Tang Girdwood, Sonya C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.