Deciphering why some patients stay a long time in the ICU using detailed clinical profiling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, multi-center study enrolling adults (18+) with an ICU length of stay of five days or more to perform deep clinical phenotyping of persistent critical illness. Investigators will collect detailed data on organ support (mechanical ventilation, vasopressors), infections, medications (including corticosteroids and sedatives), mobility, delirium, laboratory results, and clinical outcomes. No experimental treatments are given; data are used to define clinical subgroups and link early risk factors to recovery trajectories. The study is conducted across several hospitals in the Lisbon district to capture real-world variability in care and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 years or older;
* ICU length of stay equal to or greater than 5 days.

Exclusion Criteria:

* Patients with an ICU stay \< 5 days;
* Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery;
* Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).

Where it's running

• Centro Hospitalar de São João / ULS São João
  Lisbon, Lisbon District, Portugal Recruiting
• Hospital de Vila Franca de Xira / ULS Estuário do Tejo
  Lisbon, Lisbon District, Portugal Recruiting
• Hospital Garcia de Orta / ULS Almada-Seixal
  Lisbon, Lisbon District, Portugal Recruiting
• Hospital Prof. Doutor Fernando Fonseca / ULS Amadora -Sintra
  Lisbon, Lisbon District, Portugal Recruiting
• Hospital Santa Maria / ULS Santa Maria
  Lisbon, Lisbon District, Portugal Recruiting
• Hospital São Francisco Xavier / Centro Hospitalar de Lisboa Ocidental
  Lisbon, Lisbon District, Portugal Recruiting

Study contacts

• Principal investigator: Susana Fernandes, MD PhD — Lisbon School of Medicine
• Study coordinator: Susana Fernandes, MD PhD.
• Email: susanamfernandes@medicina.ulisboa.pt
• Phone: 351 21 798 5100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.