Humidification methods in trauma ICU patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares two airway humidification methods in trauma ICU patients requiring extended mechanical ventilation. It examines how active heated humidification versus passive heat-and-moisture exchangers affect airway secretions, tube blockages, and clinical outcomes such as ventilator-associated pneumonia, duration of ventilation, and length of ICU stay. The study focuses on trauma patients who may have thick or bloody secretions that challenge airway management. Participants are adults aged 18–65 admitted to Assiut University Trauma ICUs, with prolonged ventilation anticipated (≥7 days). Exclusion criteria include immunosuppression, very low white blood cell counts, withdrawal of life support within 5 days, and specific contraindications to heat-and-moisture exchangers.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Adult age 18-65 years.
2. Trauma ICU patients receiving invasive mechanical ventilation.
3. Anticipated to require prolonged mechanical ventilation, defined as ≥7 days of invasive ventilatory support

Exclusion Criteria:

1. Immunosuppression such as HIV, cancer or AIDS.
2. Blood leukocyte count \<1,000 cells/mm3.
3. Withdrawal of life-sustaining treatment within 5 days.
4. Use of HME in conjunction with an HH.
5. Contraindications of HME including body temperature \< 32°C, copious, thick, or bloody secretions, significant air leak (exhaled VT \>70% of VT inspired) or broncopleural fistula

Where it's running

• Trauma Intensive Care Units, Assiut University Hospital
  Asyut, Asyut Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mostafa MA Ali, MSc Candidate
• Email: Mostafa1156@aun.edu.eg
• Phone: +201091423626

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.