Brain blood flow and brain regulation in critically ill kids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this observational study, researchers will use Transcranial Doppler to measure cerebral blood flow velocity in mechanically ventilated pediatric patients in the PICU. They aim to establish normal ranges, describe patterns across neurologic risk groups, and determine how cerebral autoregulation dysfunction relates to functional outcomes by comparing pre-illness status with discharge status. Enrollment targets 125 participants over a PICU stay of roughly 3–14 days, with data collected alongside arterial blood pressure monitoring. The results could help identify children at higher risk of neurological issues and lay the groundwork for autoregulation-guided hemodynamic management in pediatrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English
* Mechanically ventilated (Endotracheal tube)
* Indwelling arterial catheter
* Current patient in the American Family Children's Hospital PICU.
* 1 day to 17.5 years of age

Exclusion Criteria:

* Subjects with a known or obvious anatomic barrier preventing safe application of the transcranial Doppler probe (e.g., cranial dressings, cranial fixation hardware, ventricular access devices positioned over insonation sites, or bilateral craniectomies)
* Patient with known chronic hypertension
* Admission FSS score \> 16
* Tracheostomized patient
* The designated sub-investigator (Dr. Talal Al Hendawi) and PI (Dr. Neil Munjal) are unavailable to perform the Transcranial Doppler scan at the time of eligibility. All study scans are performed by either Dr. Al Hendawi or Dr.Munjal to ensure standardization and data integrity. Therefore, if they are unavailable (e.g., due to clinical service, leave, or other scheduling constraints), the patient will not be enrolled in the study.
* Not suitable for study participation due to other reasons at the discretion of the investigators

Where it's running

• American Family Children's Hospital PICU
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Neil Munjal, MD — UW School of Medicine and Public Health
• Study coordinator: Meg Baker
• Email: meg.baker@wisc.edu
• Phone: meg.baker@wisc.edu

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.