Single-beat TE-e' for estimating left atrial pressure in critically ill patients
Official title: The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU Trial
Run by Queen Mary Hospital, Hong Kong · NCT07820319 · Data updated 2026-11-12
A noninvasive test using a single-beat TE-e' echocardiography measurement is being tried to see if it can reliably indicate elevated left atrial pressure in critically ill adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Queen Mary Hospital, Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT07820319 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older in the Queen Mary Hospital ICU who require a transthoracic echocardiogram as part of routine care and where TE-e' can be measured by both methods.
✕Probably not a fit
Patients with atrial fibrillation, poor echocardiographic windows, or where TE-e' cannot be obtained or interpreted by either method may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares a new single-beat TE-e' echocardiography technique with the standard two-beat method to estimate left atrial pressure in critically ill adults. It uses transthoracic echocardiography performed as part of routine care in the adult ICU at Queen Mary Hospital, Hong Kong. Researchers will assess how well the single-beat TE-e' measurements correlate with the conventional approach and with clinically assessed LAP, using other echocardiographic parameters. The goal is to determine whether the faster single-beat method provides reliable information without invasive catheter-based pressure measurement.
Why it matters
Potential benefit: If successful, the single-beat TE-e' method could offer a quicker, noninvasive way to identify elevated left atrial pressure in critically ill patients.
How similar studies have gone: Previous work has explored TE-e' for diastolic assessment, but the single-beat approach is a novel variation; evidence of equivalence from prior studies is limited and ongoing.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients ≥18 years admitted to the QMH Adult Intensive Care Unit (AICU) * Requiring a transthoracic echocardiogram (TTE) as part of routine clinical care * TE-e' obtainable by both the conventional and the novel method Exclusion Criteria: * Patients \<18 years of age * Patients in atrial fibrillation * Patients with a poor TTE acoustic window * Patients in whom TE-e' is technically difficult to obtain or interpret by either method
Where it's running
-
Adult Intensive Care Unit, Queen Mary Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Study coordinator: Wincy Ng, MBBS
- Email: wincyngwingsze@gmail.com
- Phone: 22551331
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.