Precision medicine in sepsis with critical illness
Funded at Stanford University · NIH-11331391 · Data updated 2026-11-12
A patient-facing overview of a Stanford-led effort to tailor sepsis treatment by identifying subgroups of patients who may respond to specific therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2021 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $446,600 |
| NIH project number | 2R35GM142992-06 |
| Project ID | NIH-11331391 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis or critical illness who are candidates for targeted therapies based on their molecular and inflammatory profiles.
✕Less likely to help
Patients whose sepsis does not align with the identified biologically homogeneous subgroups or who are outside study timelines may see no direct benefit.
What this research studies
This project uses advanced data science to analyze detailed clinical and biological information from thousands of sepsis patients to find biologically similar subgroups. It aims to link these subgroups to potential treatments that could work better for each group, beyond standard antibiotics and supportive care. The work builds on prior findings of Hyperinflammatory and Hypoinflammatory phenotypes and looks for the key biological pathways that drive responses to therapies. By identifying who might benefit from targeted interventions, this research could guide more personalized care for septic patients in the future.
Why it matters
Potential benefit: If successful, patients with sepsis could receive more personalized treatments based on their biology, potentially improving survival and reducing complications.
How similar studies have gone: Prior work has shown reproducible sepsis subgroups with distinct biology and outcomes, guiding exploration of targeted treatments.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Sinha, Pratik — Stanford University
- Study coordinator: Sinha, Pratik
Related research
Other NIH-funded projects on the same topics.
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Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis
Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.
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Understanding Chronic Critical Illness After Severe Injury or Infection
This work aims to better understand why some patients stay very sick for a long time after severe injuries or infections like sepsis.
-
Personalized Care for Sepsis and Critical Illness
This work aims to find different types of sepsis in patients to help doctors choose the best treatments for each person.
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Understanding immune responses in patients with chronic critical illness after severe trauma or sepsis
This study is looking at how the immune system works in people who have survived serious injuries or infections and are dealing with ongoing health problems, like frequent infections and muscle weakness, to find better ways to help them feel better.
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Understanding how different biological responses affect sepsis treatment
This study is looking at different ways sepsis affects people based on their immune responses, so we can find better treatments that fit each person's needs and improve care for those dealing with this serious condition.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.