Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that records diaphragm surface electromyography (sEMG) using the SERA device, esophageal pressure (effort), and oxygen consumption in mechanically ventilated ICU patients during a spontaneous breathing trial (SBT). Measurements are taken while patients undergo an SBT as part of routine care; no experimental treatment is given. The main question is whether the sEMG signal, effort parameters, and oxygen consumption are associated with SBT failure or extubation failure within 48 hours, and whether these metrics improve on the rapid shallow breathing index (RSBI). Data will be analyzed to explore correlations between the signals and clinical weaning outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Esophageal catheter in situ (standard of care)
* Eligible for an SBT in the near future according to the LUMC SBT protocol currently valid

Exclusion Criteria:

* Severe cardiac failure NYHA class IV without mechanical support (LVAD or Impella)
* COPD Gold IV
* Pregnancy
* Patients with ECMO

Where it's running

• Leiden University Medical Centre
  Leiden, Netherlands Recruiting

Study contacts

• Study coordinator: Abraham Schoe, MD, PhD
• Email: a.schoe@lumc.nl
• Phone: +31715265018

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.