Understanding immune responses in patients with chronic critical illness after severe trauma or sepsis
Official title: Immunological Endotyping of Chronic Critical Illness after Severe Trauma or Sepsis
Funded at University of Washington · NIH-10892795 · Data updated 2026-11-12
This study is looking at how the immune system works in people who have survived serious injuries or infections and are dealing with ongoing health problems, like frequent infections and muscle weakness, to find better ways to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM142481-04 |
| Project ID | NIH-10892795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have survived severe trauma or sepsis and are currently experiencing chronic critical illness.
✕Less likely to help
Patients who have not experienced severe trauma or sepsis, or who do not have chronic critical illness, may not benefit from this research.
What this research studies
This research investigates how the immune system behaves in patients who have survived severe trauma or sepsis and are experiencing chronic critical illness. It focuses on identifying specific immune responses and patterns that contribute to ongoing health issues, such as recurrent infections and muscle weakness. By analyzing the immune profiles of these patients, the study aims to uncover the underlying mechanisms of their condition and improve treatment strategies. Patients may undergo assessments and provide samples to help researchers understand the relationship between their immune response and chronic illness.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and better outcomes for patients suffering from chronic critical illness following severe trauma or sepsis.
How similar studies have gone: Previous research has shown promise in understanding immune responses in critically ill patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Brakenridge, Scott Charles — University of Washington
- Study coordinator: Brakenridge, Scott Charles
Related research
Other NIH-funded projects on the same topics.
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Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention for Chronic Critical Illness after Sepsis
Aimed at people who have survived sepsis after surgery, this grant seeks to understand why some patients develop long-term organ problems and how to tailor treatments to their immune responses.
-
Precision medicine in sepsis with critical illness
A patient-facing overview of a Stanford-led effort to tailor sepsis treatment by identifying subgroups of patients who may respond to specific therapies.
-
Understanding Chronic Critical Illness After Severe Injury or Infection
This work aims to better understand why some patients stay very sick for a long time after severe injuries or infections like sepsis.
-
Personalized Care for Sepsis and Critical Illness
This work aims to find different types of sepsis in patients to help doctors choose the best treatments for each person.
-
Understanding how different biological responses affect sepsis treatment
This study is looking at different ways sepsis affects people based on their immune responses, so we can find better treatments that fit each person's needs and improve care for those dealing with this serious condition.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.