Bedside EIT-guided respiratory physiotherapy for adults on long-term ventilators

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized controlled trial will randomize adults who have received invasive mechanical ventilation for at least 21 consecutive days to either respiratory physiotherapy guided by real-time electrical impedance tomography (EIT) or to standardized conventional respiratory physiotherapy, with both groups receiving standard ICU care. Respiratory physiotherapy includes airway clearance, chest physiotherapy, breathing pattern optimization, and therapeutic positioning delivered with comparable frequency and duration between groups. In the EIT-guided arm, clinicians will use predefined ventilation distribution indicators on real-time EIT images to individualize physiotherapy maneuvers during each session. The primary outcome is ventilator-free days at day 28, with secondary outcomes including successful liberation from invasive ventilation and diaphragm ultrasound measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Invasive mechanical ventilation for ≥ 21 consecutive days.
* Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.
* Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.
* Written informed consent obtained from the patient or legally authorized representative.

Exclusion Criteria:

* Contraindications to electrical impedance tomography .
* Hemodynamic instability requiring high-dose vasoactive support.
* Severe hypoxemia refractory to optimization.
* Unstable fractures or other contraindications to mobilization or positioning.
* Pregnancy.
* Expected death within 48 hours.

Where it's running

• Beijing Rehabilitation Hospital Affiliated to Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yi Li
• Email: liyi_bjkfyy@126.com
• Phone: 86 13810913780

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.