Reversing muscle paralysis in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of different reversal agents for neuromuscular blockade in critically ill patients who have undergone endotracheal intubation. Participants will be randomly assigned to receive either sugammadex, neostigmine, or no medication, and the time taken for neurological assessment will be measured. The study will monitor the Glasgow Coma Scale (GCS) and other neurological indicators to determine the impact of these agents on recovery time. The goal is to identify which agent, if any, facilitates quicker neurological recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.

Exclusion Criteria:

* Patients younger than 19 years of age
* Patients who are not neurologically evaluable or have concomitant neurologic dysfunction
* Patients with neuromuscular disorder
* Patients with a history of drug allergic reactions to sugammadex or neostigmine
* Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives

Where it's running

• Seoul National University Hospital
  Seoul, Jongno-gu, South Korea Recruiting

Study contacts

• Study coordinator: Leerang Lim, MD
• Email: erange@snu.ac.kr
• Phone: +82-10-5063-1742

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.