Using magnesium to prevent new atrial fibrillation in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, multi-centre, randomized, placebo-controlled feasibility pilot trial aimed at preventing new onset atrial fibrillation (NOAF) in critically ill patients admitted to an ICU. The study will compare the effects of parenteral magnesium sulfate against a placebo to assess its feasibility in reducing the incidence of NOAF. By focusing on prevention rather than treatment, this innovative approach seeks to improve patient outcomes and provide a cost-effective prophylactic option. The primary goal is to determine the feasibility of conducting a larger randomized controlled trial based on the initial findings.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Age ≥18 years;
2. Admitted to an ICU with one or more of the following:

   1. Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic)
   2. Vasopressor or inotropic support with an expected duration of \>24 hours
   3. Cardiac arrest
3. Continuous cardiac monitoring.

Exclusion Criteria

1. Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
2. Receiving IMV for airway protection only (for example, isolated head trauma)
3. Active atrial fibrillation at the time of enrolment
4. On oral or continuous infusion of Amiodarone
5. Unlikely to survive \>24 hours or palliative patients
6. Cardiac surgery patients
7. Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
8. Patients receiving dialysis
9. Positive pregnancy test (females \<50 years old)
10. Previously enrolled in this trial
11. Treating physician refuses enrollment

Where it's running

• Kingston Health Sciences Centre
  Kingston, Ontario, Canada Recruiting
• St Joseph's Healthcare Hamilton
  Hamilton, Ontario, Canada Not yet recruiting
• The Ottawa Hospital - General Campus
  Ottawa, Ontario, Canada Not yet recruiting
• The Ottawa Hospital - Civic Campus
  Ottawa, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Stephanie Sibley, MD — Queen's University
• Study coordinator: Miranda Hunt
• Email: miranda.hunt@kingstonhsc.ca
• Phone: 613 549 6666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.