How depth of anesthesia with BIS affects heart rate and blood pressure during emergency RSI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study examines hemodynamic responses during rapid sequence intubation in adult emergency department patients after confirming adequate anesthesia depth with BIS monitoring. Heart rate and blood pressure are captured before induction, during intubation, and after successful endotracheal intubation to assess changes under controlled anesthetic depth. The study uses BIS monitoring to ensure a BIS value of 45-55 prior to laryngoscopy, aiming to improve interpretation of hemodynamic responses. Eligible participants are adults 18 years or older undergoing RSI in the ED with BIS monitorable and no contraindications. Data will be collected at a single center, Akdeniz University Hospital, to characterize the relationship between anesthetic depth and hemodynamic changes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18 years or older. Patients undergoing rapid sequence intubation (RSI) in the emergency department.

Patients in whom bispectral index (BIS) monitoring can be applied before laryngoscopy.

Patients achieving an adequate depth of anesthesia (BIS 45-55) before laryngoscopy.

Written informed consent obtained from the patient or a legally authorized representative, when applicable according to local ethics requirements.

Exclusion Criteria:

Age \<18 years. Cardiac arrest before or during induction. Patients requiring immediate ("crash") intubation without sufficient time for BIS monitoring.

Inability to obtain reliable BIS monitoring (e.g., technical failure or inability to place the sensor).

Pregnancy. Facial or scalp conditions preventing BIS sensor placement. Prisoners or other vulnerable populations if excluded by the ethics protocol.

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Where it's running

• Akdeniz University Hospital
  Antalya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Erkan Göksu, MD
• Email: erkangoksu@akdeniz.edu.tr
• Phone: +905054691764

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.