Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes the relationship between vasopressor dose and gastric emptying in ICU patients receiving enteral nutrition. Gastric emptying is measured by bedside ultrasound at baseline, 1 hour, and 2 hours after restarting feeding following a brief fast. Participants are grouped by norepinephrine equivalent dose to see if higher vasopressor exposure is associated with poorer gastric motility. The primary outcome is the gastric emptying rate, with gastroparesis defined as a gastric emptying rate of zero or less per hour. All ultrasounds are performed by a blinded ICU fellow to ensure objective assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Admitted to the intensive care unit
* Receiving enteral nutrition via nasogastric or orogastric tube
* At least 4 hours of uninterrupted enteral nutrition prior to measurement
* At least 50% of daily caloric target achieved
* No change in feeding rate in the last 2 hours
* Written informed consent obtained from patient or legal representative

Exclusion Criteria:

* Age under 18 years
* History of gastrectomy or upper gastrointestinal surgery
* Known gastroparesis or diabetic gastropathy
* Active gastrointestinal bleeding
* Suspected bowel obstruction or perforation
* Prokinetic agent use within the last 24 hours
* BMI greater than 35 kg/m²
* Pregnancy
* Prone positioning more than 4 hours per day
* Intra-abdominal pressure greater than 15 mmHg
* Inadequate epigastric ultrasound window
* Jejunostomy, gastrostomy, or post-pyloric feeding tube
* Refusal of informed consent

Where it's running

• Basaksehir Cam ve Sakura City Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Rezan Şerefoğlu, M.D.
• Email: rezzan.ozcalimli@gmail.com
• Phone: +90 212 909 6000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.