Using Azithromycin to treat critical asthma in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CR-AZI Study investigates the effects of Azithromycin, a macrolide antibiotic, on the immune response in pediatric patients suffering from critical asthma. This interventional study will assess children aged 3-17 years who are hospitalized in the PICU with a primary diagnosis of critical asthma and are receiving standard treatments like inhaled or intravenous beta-agonists and systemic corticosteroids. The researchers aim to measure levels of a specific inflammatory biomarker, periostin, to determine if Azithromycin can lower these levels compared to those not receiving the drug. Additionally, the study will evaluate the safety of Azithromycin by monitoring adverse events and examining clinical efficacy markers.

Why it matters

Who can join: the full rules

Inclusion criteria

* Age 3-17 years
* Admission to the PICU
* Primary diagnosis of critical asthma
* Prescription for continuous inhaled beta-agonist therapy and/or intravenous (IV) beta-agonist therapy
* Prescription for intravenous systemic corticosteroids

Exclusion criteria

* Critical Congenital Heart Disease Unrepaired
* Tracheostomy Dependence at Admission
* Ongoing Exposure to Azithromycin or Macrolide Antibiotics for any indication
* Past Medical History of Prolonged QT Syndrome or Arrhythmias
* Concomitant respiratory pathology including Acute Chest Syndrome, Interstitial Lung Disease, Cystic Fibrosis, and pulmonary hypertension

Where it's running

• Johns Hopkins All Children's Hospital
  St. Petersburg, Florida, United States Recruiting

Study contacts

• Principal investigator: Anthony A Sochet, MD — Johns Hopkins All Children's Hospital
• Study coordinator: Anthony A Sochet, MD
• Email: Sochet@jhmi.edu
• Phone: 727-487-3711

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.