Magnesium replacement targets for people in the ICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multi-center, open-label, randomized trial embedded in the shared electronic medical record at participating hospitals in Ontario, comparing a higher magnesium replacement target (>0.95 mmol/L) to a lower target (>0.7 mmol/L) for adults admitted to medical-surgical ICUs. Patients aged 16 and older who have an order for the magnesium replacement protocol are randomized to one of the two target strategies and receive magnesium supplementation per the assigned protocol. The primary outcome is an ordinal composite at 30 days combining death and the number of ICU days free of atrial fibrillation or flutter; secondary outcomes include ventricular arrhythmia, use of antiarrhythmics, vasopressor and ventilator use, new renal replacement therapy, lengths of stay, and magnesium dosing and levels. Analyses use an intention-to-treat approach with Bayesian regression and weakly skeptical priors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 16 years or older
* Admission orders written to a medical-surgical intensive care unit at a participating site
* Magnesium replacement protocol ordered

Exclusion Criteria:

* Prior enrollment in or withdrawal from MAGNOLIA trial
* Sustained ventricular tachycardia
* Pre-eclampsia
* Myasthenia gravis

Where it's running

• Lakeridge Health Ajax-Pickering
  Ajax, Ontario, Canada Recruiting
• Lakeridge Health Bowmanville
  Bowmanville, Ontario, Canada Recruiting
• Lakeridge Health Oshawa
  Oshawa, Ontario, Canada Recruiting
• Scarborough Centenary Hospital
  Toronto, Ontario, Canada Recruiting
• Scarborough General Hospital
  Toronto, Ontario, Canada Recruiting
• Scarborough Birchmount Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Joshua Craig
• Email: jcraig@shn.ca
• Phone: 4164382911

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.