Effects of High-Frequency Oscillatory Ventilation in ICU Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the safety and efficacy of Continuous High-Frequency Oscillatory Ventilation (CHFO) in awake ICU patients suffering from atelectasis. The study aims to assess pulmonary function by comparing chest electrical impedance tomography (EIT) measurements before and after CHFO treatment. A minimum of 45 patients will be enrolled, and their vital signs and subjective comfort ratings will be collected throughout the treatment process. The goal is to determine the impact of CHFO on lung function and patient comfort in a critical care setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients older than 18 and younger than 90 years;
* Admitted to the ICU after December 1, 2024, who are alert, with a GCS of 15, normal comprehension, and able to communicate clearly through speech or writing.
* Patients with atelectasis, who are receiving oxygen therapy, high-flow oxygen, or are on a ventilator via tracheostomy.
* Signed informed consent for MetaNeb treatment.

Exclusion Criteria:

* Refusal to participate in the proposed study.
* Age \< 10 years;
* Pregnancy;
* Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.
* Participation in another trial within 30 days prior to meeting eligibility criteria;
* Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;
* Pneumothorax. With a clear tracheoesophageal fistula

Where it's running

• Zhongshan Hospital, Fudan University
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Shengyu Hao, PhD
• Email: janet9yu@163.com
• Phone: 02164041990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.