Investigating how mitochondrial dysfunction affects recovery after critical illness
The Role of Mitochondrial Dysfunction in Physical Recovery after Critical Illness
This study is looking at how problems with energy production in your muscles might affect the recovery of veterans who have survived serious illnesses, and it hopes to find ways to improve their rehabilitation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11041032 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial dysfunction in the physical recovery of patients who have survived critical illness, particularly veterans. It aims to explore how impairments in energy generation within skeletal muscles can lead to long-term physical function issues. By enrolling 62 veterans who have experienced critical illness, the study will measure mitochondrial oxidative capacity and its relationship to physical recovery. The findings could help develop more effective rehabilitation interventions for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have survived a stay in the intensive care unit and are experiencing difficulties in physical recovery.
Not a fit: Patients who have not experienced critical illness or those with pre-existing severe physical disabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation strategies that enhance physical recovery for critically ill patients.
How similar studies have performed: While there have been studies on rehabilitation after critical illness, this specific focus on mitochondrial dysfunction and its impact on recovery is relatively novel.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Mart, Matthew Franklin — Veterans Health Administration
- Study coordinator: Mart, Matthew Franklin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.