Immunological and inflammation markers linked to ICU patient outcomes
Official title: Studies on the Immunological and Inflammatory Determinants Associated With the Prognosis of Patients Admitted to Intensive Care
Run by Assistance Publique - Hôpitaux de Paris · NCT07345169 · Data updated 2026-11-12
This study will try to see if certain immune and inflammation markers taken from adults admitted to intensive care can predict one-year survival and the risk of hospital-acquired infections.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 540 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | February 2031 |
| Study ends | February 2031 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT07345169 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older who are admitted to the ICU within 24 hours and do not have pre-existing immunosuppression, pregnancy, legal protection status, or participation in another interventional trial.
✕Probably not a fit
Patients unlikely to benefit include those with active or recent immunosuppression, moribund patients, uninsured individuals, pregnant or breastfeeding women, and people under guardianship or curatorship, who are excluded from the protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study enrolling adults admitted to the ICU within 24 hours to collect routine and minimal extra blood samples for immune and inflammatory biomarker analysis. Samples are taken at admission, day 1, day 4, day 8, at ICU discharge or day 28, and again at 12 months, with additional sampling during major clinical events such as nosocomial infections. The data will be used to build multidimensional models predicting one-year survival and the occurrence of hospital-acquired infections. Patients with pre-existing immunosuppression, pregnant or breastfeeding women, moribund patients, uninsured people, and those under legal protection are excluded.
Why it matters
Potential benefit: If successful, the results could help clinicians identify ICU patients at higher risk of death or infection earlier so care and monitoring can be tailored.
How similar studies have gone: Previous observational work has linked immune and inflammatory markers to outcomes in sepsis and critical illness, but predictive models remain variable and this study seeks to improve them with longitudinal sampling.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Admission to ICU within 24 hours Exclusion Criteria: * Moribund patient (ECOG=4) * Legal protection (guardianship/curatorship) * Uninsured patients * Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV) * Pregnant or breastfeeding women * Participation in another interventional trial * Patients under AME
Where it's running
-
AP-HP Laribosière Hospital, Anesthesia and Critical Care Departement
Paris, France Recruiting
Study contacts
- Study coordinator: Charles de de Roquetaillade, MD
- Email: charles.de-roquetaillade@aphp.fr
- Phone: +33 1 49 95 85 15
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.