Endogenous energy production in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will study how endogenous energy substrates are produced in ICU patients during fasting and while receiving nutrition, using tracer dyes to track glucose, glycerol, and amino acids. The study is done in two or more time points early and later in the ICU to see if and when the body shifts from non-suppressible catabolism to a normal anabolic response to nutrition. Blood samples will also be analyzed to find biomarkers that indicate an anabolic response. The protocol includes careful monitoring of blood glucose and stopping nutrition infusions if hypoglycemia occurs. This work aims to better understand metabolic timing in critical illness and potentially guide feeding strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For the ICU group:

1. ≥18 years old and admitted to the ICU
2. Invasive mechanical ventilation
3. Arterial and central line in situ
4. Expected to remain in ICU \>72 hours

For the control group:

1\. ≥18 years old

Exclusion Criteria:

1. Lack of informed consent by patient/next of kin
2. Liver transplant
3. Acute or acute on chronic liver failure
4. Cirrhosis
5. Known diabetes mellitus
6. Pancreatic surgery
7. Acute or chronic pancreatitis
8. Pregnancy
9. Intubated only for airway protection or neurologic deficit
10. Mitochondrial disease
11. Disorder of amino acid metabolism
12. Familial hypertriglyceridemia
13. Severe acquired hypertriglyceridemia (≥10 mmol/L)
14. Requiring treatment of hypoglycemia in the last 72 hours before inclusion.
15. Requiring ongoing large volume resuscitation of crystalloids or blood products
16. \>72 hours in ICU before enrollment
17. Readmission to ICU within 1 week of ICU discharge.
18. Morbidly obese (BMI ≥35)
19. Limitations of treatment to best supportive care
20. Ongoing treatment with insulin/glucose related to hyperkalemia

Where it's running

• Karolinska University Hospital Huddinge
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Martin Sundström Rehal, MD PhD — Karolinska University Hospital/Karolinska Institute
• Study coordinator: Martin Sundström Rehal, MD PhD
• Email: martin.sundstrom-rehal@regionstockholm.se
• Phone: +46812381507

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.