Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients
Official title: High-flow Nasal Oxygenation for Apnoeic Oxygenation With Optiflow Switch During Intubation of the Critically Ill Adult- a Prospective Before-and-after Study
Run by Region Stockholm · NCT05883137 · Data updated 2026-11-12
This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Stockholm, Stockholm County) |
| Status | Recruiting |
| Started | September 25, 2023 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | April 11, 2025 |
| Trial ID | NCT05883137 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients in intensive care who require tracheal intubation.
✕Probably not a fit
Patients with skull or facial injuries, total nasal obstruction, or those deemed unsuitable for other reasons will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of High Flow Nasal Oxygen (HFNO) using the Optiflow Switch during tracheal intubation in critically ill patients. It compares traditional preoxygenation methods with the addition of HFNO to determine if it reduces the risk of hypoxaemia and other adverse events during intubation. The study will involve a before-and-after design, including a minimum of 50 patients over a period of 6-12 months. Patient characteristics and vital parameters will be monitored before, during, and after the intubation process.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of hypoxaemia during intubation in critically ill patients.
How similar studies have gone: Previous studies have shown mixed results regarding the use of HFNO during intubation, making this approach both relevant and potentially novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult, ≥18 years old * Intensive care patients that require tracheal intubation for any indication Exclusion Criteria: * Patients with skull or facial injuries where the application of nasal cannula is to be avoided, decided by the intensivist. * Pregnancy * Total nasal obstruction * Deemed not suitable for any other reason than the aforementioned
Where it's running
-
Karolinska University Hospital
Stockholm, Stockholm County, Sweden Recruiting
Study contacts
- Study coordinator: Ida-Maria Forsberg, PhD
- Email: ida-maria.forsberg@regionstockholm.se
- Phone: + 46704381445
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Brain blood flow and brain regulation in critically ill kids
This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.
-
Ciprofol versus propofol for sedating adult ICU patients on noninvasive respiratory support
See if ciprofol works better than propofol for sedating adults in the ICU who are receiving noninvasive ventilation, high-flow nasal cannula, or oxygen therapy.
-
Bedside EIT-guided respiratory physiotherapy for adults on long-term ventilators
This trial will test whether using bedside electrical impedance tomography to guide respiratory physiotherapy helps adults who have been on a ventilator for 21 days or more get more days off the ventilator within the first 28 days.
-
Real-time, algorithm-driven ventilation feedback to improve lung protection in ARDS
This study tests whether a cloud-based, real-time ventilation feedback system helps doctors deliver more lung-protective ventilation to adults with ARDS on invasive mechanical ventilation.
-
Combining chest X-rays and arterial blood gas results to predict ventilator need in critically ill adults
This project will test whether a computer model that uses chest X-rays and arterial blood gas results can predict which critically ill adults will need mechanical ventilation.
-
Effects of High-Frequency Oscillatory Ventilation in ICU Patients
This study is testing whether a new breathing treatment called Continuous High-Frequency Oscillatory Ventilation can improve lung function and comfort for awake ICU patients with collapsed lungs.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.