Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients
High-flow Nasal Oxygenation for Apnoeic Oxygenation With Optiflow Switch During Intubation of the Critically Ill Adult- a Prospective Before-and-after Study
This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Stockholm, Stockholm County) |
| Trial ID | NCT05883137 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of High Flow Nasal Oxygen (HFNO) using the Optiflow Switch during tracheal intubation in critically ill patients. It compares traditional preoxygenation methods with the addition of HFNO to determine if it reduces the risk of hypoxaemia and other adverse events during intubation. The study will involve a before-and-after design, including a minimum of 50 patients over a period of 6-12 months. Patient characteristics and vital parameters will be monitored before, during, and after the intubation process.
Who should consider this trial
Good fit: Ideal candidates are adult patients in intensive care who require tracheal intubation.
Not a fit: Patients with skull or facial injuries, total nasal obstruction, or those deemed unsuitable for other reasons will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of hypoxaemia during intubation in critically ill patients.
How similar studies have performed: Previous studies have shown mixed results regarding the use of HFNO during intubation, making this approach both relevant and potentially novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult, ≥18 years old * Intensive care patients that require tracheal intubation for any indication Exclusion Criteria: * Patients with skull or facial injuries where the application of nasal cannula is to be avoided, decided by the intensivist. * Pregnancy * Total nasal obstruction * Deemed not suitable for any other reason than the aforementioned
Where this trial is running
Stockholm, Stockholm County
- Karolinska University Hospital — Stockholm, Stockholm County, Sweden (Recruiting)
Study contacts
- Study coordinator: Ida-Maria Forsberg, PhD
- Email: ida-maria.forsberg@regionstockholm.se
- Phone: + 46704381445
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.