Clinical trial Recruiting at 1 site Observational Ages 18 to 100

Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients

Official title: High-flow Nasal Oxygenation for Apnoeic Oxygenation With Optiflow Switch During Intubation of the Critically Ill Adult- a Prospective Before-and-after Study

Run by Region Stockholm · NCT05883137 · Data updated 2026-11-12

This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment150 (estimated)
SponsorRegion Stockholm
Government
Locations1 site (Stockholm, Stockholm County)
StatusRecruiting
StartedSeptember 25, 2023
Main results expectedJune 30, 2026
Study endsJune 30, 2026
Registry record updatedApril 11, 2025
Trial IDNCT05883137 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult patients in intensive care who require tracheal intubation.

Probably not a fit

Patients with skull or facial injuries, total nasal obstruction, or those deemed unsuitable for other reasons will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of High Flow Nasal Oxygen (HFNO) using the Optiflow Switch during tracheal intubation in critically ill patients. It compares traditional preoxygenation methods with the addition of HFNO to determine if it reduces the risk of hypoxaemia and other adverse events during intubation. The study will involve a before-and-after design, including a minimum of 50 patients over a period of 6-12 months. Patient characteristics and vital parameters will be monitored before, during, and after the intubation process.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of hypoxaemia during intubation in critically ill patients.

How similar studies have gone: Previous studies have shown mixed results regarding the use of HFNO during intubation, making this approach both relevant and potentially novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult, ≥18 years old
* Intensive care patients that require tracheal intubation for any indication

Exclusion Criteria:

* Patients with skull or facial injuries where the application of nasal cannula is to be avoided, decided by the intensivist.
* Pregnancy
* Total nasal obstruction
* Deemed not suitable for any other reason than the aforementioned

Where it's running

  • Karolinska University Hospital
    Stockholm, Stockholm County, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.