Condition

Mechanical Ventilation clinical trials and research

• 72Clinical trials
• 23NIH research projects
• 6New in 30 days
• 28Countries

Newest Mechanical Ventilation clinical trials

All recruiting trials (72)

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery

  In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.

  Recruiting Hopital Charles Nicolle · Tunis · NCT07885124

• Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults

  This study tests how different patient breathing efforts relate to breathlessness in adults on assisted mechanical ventilation.

  Recruiting University of Crete · Heraklion · NCT07877350

• FCV vs VC—Obese Adults Undergoing Laparoscopic Surgery

  In obese adults having laparoscopic surgery, researchers will see if flow-controlled ventilation (FCV) works better than volume-controlled ventilation with autoflow (VC-AF) at keeping airway pressures and lung energy lower.

  Recruiting Kocaeli University · Kocaeli, Izmit · NCT07875530

• Permissive lung-protective ventilation in invasively ventilated adults

  This study tests whether lowering the breathing rate during mechanical ventilation is better than standard lung-protective ventilation for adults in the ICU who need invasive ventilation.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, NL and 1 other locations · NCT07837128

• Titrating pressure support using the Flow Index in adults on mechanical ventilation

  This pilot trial tests whether using the Flow Index to guide PS titration in adults on invasive ventilation is feasible and helpful compared with standard methods.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT07769307

• Brain monitoring during ventilator therapy in critically ill patients

  This study tests how lung-directed ventilator adjustments affect brain activity and blood flow in adults with acute brain injury who need mechanical ventilation.

  Recruiting Shengli Oilfield Hospital · Dongying, Shandong · NCT07716787

• Heart rate variability feedback to help practitioners make better patient decisions

  This study tests whether giving healthcare workers HRV feedback during care improves how quickly and safely they respond to ventilator events and bedside needs.

  Recruiting Papworth Hospital NHS Foundation Trust · Cambridge, Cambridgeshire · NCT07709364

• How different ventilator settings affect lung energy during gallbladder surgery

  This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Yenimahalle, Ankara · NCT07670494

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• Understanding how often and why a patient’s breathing and the ventilator don’t stay in sync

  This study tests how often patient-ventilator asynchrony occurs in mechanically ventilated adults and how it relates to their health and outcomes.

  Recruiting at 2 sites Erasmus Medical Center · Eindhoven, North Brabant and 2 other locations · NCT07624786

• Right heart function after cardiac surgery: does respiratory acidosis matter?

  This study looks at whether respiratory acidosis after heart surgery affects how well the right side of the heart works in ICU patients.

  Recruiting Laval University · Québec, Quebec · NCT07619274

• Flow-Controlled vs Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery

  This trial tests whether flow-controlled ventilation works differently from volume-controlled ventilation during lumbar disc herniation surgery to see if it affects airway pressures and oxygen levels.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07614555

• Bedside bronchoscopy to clear airways in adults on ventilation with atelectasis

  This trial tests whether using bedside flexible bronchoscopy to clear airways helps improve lung aeration in intubated adults with atelectasis and lots of airway secretions.

  Recruiting Southeast University, China · Nanjing, Jiangsu · NCT07594379

• Skin conductance monitoring for premature infants on ventilators.

  We will try tiny electrodes on a premature baby's foot to see if changes in skin conductance reflect pain from different ventilator settings and whether skin-to-skin care lowers that stress.

  Recruiting Uppsala University Hospital · Uppsala, Uppland · NCT07568418

• Ventilation settings and acid-base balance after cardiac arrest or cardiogenic shock

  This study tests how different initial ventilator settings align with a decision-support algorithm to see if acid-base imbalances can be reduced in adults with cardiac arrest or cardiogenic shock on mechanical ventilation.

  Recruiting Laval University · Québec, Quebec · NCT07484828

• PEEP levels and breathing effort during assisted mechanical ventilation

  This trial tests whether changing PEEP levels can reduce excessive breathing effort in adults receiving assisted mechanical ventilation in the ICU.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07437846

• Flow-controlled versus volume-controlled ventilation during bariatric surgery

  This trial will see if flow-controlled ventilation or volume-controlled ventilation gives better oxygen levels and lower airway pressures during bariatric surgery in adults with obesity.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07430111

• How short high-oxygen exposures affect brain blood flow during mechanical ventilation

  We will test whether brief, controlled increases in ventilator oxygen change brain blood flow in adults who are intubated and on mechanical ventilation in the ICU.

  Recruiting Erasme University Hospital · Brussels · NCT07377162

• Recruitment maneuver after suction to restore lung volume in ventilated ICU patients

  This trial will test whether briefly raising airway pressure right after endotracheal suctioning helps reopen lungs and restore lung volume in adults on mechanical ventilation.

  Recruiting Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Toulon, VAR · NCT07358039

• Using extra intraoperative monitoring during major abdominal cancer operations to reduce time on a ventilator

  This study will test whether adding multimodal monitors during elective major abdominal cancer surgery can help patients aged 50 and older spend less time on mechanical ventilation.

  Recruiting University Hospital Dubrava · Zagreb, Croatia · NCT07339449

• Amnioinfusion to Protect Newborns After Meconium in Amniotic Fluid

  This trial tests whether a structured lactated Ringer's amnioinfusion during labor can reduce breathing problems and related complications in babies whose amniotic fluid contains meconium.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07274527

• Amino acid infusion after heart surgery to protect kids’ kidneys

  This study tests whether giving an amino acid infusion during and after pediatric heart surgery can lower the chance of acute kidney injury and reduce time on a ventilator, compared with a placebo.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07212595

• Measuring breathing drive and effort at different pressure support levels after major abdominal surgery

  This project will test whether changing pressure support levels can reveal under- or over-assistance of breathing in adults on ventilators after major abdominal surgery.

  Recruiting Mahidol University · Bangkok, Bangkoknoi · NCT07199881

• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

  This trial tests whether a personalized lung volume optimization maneuver using PEEP titration can improve heart and lung function in children after cardiopulmonary bypass surgery or in those with severe respiratory failure at risk for ECMO.

  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• Neuromuscular electrical stimulation for patients on invasive mechanical ventilation (MOVCARE)

  We will test whether adding neuromuscular electrical stimulation to usual physical therapy helps adults on invasive mechanical ventilation regain leg muscle strength faster.

  Recruiting Hospital Moinhos de Vento · Porto Alegre, Rio Grande do Sul · NCT07188350

• AbClo abdominal binder's effects on breathing mechanics in ventilated patients with an open abdomen

  This test will see if adjusting the AbClo abdominal binder changes lung pressures, lung volume, and breathing function in adults on ventilators with an open abdomen.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT07154589

• Pressure-support versus T-piece breathing test for overweight and obese adults on ventilators

  This test will see if a one-hour pressure-support or T-piece breathing trial helps overweight and obese adults on a ventilator be successfully extubated without needing reintubation within 72 hours.

  Recruiting Taipei Medical University Hospital · Taipei · NCT07114289

• Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

  We will see if surface diaphragm EMG, esophageal pressure, and oxygen use measured during a spontaneous breathing trial can predict who will fail to wean from the ventilator in the ICU.

  Recruiting Leiden University Medical Center · Leiden · NCT07109570

• Using levosimendan to shorten time on a ventilator

  This will test whether giving levosimendan to adults in the ICU who have failed a breathing trial helps them get off the ventilator sooner.

  Recruiting at 6 sites Phase 4 Radboud University Medical Center · Arnhem, Gelderland and 7 other locations · NCT07105202

• Respiratory acidosis during one-lung ventilation and how clinician settings compare with the VentilO app

  This project will try to see if ventilator settings chosen by clinicians or settings suggested by the VentilO smartphone app better prevent respiratory acidosis in adults having one-lung ventilation for thoracic surgery.

  Recruiting Laval University · Québec, Quebec · NCT07099963

• ICU rehabilitation for adults on invasive mechanical ventilation

  This project will look at rehabilitation approaches used in ICUs worldwide to see if they relate to outcomes for adults who have been on invasive mechanical ventilation for at least 48 hours.

  Recruiting Universita degli Studi di Genova · Genova, Italy · NCT07093125

• Driving-pressure guided ventilation versus lung-protective ventilation during elective laparoscopic surgery

  We will test if adjusting the ventilator to keep the driving pressure under 15 cm H2O helps adults having elective laparoscopic surgery breathe better while under general anesthesia.

  Recruiting Rawalpindi Medical College · Rawalpindi, Punjab Province · NCT07092943

• Permissive lung-protective ventilation for adults on invasive ventilators

  This tests whether using a lower breathing rate on the ventilator (allowing higher CO2) is safe and workable for adults in the ICU who are invasively ventilated for acute low oxygen levels.

  Recruiting at 5 sites Reinier de Graaf Groep · Almelo and 4 other locations · NCT07077174

• Doxapram to improve diaphragm movement during spontaneous breathing trials in ventilated COPD patients

  This trial will test whether giving IV doxapram helps the diaphragm move more in people with moderate to severe COPD who are on a ventilator and doing a spontaneous breathing trial.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07022704

• Combining chest X-rays and arterial blood gas results to predict ventilator need in critically ill adults

  This project will test whether a computer model that uses chest X-rays and arterial blood gas results can predict which critically ill adults will need mechanical ventilation.

  Recruiting Zagazig University · Zagazig, Al Sharqia · NCT07001696

• Improving pain control for children on breathing machines

  This trial tests whether giving IV acetaminophen and/or IV ketorolac can reduce pain and the need for opioids in children aged 2 months to 17½ years who are on mechanical ventilation for acute respiratory failure.

  Recruiting at 15 sites Phase 3 Weill Medical College of Cornell University · Little Rock, Arkansas and 15 other locations · NCT06994442

• Comparing two ventilation modes for ICU patients

  This study is trying to see which breathing support method, SIMV or MMV, works better for stable adult ICU patients by switching them between the two and monitoring their lung function.

  Recruiting Harran University · Sanliurfa · NCT06961227

• Effect of expiratory time constant (RCexp) on lung ventilation and blood flow in ventilated ARDS patients

  This tests whether the expiratory time constant (RCexp) changes how air and blood are distributed in the lungs of adults with ARDS who are on mechanical ventilation.

  Recruiting Southeast University, China · Nanjing, Jiangsu · NCT06919484

• Examining how muscle loss affects disease progression

  This study is trying to see how muscle loss affects the health and recovery of patients with liver cirrhosis, cancer, and those on breathing machines.

  Recruiting Universitatsmedizin Mainz - 1. Medizinische Klinik · Mainz, Rhineland-Palatinate · NCT06829290

• Comparing high-flow tracheal oxygen and T-piece for breathing trials

  This study is testing whether a new type of high-flow oxygen or a standard T-piece helps patients who are coming off mechanical ventilation breathe better during trials.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT06816706

• Impact of breathing methods on heart procedure success for atrial fibrillation

  This study tests whether using different breathing methods during a heart procedure for atrial fibrillation can help improve the success of the treatment.

  Recruiting Kocaeli City Hospital · Kocaeli · NCT06791915

• Ketamine Sedation in the ICU: A Comparison to Placebo in Mechanically Ventilated Adults

  This trial tests whether adding ketamine to standard sedation helps adults on a breathing tube in the ICU, compared with a placebo.

  Recruiting Phase 3 McMaster University · Hamilton, Ontario and 2 other locations · NCT06767358

• Impact of low phosphate levels on weaning off mechanical ventilation

  This study is testing if giving a phosphate supplement can help patients with low phosphate levels breathe better and get off mechanical ventilation more easily.

  Recruiting Peking Union Medical College · Beijing · NCT06754670

• Using electrical impedance tomography to guide PEEP settings in patients with moderate to severe ARDS

  This study is testing if using a special imaging technique to set breathing support can help patients with severe lung issues breathe better and recover faster while on a ventilator.

  Recruiting Vietnam Military Medical University · Hanoi · NCT06733168

• Using Remimazolam for Sedation in Patients After Heart Surgery

  This study tests if a new sedative called remimazolam can help heart surgery patients recover better and get off breathing machines faster compared to a standard sedative.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06716840

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Understanding factors related to weaning failure in critically ill patients on mechanical ventilation

  This study looks at why some critically ill patients on mechanical ventilation have trouble being taken off the ventilator, especially during their ICU stay.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires · NCT06683781

• Comparing early and late tracheostomy in patients with Guillain-Barre syndrome

  This study is testing if doing a tracheostomy sooner rather than later can help patients with Guillain-Barre syndrome who need breathing support recover faster and have better outcomes.

  Recruiting Meir Medical Center · Kfar Saba · NCT06612242

• Personalized diaphragm pacing to improve outcomes in ventilated patients

  This study is testing if a personalized diaphragm pacing treatment can help critically ill patients on ventilators recover better and get off the machines more easily.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06609577

• Smart lung support for adults on a ventilator in the ICU

  This observational project will test the IntelliLung AI decision support system in adults receiving invasive mechanical ventilation to see if its recommended ventilator settings match what clinicians actually choose.

  Recruiting at 3 sites Technische Universität Dresden · Dresden and 4 other locations · NCT06595602

• Observing physiological changes in ARDS patients in the prone position

  This study looks at how lying on the stomach affects breathing and oxygen levels in patients with Acute Respiratory Distress Syndrome to see if it can help improve their recovery.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06586736

• Calibration of esophageal balloon catheter for patients on mechanical ventilation

  This study is testing how to better calibrate a special balloon used in the esophagus to measure pressure in patients on mechanical ventilation, to see if it helps improve their care.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06584604

• Rehabilitation program for ICU patients on mechanical ventilation

  This study is testing a special rehabilitation program that includes nutrition and exercise for ICU patients on ventilators to see if it helps them recover better after their hospital stay.

  Recruiting at 52 sites Nantes University Hospital · Albi and 51 other locations · NCT06581939

• Predicting rehabilitation outcomes for ICU patients on mechanical ventilation

  This study is trying to see if early rehabilitation can help ICU patients on mechanical ventilation recover better and which patients are most likely to benefit from it.

  Recruiting Wuhan University · Wuhan, Hubei · NCT06532994

• Examining complications from mechanical ventilation in cardiac arrest survivors

  This study looks at the problems that can happen from using breathing machines in people who survive cardiac arrest to see how these issues affect their recovery.

  Recruiting Centre Hospitalier Sud Francilien · Corbeil-Essonnes · NCT06466980

• Evaluating the use of ProVent-14 score by ICU clinicians for predicting patient mortality

  This study tests if using the ProVent-14 score helps ICU doctors better predict the chances of survival for patients on mechanical ventilation for 14 days.

  Recruiting at 2 sites Rush University Medical Center · Chicago, Illinois and 2 other locations · NCT06452797

• Predicting extubation failure in ICU patients using a physiotherapy assessment

  This study is trying to see if a physiotherapy assessment can help predict which ICU patients on a ventilator might struggle after being taken off the machine.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06450678

• Personalized ventilation strategies for patients with acute respiratory distress syndrome

  This study is testing how different breathing support levels and body positions can help improve lung function in patients with severe acute respiratory distress syndrome.

  Recruiting Zhongda Hospital · Nanjing, Jiangsu · NCT06430554

• Understanding reverse trigger in patients on mechanical ventilation

  This study looks at how often patients with severe lung problems on mechanical ventilation experience a condition called reverse trigger, to see how it affects their treatment and recovery.

  Recruiting Hospital Civil de Guadalajara · Guadalajara · NCT06148467

• Exploring a new ventilation method for patients on mechanical ventilation during surgery

  This study is testing a new breathing method during surgery to see if it helps adults on mechanical ventilation clear carbon dioxide better than the standard method.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06024993

• Monitoring diaphragm function during breathing trials

  This study is testing a new way to monitor how well the diaphragm works in patients trying to breathe on their own without a ventilator.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06009731

• Pain management approach for trauma patients on mechanical ventilation

  This study tests whether a new pain management approach for trauma patients on breathing machines can help them feel more comfortable and reduce the time they need on the ventilator compared to the usual method.

  Recruiting MemorialCare Health System · Long Beach, California · NCT05751863

• Investigating neuromuscular blockers in mechanically ventilated patients

  This study is testing how different muscle relaxants affect patients on ventilators in emergency departments to see if they improve outcomes and reduce complications.

  Recruiting at 4 sites Washington University School of Medicine · Iowa City, Iowa and 3 other locations · NCT05534243

• Using inflatable air bags to improve lung function in ARDS patients in prone position

  This study tests if using inflatable air bags can help improve lung function in patients with Acute Respiratory Distress Syndrome (ARDS) who are lying on their stomachs.

  Recruiting Phase 2 Centre Hospitalier Universitaire, Amiens · Amiens · NCT05515484

• Personalized mechanical ventilation using ultrasound for patients with ARDS

  This study is testing if using lung ultrasound to personalize mechanical ventilation can help adults with severe ARDS live longer compared to standard care.

  Recruiting at 10 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Brussels and 10 other locations · NCT05492344

• Predicting who will need reintubation after a successful breathing trial

  This project will try to combine simple bedside signs to predict which mechanically ventilated adults who pass a spontaneous breathing trial are likely to need reintubation or die within a week.

  Recruiting Chongqing Medical University · Chongqing · NCT05069441

• Partial neuromuscular blockade to enable safe spontaneous breathing in acute hypoxemic respiratory failure

  This tests whether a low-dose infusion of the muscle-paralyzing drug cisatracurium can let people with moderate to severe low-oxygen respiratory failure on mechanical ventilation or venovenous ECMO breathe safely on their own while protecting their lungs.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04524585

• Assessing readiness for extubation in brain-injured patients

  This study is testing a new way to see if brain-injured patients are ready to be taken off a breathing machine to help them recover better and avoid complications.

  Recruiting at 14 sites University Hospital, Clermont-Ferrand · Angers and 20 other locations · NCT04080440

• Device to Control Pressure in Endotracheal Tube Balloons to Prevent Pneumonia

  This study is testing a new device that helps control the pressure in breathing tubes to see if it can lower the chances of patients getting pneumonia while on a ventilator.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT02514655

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Advancing Acute Respiratory Infection Care for Kids on Home Ventilators

  This grant aims to improve how doctors and families manage acute respiratory infections in children who rely on invasive long-term home ventilation.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11446490

• A Tablet-Based Emotion Regulation Program for Surrogate Decision-Makers of ICU Patients on Ventilation

  A randomized trial tests a brief tablet program to help people who decide for ICU patients on ventilation feel less anxious and make better decisions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11431767

• Optimizing pain relief for children on mechanical ventilation

  A large, multi-site trial tests whether adding non-opioid pain medicines to standard opioid care can reduce pain and lower opioid use in children on breathing machines in PICUs.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11408555

• Role of titin in diaphragm weakness during mechanical ventilation

  This grant studies how the diaphragm’s core proteins work together, especially titin and myosin, to understand why diaphragm weakness happens during mechanical ventilation.

  NIH research University of Arizona · Tucson, United States · NIH-11404951

• Time-limited trials to guide invasive ventilation decisions

  A scientific team is testing how short, structured trials of life-support in ICU patients with acute respiratory failure can help patients and families choose the best path.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11401902

• How breathing machines can harm the kidneys

  Doctors will look at how ventilators change kidney filtering and salt handling in people who are critically ill to help prevent kidney damage.

  NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11349714

• Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure

  Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11348199

• EPIPHANY: Using AI to guide when to do tracheostomy for patients on long ventilators

  An AI-based platform aims to help ICU teams decide the best time for tracheostomy in patients on prolonged mechanical ventilation, potentially reducing complications and costs.

  NIH research Bauhealth, INC. · Herndon, United States · NIH-11315591

• Remote monitoring for children who use home ventilators

  This project tries using wireless sensors and a clinician dashboard to track vital signs and symptoms for children on home breathing machines so care teams can make safer ventilator changes from afar.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11270836

• How titin affects diaphragm weakness during ventilator use

  This project looks at whether changes in the muscle protein titin make the breathing muscle (diaphragm) weaker in people on mechanical ventilators.

  NIH research University of Arizona · Tucson, United States · NIH-11192344

• Better pain relief for children on breathing machines

  Comparing whether adding acetaminophen or ketorolac to usual opioid care helps children on mechanical ventilation have less pain and need fewer opioids.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11184267

• Setting clearer time limits for ventilator (breathing machine) care

  This project will develop ways to help doctors and families decide how long to try ventilator (breathing machine) support for people with sudden severe breathing failure.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11107912

• Understanding how mechanical ventilation causes kidney injury

  This study is looking at how using a breathing machine for very sick patients might affect their kidneys and cause problems, with the goal of finding ways to protect kidney health in those who need this treatment.

  NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11084459

• Improving care for patients with acute respiratory failure at the end of life

  This study is looking at ways to improve care for patients with severe breathing problems, especially those who are close to the end of their lives, by trying out short-term treatment plans that help everyone involved—patients, families, and doctors—make better decisions together about what care is best for them.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11077805

• Investigating how mechanical ventilation affects children with severe lung injury

  This study is looking at how different ways of using breathing machines affect children with serious lung problems, hoping to find better ways to help them recover and avoid complications after their time in intensive care.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11064085

• Improving home care for children on mechanical ventilation using remote monitoring

  This study is all about helping kids who need special breathing machines at home by creating a system that lets parents easily share their child's health information with doctors, so they can provide better care, especially for Hispanic/Latinx families.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11031762

• Understanding how mechanical ventilation harms the lungs

  This study is looking at how the machines that help people breathe when they have serious lung problems can sometimes cause more harm, and it aims to find out how this happens so that we can make breathing treatments safer for patients with acute respiratory distress syndrome (ARDS).

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11014415

• Investigating how a protein affects lung function during mechanical ventilation

  This study is looking at how a protein changes when patients with acute respiratory distress syndrome (ARDS) are on mechanical ventilation, and how these changes might affect lung function, with the hope of finding better treatments to help ARDS patients breathe easier.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10998167

• Improving pain management for children on mechanical ventilation

  This study is looking at how to help manage pain better for kids on breathing machines by testing if adding non-opioid medicines like acetaminophen and ketorolac can help them feel more comfortable while using fewer stronger painkillers.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10990648

• Improving home ventilation for children with chronic lung disease

  This study is looking at ways to help kids with chronic lung disease who use home ventilation, by figuring out how long they need it and finding safe ways to reduce that time, all while listening to families and healthcare providers to make their care better and easier.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-10902008

• Understanding care patterns and outcomes for patients needing long-term mechanical ventilation

  This study is looking at how the type of care patients receive after surviving serious breathing problems and needing a ventilator for a long time affects their recovery and costs, so we can find better ways to help them in the future.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10867352

• Using music to help children on mechanical ventilation feel less pain and stress

  This study is looking at how listening to music can make kids on breathing machines feel less pain and stress, helping them recover better without needing as many medications.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10845283

• Understanding long-term outcomes for children on mechanical ventilation

  This study looks at how kids who needed long-term breathing support due to serious lung issues are doing over time, focusing on their recovery and quality of life after they leave the hospital.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10663936

Related topics

Quick answers

How many Mechanical Ventilation clinical trials are recruiting right now?

72, as of November 12, 2026. 6 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in China (16 trials), France (8 trials), United States (8 trials), Netherlands (7 trials), Canada (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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