Ventilator Hyperinflation Plus Body Positioning to Improve Gas Exchange in VAP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will randomly assign mechanically ventilated adults with confirmed VAP to receive ventilator hyperinflation combined with positioning in either supine or lateral decubitus. Arterial blood gases will be monitored over a six-day period to see how gas exchange changes with each positioning strategy. The trial aims to identify which position, when paired with hyperinflation, best enhances oxygenation and gas exchange in critically ill patients. Participants must have unilateral lung involvement and be hemodynamically stable to enroll.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mechanically ventilated patients ≥ 48 hours
* Diagnosed with VAP (clinical + chest X-ray)
* Age: 40-60 years
* Hemodynamically stable
* Unilateral lung involvement

Exclusion Criteria:

* Bilateral lung disease
* Unstable cardiovascular conditions
* Contraindications to positioning
* Re-intubation cases
* Presence of pneumothorax or air leak

Where it's running

• Mohamed Saied Zidan
  Cairo, Egypt Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting Extubation Problems With Machine Learning

  This study tests whether computer models can predict extubation failure in adults on ventilators in the ICU.

  Recruiting Universitas Indonesia · Jakarta, DKI Jakarta and 1 other locations · NCT07918924

• Levetiracetam Dosing in Critically Ill on CRRT

  This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07918833

• Respiratory Physiotherapy in Critically Ill Pneumonia Patients

  This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.

  Recruiting Hospital H+ Queretaro · Querétaro · NCT07909616

• Immersive VR for improving upper limb function in critically ill ICU patients

  This trial tests whether fully immersive virtual reality training added to standard ICU rehabilitation can help improve upper limb strength and coordination in adults with ICU-acquired weakness.

  Recruiting National and Kapodistrian University of Athens · Athens, Attica · NCT07901855

• Cycling with immersive VR for ICU patients recovering from critical illness

  In this crossover study, critically ill adults in the ICU will try three 10-minute cycling sessions to see if an immersive VR environment motivates them more than cycling with no visuals or cycling while watching a route on a TV.

  Recruiting KU Leuven · Leuven · NCT07894146

• Factors Influencing Outcomes in ECMO and Impella Patients

  This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT07885618

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.